Dental Caries and Salivary Interleukin - 6 among Preterm Postpartum Women in Relation to Baby Birth Weight : Comparative Study

Tajer, Dhamiaa M.; Al-Obaidi, Wesal A.

doi:10.12816/0015137

Cited by 4 publications

(8 citation statements)

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“…Moreover, when total protein level of saliva elevated, which leads to elevated saliva viscosity and reduced saliva quantities which in turn lead to decrease salivary cleansing action of saliva (54) . Other explanation for the increase in caries experience with increase SLE could be due to increase in salivary interlukin-6 (IL-6) among students with accumulative stress category, this result in line with other study (30) . Cytokines are important in immunity and inflammation (55) , however, it is known that proinflammatory cytokines play role in molecular mechanism connected to dental caries, but the details remain unexplained.…”

Section: Discussionsupporting

confidence: 89%

“…Indeed, both physical such as exercises and psychological stressors can provoke increases in proinflammatory cytokines (27) . Cytokines are closely associated with the pathogenesis of inflammation in oral soft tissues (28,29) , and evidence indicates that they contribute to the initiation and progression of dental caries (30) . Saliva contains free, biologically active cortisol as opposed to total cortisol present in serum or plasma and the concentration of cortisol in saliva is independent of the salivary flow rate (31,32) .…”

Section: Introductionmentioning

confidence: 99%

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Stressful Life Events in Relation to Dental Caries and Selected Salivary Constituents among Secondary School Students in Baghdad City

Abdul-Ameer¹,

Radhi²,

Abdul-Ghani³

2017

JBCD

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Background: stress is the reactions of the body to forces of a deleterious nature, infections and various abnormal states that tend to disturb its normal physiological equilibrium; It is described as adverse emotions or reactions to unpleasant experiences; Thus, any real or perceived physical, social, or psychological event or stimulus that causes bodies to react or respond have deleterious effects on the general and oral health. The aims of this study were to assess the severity of dental caries among the students with different categories of stressful life events in relation to physicochemical characteristics of whole stimulated saliva. Materials and Methods: the total sample is composed of 300 students (males only) aged 17-18 years old, who are randomly selected from 10 school in the First Al-Karkh/Baghdad. The total sample classified into three categories (less stress, more stress, accumulative stress) according to stressful life events scale (SLE); the sub sample consist of 60 students who are randomly selected from the total sample each category composed of 20 students. Diagnosis and recording of dental caries was assessed according to Decay, Missed, Filled surface index (D1-4MFS) of Muhlemann (1976). Stimulated salivary samples were collected from the 60 students then measuring salivary flow rate; and chemically analyzed to determine salivary interlukin-6 (IL-6), cortisol, and total protein. All data were analyzed using SPSS version 21. Results: Results recorded the highest mean rank value of (DMFS) was among the accumulative stress category of stressful life events scale followed by more stress category, the lowest mean rank value was among less stress category with statistically high significant difference (P< 0.001). For the severity of dental caries (DS) Fraction was higher among the accumulative stress category than more stress and less stress categories respectively (P< 0.001). According to the grades of lesion severity, for all fractions the higher mean rank values was among accumulative stress category with no statically differences except for (D2) was significant (P< 0.05). The data from salivary analysis showed that, the highest values of salivary total protein and (IL-6) were among the accumulative stress category, followed by more stress then the lowest value among less stress category, while the cortisol showed the opposite picture, however all these differences were not significant. DMFS correlated positively with flow rate among less stress and accumulative stress categories and negatively with more stress category, while for (DS) correlated negatively with flow rate with highly significant for more stress category and accumulative category and positively related with significant for low stress category. The salivary constituents showed negative correlation with (DMFS) for all categories of stressful life events scale except for IL-6 and cortisol were positively correlated for accumulative category with nonsignificant difference. Conclusion: The study revealed that, stressful life events hav...

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Stressful Life Events in Relation to Dental Caries and Selected Salivary Constituents among Secondary School Students in Baghdad City

Abdul-Ameer¹,

Radhi²,

Abdul-Ghani³

2017

JBCD

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“…Data analysis of the present study found that, in the control group, interleukin-6 (IL-6) was correlated positively with dental caries for both dentitions with no significant difference; this correlation was highly significant with D 3 and significant with d 4 . The same also reported by (11,12) . The explanation for this result was that the cells in the odontoblast layer initiate immunologic responses of the tooth to dental caries through proinflammatory cytokine and chemokine signaling, in the presence of bacteria, odontoblasts secrete various chemotactic cytokines for neutrophils, monocytes/macrophages, immature dendritic cells, and lymphocytes (33) , the migratory immune cells, in particular monocytes/ macrophages, release a large amount of pro-inflammatory cytokines such as IL-1β, TNF-α, IL-6, and IL-12, which regulate inflammatory reactions in the tissue (34) .…”

Section: Pedodontics Orthodontics and Preventive Dentistry 141supporting

confidence: 89%

“…Obesity is associated with elevated levels of IL-6 (8) and CRP (9,10) . As well as, dental caries associated with elevated levels of IL-6 (11,12) and CRP (13) .…”

Section: Introductionmentioning

confidence: 99%

The Salivary Inflammatory Biomarkers ( Interleukin-6 , C-Reactive Protein ) in Relation with Caries-Experience among a Group of 12 Year Old Obese Boys

Aziz¹,

Mohammed²

2016

JBCD

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Background: Obesity and dental caries are multifactorial diseases related to poor eating habits and show a close relationship with the sociodemographic characteristics of individuals presenting these diseases. This research aimed to investigate the severity of dental caries among group of obese boys aged 12 year in relation to salivary interleukin-6 (IL-6) and C-reactive protein (CRP) of unstimulated whole saliva in comparison with normal weighted boys of the same age. Materials and Methods: The study group included 40 obese boys, with an age of 12 year. The control group included 40 normal weighted boys of the same age. The total sample involved for nutritional status assessment using Body Mass Index specific for age and gender according to CDC growth chart (2000). The diagnosis and recording of dental caries conducted by using (D1-4MFS and d1-4mfs) index according to the criteria of Muhlemann (1976). The collection of unstimulated whole saliva was performed under standardized condition. Salivary samples were chemically analyzed for measuring IL-6 and CRP. Results: The caries experience among study group was lower than that among control group for both dentitions, with significant differences for D2, ds and dmfs and highly significant difference for d4. Salivary inflammatory biomarkers (IL-6, hs-CRP) were slightly higher among study group compared with control group with no significant difference between them. Salivary IL-6 and hs-CRP were negatively correlated with dental caries of both dentitions among study group with significant correlation between IL-6 and D2, while they were correlated positively with dental caries of both dentitions among control group with highly significant correlation between IL-6 and D3 and significant correlation between IL-6 and d4. Conclusion: Obesity and dental caries are associated with increased levels of salivary interleukine-6 and C-reactive protein, this making both obesity and dental caries as a state of inflammation that exacerbating immune responses in the body.

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“…The caries is a disease which is multifactorial, depending on many factors and is a complicated process. 3 Dental caries is also known as a microbial disease dynamic diet which involves a cyclic process of demineralization and remineralization. The caries early stage can be reversed by eliminating and modifying etiological factors such as diet, and plaque/biofilm and also by increasing in the protective factors such as salivary flow, and fluoride exposure.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Enamel Surface Microhardness with different Fluoride Varnishes–An In Vitro Study

Punathil¹,

Pulayath

Ismail

et al. 2018

The Journal of Contemporary Dental Practice

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Aim:This study aimed to assess the microhardness of the enamel surface after fluoride varnish application. Materials and methods:Thymol of 0.1% in distilled water was used to store the collected healthy sixty teeth. The samples were divided into three groups randomly as per the different application of fluoride varnish. Group A: Fluor protector varnish (FIV) application, group B: Duraphat varnish application and group C: Bifluorid 10 varnish application. The present study followed the pH cycling protocol. Microhardness tester was used to test the microhardness of enamel surface and was expressed as microhardness measurements of Vickers hardness number (VHN) which was performed at baseline, on the 3rd day andon 7th day.Results: At baseline, group A samples mean SMH value was 230.64 ± 12.32 which was slightly more than groupB with 229.45 ± 10.22 and group C with 230.10 ± 11.45. There was no significant difference showed with the analysis of variance between the groups. On the 3rd day, there was a slight increase in the mean SMH in group A with 235.39 ± 6.44 and no significant difference between the groups was seen statistically. On the 7th day, the group A showed high SMH value of 262.20 ± 4.89 compared to other groups which didn't show a significantly high statistical difference. Conclusion:On conclusion, post-application of fluorprotector varnish showed higher enamel surface microhardness compared to Duraphat and Bifluorid 10 varnishes. Clinical significance:In young children, fluoride varnishes are effectively used as a noninvasive, anti-caries agent in the treatment of initial caries. Therefore, in routine dental practice, the knowledge about different fluoride varnishes is of importance.

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Dental Caries and Salivary Interleukin - 6 among Preterm Postpartum Women in Relation to Baby Birth Weight : Comparative Study

Cited by 4 publications

References 0 publications

Stressful Life Events in Relation to Dental Caries and Selected Salivary Constituents among Secondary School Students in Baghdad City

Stressful Life Events in Relation to Dental Caries and Selected Salivary Constituents among Secondary School Students in Baghdad City

The Salivary Inflammatory Biomarkers ( Interleukin-6 , C-Reactive Protein ) in Relation with Caries-Experience among a Group of 12 Year Old Obese Boys

Assessment of Enamel Surface Microhardness with different Fluoride Varnishes–An In Vitro Study

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