Dental Caries: Strategies to control this preventable disease

Rugg-Gunn, A. J.

doi:10.5644/ama2006-124.80

Cited by 91 publications

(87 citation statements)

References 41 publications

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“…Oral diseases can be prevented by good oral hygiene, including the use of fluoride, combined with a lower frequency of dietary fermentable sugar consumption [5,6]. In addition, replacement of dietary fermentable sugars by artificial sweeteners, such as sugar alcohols, has been suggested to have a caries-preventive effect [7].…”

Section: Introductionmentioning

confidence: 99%

Effect of erythritol on microbial ecology of in vitro gingivitis biofilms

Janus

Volgenant

Brandt

et al. 2017

Journal of Oral Microbiology

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Gingivitis is one of the most common oral infections in humans. While sugar alcohols such as erythritol are suggested to have caries-preventive properties, it may also have beneficial effects in prevention of gingivitis by preventing maturation of oral biofilms. The aim of this study was to assess the effect of erythritol on the microbial ecology and the gingivitis phenotype of oral microcosms. Biofilms were inoculated with stimulated saliva from 20 healthy donors and grown in a gingivitis model in the continuous presence of 0 (control group), 5, and 10% erythritol. After 9 days of growth, biofilm formation, protease activity (gingivitis phenotype), and microbial profile analyses were performed. Biofilm growth was significantly reduced in the presence of erythritol, and this effect was dose dependent. Protease activity and the Shannon diversity index of the microbial profiles of the biofilms were significantly lower when erythritol was present. Microbial profile analysis revealed that presence of erythritol induced a compositional shift from periodontitis- and gingivitis-related taxa toward early colonizers. The results of this study suggest that erythritol suppresses maturation of the biofilms toward unhealthy composition. The gingivitis phenotype was suppressed and biofilm formation was reduced in the presence of erythritol. Therefore, it is concluded that erythritol may contribute to a healthy oral ecosystem in vitro.

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Section: Introductionmentioning

confidence: 99%

Effect of erythritol on microbial ecology of in vitro gingivitis biofilms

Janus

Volgenant

Brandt

et al. 2017

Journal of Oral Microbiology

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“…This epidemic of dental decay and its partial cure was discussed more fully in an earlier article in this issue of the Journal (1). In the UK, the first signs of improving dental health became evident in the late 1970s (2,3).…”

Section: Introductionmentioning

confidence: 99%

“…Although there are several ways of delivering fluoride (1), the number of people using each type of fluoride therapy differs considerably (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Fluoride toothpastes and fluoride mouthrinses

Rugg-Gunn

Bánóczy

2013

AMA

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“…However, dental caries still remains as one of the most prevalent diseases in young children, and continues to have significant medical, social, and economic consequences (1, 2). Dental caries, and especially severe early childhood caries (S-ECC), severely impacts the quality-of-life of affected children and their families, and has been found to directly correspond with several social-demographic variables, including lower education, sucrose-rich dietary habits, and poor oral hygiene (3).…”

mentioning

confidence: 99%

Children with severe early childhood caries: streptococci genetic strains within carious and white spot lesions

Gilbert

Joseph

et al. 2014

Journal of Oral Microbiology

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Background and objectivesMutans streptococci (MS) are one of the major microbiological determinants of dental caries. The objectives of this study are to identify distinct MS and non-MS streptococci strains that are located at carious sites and non-carious enamel surfaces in children with severe early childhood caries (S-ECC), and assess if cariogenic MS and non-cariogenic streptococci might independently exist as primary bacterial strains on distinct sites within the dentition of individual children.DesignDental plaque from children (N=20; aged 3–6) with S-ECC was collected from carious lesions (CLs), white spot lesions (WSLs) and non-carious enamel surfaces. Streptococcal isolates (N=10–20) from each site were subjected to polymerase chain reaction (PCR) to identify MS, and arbitrarily primed-PCR for assignment of genetic strains. Primary strains were identified as ≥50% of the total isolates surveyed at any site. In several cases, strains were characterized for acidurity using ATP-driven bioluminescence and subjected to PCR-determination of potential MS virulence products. Identification of non-MS was determined by 16S rRNA gene sequencing.ResultsSixty-four independent MS or non-MS streptococcal strains were identified. All children contained 1–6 strains. In many patients (N=11), single primary MS strains were identified throughout the dentition. In other patients (N=4), primary MS strains were identified within CLs that were distinct from primary strains found on enamel. Streptococcus gordonii strains were identified as primary strains on enamel or WSLs in four children, and in general were less aciduric than MS strains.ConclusionsMany children with S-ECC contained only a single primary MS strain that was present in both carious and non-carious sites. In some cases, MS and non-cariogenic S. gordonii strains were found to independently exist as dominant strains at different locations within the dentition of individual children, and the aciduric potential of these strains may influence susceptibility in the development of CLs.

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Dental Caries: Strategies to control this preventable disease

Cited by 91 publications

References 41 publications

Effect of erythritol on microbial ecology of in vitro gingivitis biofilms

Effect of erythritol on microbial ecology of in vitro gingivitis biofilms

Fluoride toothpastes and fluoride mouthrinses

Children with severe early childhood caries: streptococci genetic strains within carious and white spot lesions

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