Dental composite fillings and bisphenol A among children: a survey in South Korea

Chung, Sun-Young; Kwon, Ho-Jang; Choi, Youn‐Hee; Karmaus, Wilfried; Merchant, Anwar T.; Song, Keun‐Bae; Sakong, Joon; Ha, Mina; Hong, Yun–Chul; Kang, Dongmug

doi:10.1111/j.1875-595x.2011.00089.x

Cited by 21 publications

(11 citation statements)

References 24 publications

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“…The inverse association between BPA in a child's urine and the presence of white dental fillings, confirmed by the statistical model, is confusing, since BPA can be present as an impurity in the polymers used in fillings, which can then leach out as a result of hydrolysis through esterases present in saliva (Geens et al, 2012). Elevated BPA associated with presence of dental fillings has been shown by different in vitro, in vivo (Geens et al, 2012) and population-based studies in children (Chung et al, 2012). On the basis of in vivo studies, the highest exposures were measured immediately after sealant placement (Fleisch et al, 2010), and there is evidence that the released BPA depends on the producer of the dental resins/sealants (Fleisch et al, 2010;Joskow et al, 2006).…”

Section: Discussionmentioning

confidence: 94%

Urinary bisphenol A in children, mothers and fathers from Slovenia: Overall results and determinants of exposure

Tratnik

Kosjek

Heath

et al. 2019

Environmental Research

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In the present study, urinary bisphenol A (BPA) levels were reported for the first time in the Slovenian general population and were evaluated with regard to dietary and non-dietary exposure sources, and compared according to age, gender and area of residence. First morning urine was collected from children (6-11 years), their mothers (30-52 years) and fathers (30-53 years), living in urban and rural areas of Slovenia. Besides basic questionnaire data on general population characteristics, socio-economic status and dietary habits, BPA-specific data was also collected, including consumption of food and beverages from plastic and canned containers, presence of white dental fillings, the use of specific consumer products and hormonal treatments. Urine samples were analysed for both free and conjugated BPA using GC-MS/MS. The urinary levels of total BPA in children, mothers and fathers were low, with geometric means of 1.51, 0.79, and 0.20 μg/g creatinine, respectively. The levels were comparable with the levels reported for other European countries and were all below the current health-based guidance values. In line with large-scale surveys, the data revealed age-dependant BPA urinary levels, with the highest levels in the youngest age group. In mothers, urinary levels of BPA were determined by hormonal interactions more than dietary sources, while a positive association between urinary BPA and diet was apparent in children (canned food/drink and food from plastic material) and fathers (canned food/drink). The study clearly shows that physiological and behavioural differences account for differences in levels of urinary BPA among study groups, a finding that sets the priorities for future research.

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Section: Discussionmentioning

confidence: 94%

Urinary bisphenol A in children, mothers and fathers from Slovenia: Overall results and determinants of exposure

Tratnik

Kosjek

Heath

et al. 2019

Environmental Research

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“…In a study of 20 children, urinary BPA levels increased after dental composite treatment and had not returned to baseline levels at the end of follow-up two weeks later (Martin et al, 2005). A cross-sectional study in South Korean children found significantly higher urinary BPA levels (2.67 μg/g creatinine) in children with more than ten composites and sealants than those with no fillings (Chung et al, 2012). However, causality cannot be determined in these observational studies, particularly considering the numerous possible exposure routes of BPA in the environment.…”

Section: Introductionmentioning

confidence: 99%

Dental composite restorations and neuropsychological development in children: Treatment level analysis from a randomized clinical trial

et al. 2012

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Background Resin-based dental restorations may intra-orally release their components and bisphenol A. Gestational bisphenol A exposure has been associated with poorer executive functioning in children. Objectives To examine whether exposure to resin-based composite restorations is associated with neuropsychological development in children. Methods Secondary analysis of treatment level data from the New England Children’s Amalgam Trial, a 2-group randomized safety trial conducted from 1997–2006. Children (N=534) aged 6–10 y with >2 posterior tooth caries were randomized to treatment with amalgam or resin-based composites (bisphenol-A-diglycidyl-dimethacrylate-composite for permanent teeth; urethane dimethacrylate-based polyacid-modified compomer for primary teeth). Neuropsychological function at 4- and 5-year follow-up (N=444) was measured by a battery of tests of executive function, intelligence, memory, visual-spatial skills, verbal fluency, and problem-solving. Multivariable generalized linear regression models were used to examine the association between composite exposure levels and changes in neuropsychological test scores from baseline to follow-up. For comparison, data on children randomized to amalgam treatment were similarly analyzed. Results With greater exposure to either dental composite material, results were generally consistent in the direction of slightly poorer changes in tests of intelligence, achievement or memory, but there were no statistically significant associations. For the four primary measures of executive function, scores were slightly worse with greater total composite exposure, but statistically significant only for the test of Letter Fluency (10-surface-years β= −0.8, SE=0.4, P=0.035), and the subtest of color naming (β= −1.5, SE=0.5, P=0.004) in the Stroop Color-Word Interference Test. Multivariate analysis of variance confirmed that the negative associations between composite level and executive function were not statistically significant (MANOVA P=0.18). Results for greater amalgam exposure were mostly nonsignificant in the opposite direction of slightly improved scores over follow-up. Conclusions Dental composite restorations had statistically insignificant associations of small magnitude with impairments in neuropsychological test change scores over 4- or 5-years of follow-up in this trial.

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“…Depending on the number of RBSs and RBC restorations present in their oral cavity, the children were classified into four groups. The group of children with more than 11 sealants/restorations showed a BPA urine concentration level of 9.13 µg/g, which was much higher than the control group [60].…”

Section: Release From Resin Fissure Sealantsmentioning

confidence: 65%

“…Chung et al, obtained urine samples from 495 children aged between 8 to 9 years [60]. The medium creatinine-adjusted urinary BPA level was 2.08 ± 3.81 μg⁄g.…”

Section: Release Into Urinementioning

confidence: 99%

Bisphenol A – A Possible Health Issue Arising from Dental Restoratives. A Review

Aldossary¹

2018

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Dental resin-based materials are increasingly used in the contemporary dentistry. The elution of Bisphenol A from such materials is still gaining attention because of the potential biological effects on human. This review will discuss the possible health issue and the adverse effects on living organisms. Comprehensively, this review will discuss Bisphenol A elusion and release from different dental resin-based materials including composites, fissure sealants and orthodontic adhesives. Furthermore, the factors affecting the elution of Bisphenol A from dental materials will be explored, with an overview of its release into saliva and urine, and the methods of detection.

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Dental composite fillings and bisphenol A among children: a survey in South Korea

Abstract: Having many dental composite filling surfaces on teeth may increase the urinary BPA concentration in children.

Cited by 21 publications

References 24 publications

Urinary bisphenol A in children, mothers and fathers from Slovenia: Overall results and determinants of exposure

Urinary bisphenol A in children, mothers and fathers from Slovenia: Overall results and determinants of exposure

Dental composite restorations and neuropsychological development in children: Treatment level analysis from a randomized clinical trial

Bisphenol A – A Possible Health Issue Arising from Dental Restoratives. A Review

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