Dental-craniofacial manifestation and treatment of rare diseases

Luo, En; Liu, Hanghang; Zhao, Qiucheng; Shi, Bing; Chen, Qianming

doi:10.1038/s41368-018-0041-y

Cited by 30 publications

(28 citation statements)

References 298 publications

(267 reference statements)

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“…Given the diversity of the treated clinical pictures (ranging from infantile craniofacial anomalies to trauma or cancer), medical progress, and population ageing, a 10% annual increase of bone grafting procedures is expected [ 1 ]. To satisfy the growing need for bone repair, the development of new biomaterials and fabrication methods has received great attention.…”

Section: Introductionmentioning

confidence: 99%

Tough magnesium phosphate-based 3D-printed implants induce bone regeneration in an equine defect model

et al. 2020

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One of the important challenges in bone tissue engineering is the development of biodegradable bone substitutes with appropriate mechanical and biological properties for the treatment of larger defects and those with complex shapes. Recently, magnesium phosphate (MgP) doped with biologically active ions like strontium (Sr 2+ ) have shown to significantly enhance bone formation when compared with the standard calcium phosphate-based ceramics. However, such materials can hardly be shaped into large and complex geometries and more importantly lack the adequate mechanical properties for the treatment of load-bearing bone defects. In this study, we have fabricated bone implants through extrusion assisted three-dimensional (3D) printing of MgP ceramics modified with Sr 2+ ions (MgPSr) and a medical-grade polycaprolactone (PCL) polymer phase. MgPSr with 30 wt % PCL (MgPSr-PCL30) allowed the printability of relevant size structures (>780 mm 3 ) at room temperature with an interconnected macroporosity of approximately 40%. The printing resulted in implants with a compressive strength of 4.3 MPa, which were able to support up to 50 cycles of loading without plastic deformation. Notably, MgPSr-PCL30 scaffolds were able to promote in vitro bone formation in medium without the supplementation with osteo-inducing components. In addition, long-term in vivo performance of the 3D printed scaffolds was investigated in an equine tuber coxae model over 6 months. The micro-CT and histological analysis showed that implantation of MgPSr-PCL30 induced bone regeneration, while no bone formation was observed in the empty defects. Overall, the novel polymer-modified MgP ceramic material and extrusion-based 3D printing process presented here greatly improved the shape ability and load-bearing properties of MgP-based ceramics with simultaneous induction of new bone formation.

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Section: Introductionmentioning

confidence: 99%

Tough magnesium phosphate-based 3D-printed implants induce bone regeneration in an equine defect model

et al. 2020

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“…This is an advantage of deciduous teeth as a dental stem cell source over wisdom teeth, the most common source among adults; there are at most four sets in an individual. However, if craniofacial defects are associated with genetic disorders, the available number of deciduous teeth may be limited [51]. More importantly, premature decay or loss of deciduous teeth is often observed in uncontrolled oral pathogenic infections in children with severe systemic symptoms [52,53].…”

Section: Shedsmentioning

confidence: 99%

Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders

Masuda

Han

Kato

et al. 2021

IJMS

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A subpopulation of mesenchymal stem cells, developmentally derived from multipotent neural crest cells that form multiple facial tissues, resides within the dental pulp of human teeth. These stem cells show high proliferative capacity in vitro and are multipotent, including adipogenic, myogenic, osteogenic, chondrogenic, and neurogenic potential. Teeth containing viable cells are harvested via minimally invasive procedures, based on various clinical diagnoses, but then usually discarded as medical waste, indicating the relatively low ethical considerations to reuse these cells for medical applications. Previous studies have demonstrated that stem cells derived from healthy subjects are an excellent source for cell-based medicine, tissue regeneration, and bioengineering. Furthermore, stem cells donated by patients affected by genetic disorders can serve as in vitro models of disease-specific genetic variants, indicating additional applications of these stem cells with high plasticity. This review discusses the benefits, limitations, and perspectives of patient-derived dental pulp stem cells as alternatives that may complement other excellent, yet incomplete stem cell models, such as induced pluripotent stem cells, together with our recent data.

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“…While malformations and tumors of the skin in Proteus syndrome have been described more frequently, oral manifestations have been noted only rarely. For example, dental manifestations of Proteus syndrome are not mentioned in a detailed review on diagnosis of oral findings of syndromic rare diseases with craniofacial manifestations (48). Gingival hyperplasia was noted by Arendorf and Henslo (49).…”

Section: Genetics Prevalence Of Proteus Syndrome (Online Mendelianmentioning

confidence: 99%

Phenotype and Surgical Treatment in a Case of Proteus Syndrome With Craniofacial and Oral Findings

Friedrich

2021

In Vivo

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Background/Aim: Proteus syndrome is a sporadic disease that is particularly noticeable due to the disproportional growth of body segments. The disease is a genetic mosaic. The mutations can arise from any of the germ layers, an explanation of the very variable phenotype. The aim of this report is to communicate the diagnosis and management of an unusual case of Proteus Syndrome with special attention to oral and craniofacial findings. Case Report: A 15-year-old patient was referred for surgical treatment of pronounced skull malformations and correction of oral mucosal hyperplasia. Treatment caused significant improvement in facial appearance and oral soft tissue conditions. Conclusion: Surgical measures adapted to the local findings and symptoms can often relieve severe disfigurement of the patient.

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Dental-craniofacial manifestation and treatment of rare diseases

Cited by 30 publications

References 298 publications

Tough magnesium phosphate-based 3D-printed implants induce bone regeneration in an equine defect model

Tough magnesium phosphate-based 3D-printed implants induce bone regeneration in an equine defect model

Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders

Phenotype and Surgical Treatment in a Case of Proteus Syndrome With Craniofacial and Oral Findings

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