Dental delivery systems of antimicrobial drugs using chitosan, alginate, dextran, cellulose and other polysaccharides: A review

Paul, Mousumi; Pramanik, Siddhartha Das; Sahoo, Rudra Narayan; Dey, Yadu Nandan; Nayak, Amit Kumar

doi:10.1016/j.ijbiomac.2023.125808

Cited by 16 publications

(1 citation statement)

References 135 publications

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“…When formulated into hydrogels, HEC can release active agents slowly, creating a controlled release system that inhibits the growth and proliferation of microorganisms, such as bacteria and fungi. This property is particularly valuable in oral care, where the mouth harbors a diverse range of microorganisms that can lead to dental caries, periodontal diseases, and other oral infections [ 20 ]. HEC hydrogels can act as a protective barrier, preventing the attachment and colonization of harmful bacteria on teeth surfaces or oral tissues, thus maintaining oral health and preventing the progression of oral diseases.…”

Section: Introductionmentioning

confidence: 99%

Sustainable Treatment of Oral Traumatic Ulcers with Licorice Containing Hydrogels: Integrating Computational Modeling, Quality by Design, Green Synthesis, and Molecular Biological Evaluation

Moussa,

El Hoffy,

Mouselhy

et al. 2023

Pharmaceutics

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The urge to implement innovative approaches that align with eco-friendly practices and hold promise for enhancing oral health while promoting environmental sustainability has been increasing. This current work aims to develop a sustainable treatment for oral traumatic ulcers using licorice-based hydrogels (LHGs) containing hydroxyethyl cellulose (HEC) as the green gelling agent. Licorice root aqueous extract was phytochemically profiled using UPLC-ESI-MS/MS. Forty-three compounds were detected, with Glycyrrhizic acid being the major component of the extract (34.85 ± 2.77%). By implementing a Quality by Design (QbD) approach, the study investigates the effects of different licorice extract and HEC concentrations on key variables such as pH and viscosity of the prepared formulations, ulcer and wound healing scores, and tissue growth factors via a Full Factorial Experimental Design. The LHGs exhibited desirable consistency, spreadability, and clarity. Statistical analysis, employing an ANOVA test, revealed the high significance of the constructed models with the licorice concentration being the key independent factor affecting all dependent outputs. The pH as well as the viscosity of the prepared LHGs were positively influenced by licorice extract concentration, with higher concentrations leading to increased alkalinity and viscosity. Rheological behavior analysis revealed a pseudoplastic flow with demonstrated thixotropy which is advantageous for application and prolongation of residence time. The wound healing process was assessed through ulcer size, traumatic ulcer healing score (UHS), collagen-1 expression (COL-1), growth factors (EGF, VEGF), pro-inflammatory markers (TNF-α), wound healing score (WHS). LHGs prepared using higher levels of both factors, 30% dried licorice root extract and 4% HEC, demonstrated enhanced wound healing, elevated growth factor expression of 66.67% and 23.24%, respectively, and 88% reduced inflammation compared to the control group, indicating their potential in expediting oral ulcer recovery. Overall, these findings highlight the promising role of green licorice-based hydrogels in promoting sustainable oral mucosal healing.

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Section: Introductionmentioning

confidence: 99%

Sustainable Treatment of Oral Traumatic Ulcers with Licorice Containing Hydrogels: Integrating Computational Modeling, Quality by Design, Green Synthesis, and Molecular Biological Evaluation

Moussa,

El Hoffy,

Mouselhy

et al. 2023

Pharmaceutics

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Aloe vera hydrogel for supercooling applications: a review

Dada,

Popoola

2024

Discov Mater

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Aloe vera, a medicinal herb, is used in health care and cosmetics due to its biological activity. Its gel contains acemannan, which has high water content, biocompatibility, biodegradability, and customizable properties. Acemannan hydrogels can absorb and retain up to 99% of their weight, enabling supercooling and longer periods. There are literature reports on cellulose-based, chitosan-based, alginate-based, and starch-based hydrogels, but very limited studies on acemannan-based hydrogels, especially for supercooling applications. Hence, understanding AvP’s supercooling properties is crucial for developing reliable supercooling devices. The potential of hydrogels based on AvP for supercooling applications is examined in this review. The study reports on the idea of supercooling, how important it is in different fields, and how current techniques are limited. The review focuses on the characteristics, composition, and hydrogel formation process of AvP. It goes over AvP hydrogels’ capacity for supercooling, and the difficulties and potential paths for enhancing these hydrogels’ functionality and performance are also covered.

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Effect of UV-B irradiation and liquid smoke on physicochemical characterization of Salvia macrosiphon gum based edible films

Amininasab,

Hojjati,

Noshad

et al. 2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Dental delivery systems of antimicrobial drugs using chitosan, alginate, dextran, cellulose and other polysaccharides: A review

Cited by 16 publications

References 135 publications

Sustainable Treatment of Oral Traumatic Ulcers with Licorice Containing Hydrogels: Integrating Computational Modeling, Quality by Design, Green Synthesis, and Molecular Biological Evaluation

Sustainable Treatment of Oral Traumatic Ulcers with Licorice Containing Hydrogels: Integrating Computational Modeling, Quality by Design, Green Synthesis, and Molecular Biological Evaluation

Aloe vera hydrogel for supercooling applications: a review

Effect of UV-B irradiation and liquid smoke on physicochemical characterization of Salvia macrosiphon gum based edible films

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