1988
DOI: 10.1159/000261123
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Dental Effects of Lycasin® in the Diet of Laboratory Rats

Abstract: Lycasin® was included in diets fed to caries-active Osborne-Mendel rats for periods up to 8 weeks. The animals could tolerate up to 15–16% of Lycasin in dry-powder diets and up to 25% in pelleted diets before gastro-intestinal disturbance. Lycasin 80/55 at 25% in the diet was non-cariogenic, producing a very low level of caries, similar to that on a maize starch regimen and significantly below that on a sucrose regimen. At 16% in the diet D-sorbitol was even less cariogenic than Lycasin. Compared with the sucr… Show more

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Cited by 7 publications
(4 citation statements)
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References 15 publications
(19 reference statements)
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“…The use of sorbitol as the osmotic agent in OD is an alternative to replace the sucrose because of its low calories and relative sweetness of around 60% compared with sucrose (Silveira and Jonas ). Besides, the reductions in caries scored 89% with the sorbitol use in relation to sucrose (Grenby ). Sorbitol is naturally found in appreciable quantities in several fruits (e.g., berries, cherries, and apples), and it was one of the first polyols to become commercially available (Deis and Kearsley ).…”
Section: Introductionmentioning
confidence: 99%
“…The use of sorbitol as the osmotic agent in OD is an alternative to replace the sucrose because of its low calories and relative sweetness of around 60% compared with sucrose (Silveira and Jonas ). Besides, the reductions in caries scored 89% with the sorbitol use in relation to sucrose (Grenby ). Sorbitol is naturally found in appreciable quantities in several fruits (e.g., berries, cherries, and apples), and it was one of the first polyols to become commercially available (Deis and Kearsley ).…”
Section: Introductionmentioning
confidence: 99%
“…Attention has therefore turned to hydrogenated derivatives of the glucose syrups containing no free glucose, but said to retain suitable technological characteristics for confectionery manufacture. These include Lycasin®, produced from maize starch by Roquette Frères (Lille, France) [see Whitmore, 1985, andSicard andLeroy, 1983, for further details and properties].Aspects of the metabolism and cariogenicity of Ly casin in animals are covered in the two preceding pa pers, along with references to earlier work on Lycasin and various other hydrogenated glucose syrups 1 We are grateful to the Boots Co. for supplying the sweets.[ Grenby and Bull, 1988;Grenby, 1988; see also Havenaar, 1984]. Following the promising Findings on the low cariogenicity of Lycasin in comparison with su crose in animal experiments, the next stage was devel opment and manufacture of confectionery with Lyca sin instead of sucrose and laboratory testing of the new products.…”
mentioning
confidence: 99%
“…[Grenby and Bull, 1988;Grenby, 1988; see also Havenaar, 1984]. Following the promising Findings on the low cariogenicity of Lycasin in comparison with su crose in animal experiments, the next stage was devel opment and manufacture of confectionery with Lyca sin instead of sucrose and laboratory testing of the new products.…”
mentioning
confidence: 99%
“…The main advantages of polyols or polyol-con taining syrups are reported to be their lower caries-induc ing properties and reduced caloric content because of their slow and incomplete absorption from the intestine [Dills, 1989;Ziesenitz and Siebert, 1987]. Commercially available polyols are produced mainly by hydrogenation of acid hydrolysates of starch; Lycasin® 80/55 and Malbit® are examples of this category of product [Havenaar ct al" 1984;Izumitani et al, 1985;Grenby, 1988], These products contain significant quantities of maltitoi, a disaccharide polyol, in addition to other oligosaccharide polyols and sorbitol. However, crystalline maltitoi has become avail able only recently in quantities large enough to examine the effect on cariogenesis by mutans streptococci both in vitro and in vivo.…”
Section: Discussionmentioning
confidence: 99%