Dental extractions in hemophilic patients on aminocaproic acid prophylaxis

Epsilon-Aminocaproic Acid (EACA)

“…This may relate to the fact that the normal process of blood vessel retraction is probably impaired within the inflexible tooth socket and hence fibrin occlusion of the vessel may be particularly important. Initial trials by Reid [77], Cooksey [78], Tavenner [79], and Giordano [80] showed that EACA greatly decreased the amount of factor replacement therapy needed, episodes of postoperative bleeding, and length of hospital stay. In 1971, Walsh et al [76] reported a double-blind controlled trial using EACA (0.1 gm/kg IV prior to surgery, then 0.1 gm/kg orally every 6 hours for 10 days) or placebo in conjunction with a single preoperative dose of factor concentrate.…”