Dental Fluorosis and Periodontium: an Original Research Report of In Vitro and In Vivo Institutional Studies

Vandana, K L; Raj, B Srishti; Desai, Rupen

doi:10.1007/s12011-020-02494-0

Cited by 16 publications

(4 citation statements)

References 58 publications

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“…This shows that fluorosis can be reversed [ 61 ]. Similarly, skeletal fluorosis can be alleviated and reversed by eliminating fluoride intake, supplementing calcium, and supplementing a diet rich in antioxidants [ 62 , 63 ]. Targeted therapy for the above-mentioned genes can improve the prognosis of patients with fluorosis, which is a technology with broad application prospects.…”

Section: Discussionmentioning

confidence: 99%

In Silico Analysis of Ferroptosis-Related Genes and Its Implication in Drug Prediction against Fluorosis

Liu

et al. 2023

IJMS

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Fluorosis is a serious global public health problem. Interestingly, so far, there is no specific drug treatment for the treatment of fluorosis. In this paper, the potential mechanisms of 35 ferroptosis-related genes in U87 glial cells exposed to fluoride were explored by bioinformatics methods. Significantly, these genes are involved in oxidative stress, ferroptosis, and decanoate CoA ligase activity. Ten pivotal genes were found by the Maximal Clique Centrality (MCC) algorithm. Furthermore, according to the Connectivity Map (CMap) and the Comparative Toxicogenomics Database (CTD), 10 possible drugs for fluorosis were predicted and screened, and a drug target ferroptosis-related gene network was constructed. Molecular docking was used to study the interaction between small molecule compounds and target proteins. Molecular dynamics (MD) simulation results show that the structure of the Celestrol–HMOX1 composite is stable and the docking effect is the best. In general, Celastrol and LDN-193189 may target ferroptosis-related genes to alleviate the symptoms of fluorosis, which may be effective candidate drugs for the treatment of fluorosis.

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Section: Discussionmentioning

confidence: 99%

In Silico Analysis of Ferroptosis-Related Genes and Its Implication in Drug Prediction against Fluorosis

Liu

et al. 2023

IJMS

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“…В условиях чрезмерного и продолжительного поступления, в основном из питьевой воды, фторидов в организм ребёнка в период формирования зубов повышается вероятность развития флюороза [18]. Имеются работы, отмечающие разнонаправленное, но в большинстве случаев негативное влияние повышенных доз фторидов на ткани пародонта [19,20]. Исследования на людях и животных показа-Стоматология Dentistry ли отрицательное воздействие избыточных концентраций фторидов на клетки костей и процессы их ремоделирования, приводящие к хроническому флюорозу скелета, сопровождающемуся поражениями костей в виде остеосклероза или остеопороза, дегенеративными изменениями суставов, кальцификацией связок и пр.…”

Section: результаты исследованияunclassified

Prevalence of malocclusions under conditions of prolonged introduction of systemic fluorides in variable concentrations: Literature review

Belyaev

Гаврилова

Belyaev

et al. 2023

Acta biomedica scientifica

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The pathogenesis of malocclusions, which are common among the population of all countries, is well represented in the professional literature. The occurrence of malocclusions is associated with genetic and various environmental factors. Among the latter, fluorides which affect the prevalence of some dental diseases are of particular interest. However, there are few publications reflecting the frequency of malocclusion among the population in the regions with different levels of fluoride in drinking water. This problem seems to be significant in the context of the increasing impact of fluorine compounds on human health, including dental health.The aim of the study. To analyze the literature on the frequency of malocclusion among the population living in conditions of variable fluoride content in drinking water. A manual search of domestic and foreign literature was performed in the search databases PubMed, Medline and Google Scholar. From the initial list of publications, eighteen articles that met the inclusion criteria for the study were selected for analysis. We revealed significant variability of the research results. Some authors note a higher prevalence of malocclusions among the population under conditions of increased fluoride intake, others note a lower one, and still others did not reveal any differences between the values obtained in both samples. Most of the assessed publications did not methodologically meet modern international standards, and therefore were of little evidence.The literature data do not provide grounds for an unambiguous assessment of fluorine compounds as an environmental factor that indirectly affects the process of occlusion formation in humans and animals.The review did not allow to make a definitive conclusion on the possible impact of systemic fluorides on the prevalence and pattern of malocclusion in humans and animals. It requires the implementation of studies that comply with the principles of evidence-based medicine.

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“…Studies have shown that high fluoride environments have adverse effects on soft and hard body tissues ( 1 , 2 ). Periodontal tissue comprises hard tissues, such as alveolar bone and cementum, as well as soft tissues, including the gingiva and periodontal ligaments ( 3 ). The biological mechanism of orthodontic tooth movement includes the conversion of mechanical force signals into biological force signals, which stimulate various growth factors in periodontal tissue, thereby promoting alveolar bone remodeling and ultimately resulting in changes in tooth movement ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic fluorosis on the expression of VEGF/PI3K/AKT/eNOS in the gingival tissue of rats with orthodontic tooth movement

Ding,

Lai,

Jia

et al. 2024

Exp Ther Med

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It has been reported that the force of orthodontic correction triggers periodontal tissue remodeling by affecting angiogenesis. However, the manifestation of the vascular response to orthodontic tooth movement in the setting of chronic fluorosis is unclear. The aim of the present study was to preliminarily explore the effect of orthodontic treatment on the angiogenesis of gingival tissue in rats with chronic fluorosis by monitoring changes in the expression of vascular endothelial growth factor (VEGF), phosphatidylinositol-3 kinase (PI3K), AKT (or protein kinase B) and endothelial nitric oxide synthase (eNOS) in the gingival tissue. A total of 60 rats were randomly divided equally into the orthodontic group (O group; n=30) and fluorosis orthodontic group (FO group; n=30). Each of these groups was divided into 0-, 3-, 7-, 14- and 21-day groups (n=6/group). Fluorosis and orthodontic tooth movement models were established, and rats in each group were sacrificed for tissue sampling at the corresponding time points. Tissue morphology was observed via hematoxylin and eosin (H&E) staining. The protein and mRNA expression levels of VEGF, PI3K, AKT and eNOS in gingival tissue were detected by western blotting and reverse transcription-quantitative polymerase chain reaction, respectively. The H&E staining images showed that the FO group had smaller blood vessels and reduced vascular proliferation compared with the O group. Furthermore, the mRNA and protein expression levels of VEGF, PI3K, AKT and eNOS were reduced in the gingiva of rats in the FO group compared with the O group, and certain reductions were significant during the delayed tooth movement period. In addition, with the extension of the application of orthodontic stress, the mRNA and protein expression levels of VEGF, PI3K, AKT and eNOS in the gingiva of the O and FO groups showed a trend of increasing at first and subsequently decreasing, which corresponds with the tooth movement cycle. In conclusion, chronic fluorosis may inhibit the angiogenesis and the expression of the VEGF/PI3K/AKT/eNOS pathway in gingival tissue of orthodontic tooth movement.

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Dental Fluorosis and Periodontium: an Original Research Report of In Vitro and In Vivo Institutional Studies

Cited by 16 publications

References 58 publications

In Silico Analysis of Ferroptosis-Related Genes and Its Implication in Drug Prediction against Fluorosis

In Silico Analysis of Ferroptosis-Related Genes and Its Implication in Drug Prediction against Fluorosis

Prevalence of malocclusions under conditions of prolonged introduction of systemic fluorides in variable concentrations: Literature review

Effects of chronic fluorosis on the expression of VEGF/PI3K/AKT/eNOS in the gingival tissue of rats with orthodontic tooth movement

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