Dental fluorosis, fluoride in urine, and nutritional status in adolescent students living in the rural areas of Guanajuato, Mexico

Carmen, Aguilar-Díaz Fatima del; Javier, de la Fuente-Hernández; Aline, Cintra-Viveiro Cristina

doi:10.4103/2231-0762.195510

Cited by 21 publications

(16 citation statements)

References 17 publications

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“…The average level of fluoride in urine of boys was higher than in drinking water which may be an outcome of additional ingestion of fluoride via intake of tea, milk, vegetables, etc. Similar observations of higher F − in urine have been made in other studies too (Paez and Dapas 1983;Szymaczek and Lewicka 2005;Rango et al 2014;Del Carmen et al 2016) ascribing the reason to additional intake of bioavailable fluoride through food. Based on the survey for dental fluorosis, it was observed that majority of the subjects suffered from dental fluorosis with the degree of expression varying from nil to severe through mild and moderate as per Dean's Index.…”

Section: Resultssupporting

confidence: 75%

“…Some studies (García-Pérez et al 2013;Del Carmen et al 2016) have reported prevalence of dental fluorosis in school children of younger age groups of 8-12 years and 12-15 years as well. Therefore, monitoring of urinary fluoride concentration is a useful tool to assess the exposure particularly among the children at places with problem of endemic fluoride.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of fluoride in groundwater and urine, and prevalence of fluorosis among school children in Haryana, India

et al. 2018

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Considering the health effects of fluoride, the present study was undertaken to assess the concentration of fluoride in groundwater, and urine of school children in Bass region of Haryana state. Fluoride in groundwater was observed to vary from 0.5 to 2.4 mg/l with an average concentration of 0.46 mg/l. On the other hand, F − in urine ranged from below the detection limit to 1.8 mg/l among girls and 0.17-1.2 mg/l among the boys. Higher average concentration of fluoride in urine (0.65 mg/l for boys and 0.34 mg/l for girls) may be ascribed to exposure to bioavailable fluoride through food, milk, tea, toothpaste, etc., in addition to intake through groundwater. Relatively more intake of water and food by the boys might be the reason for more cases of severe dental fluorosis (44%) among boys compared to girls (29% cases of moderate to severe dental fluorosis). The groundwater quality for drinking was compromised with respect to dissolved solids, hardness, magnesium ions, and dissolved iron. Hydro-geochemical investigation revealed that rock-water interaction, in terms of direct cation exchange, dominantly regulates groundwater chemistry, and groundwater is of Ca-Na-HCO 3 type.

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Section: Resultssupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Assessment of fluoride in groundwater and urine, and prevalence of fluorosis among school children in Haryana, India

et al. 2018

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“…We used linear regression to evaluate the relationship between each of the biological measures of fluoride and concentrations of fluoride in community water. We controlled for the following potential confounders: maternal age [14,15] smoking status [16,17], BMI [18], gestational age at the time of sample collection, and race/ethnicity.…”

Section: Statistical Analysesmentioning

confidence: 99%

Maternal and fetal exposures to fluoride during mid-gestation among pregnant women in northern California

et al. 2020

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Background: Previous studies have shown a correlation between fluoride concentrations in urine and community water fluoride concentrations. However, there are no studies of the relationship between community water fluoridation, urine, serum, and amniotic fluid fluoride concentrations in pregnant women in the US. The aim of this study was to determine the relationship between maternal urine fluoride (MUF), maternal urine fluoride adjusted for specific gravity (MUF SG), maternal serum fluoride (MSF), amniotic fluid fluoride (AFF) concentrations during pregnancy, and community water fluoridation in Northern California. Methods: Archived samples of urine, serum and amniotic fluid collected from second trimester pregnant women in Northern California from 47 different communities in Northern California and one from Montana (n = 48), were analyzed for fluoride using an ion specific electrode following acid microdiffusion. Women's addresses were matched to publicly reported water fluoride concentrations. We examined whether fluoride concentrations in biospecimens differed by fluoridation status of the community water, and determined the association between water fluoride concentrations and biospecimen fluoride concentrations using linear regression models adjusted for maternal age, smoking, Body Mass Index (BMI), race/ethnicity, and gestational age at sample collection. Results: Fluoride concentrations in the community water supplies ranged from 0.02 to 1.00 mg/L. MUF, MSF , and AFF concentrations were significantly higher in pregnant women living in communities adhering to the U.S. recommended water fluoride concentration (0.7 mg/L), as compared with communities with less than 0.7 mg/L fluoride in drinking water. When adjusted for maternal age, smoking status, BMI, race/ethnicity, and gestational age at sample collection, a 0.1 mg/L increase in community water fluoride concentration was positively associated with higher concentrations of MUF (B = 0.

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“…According to our findings, the low UFE observed (Maguire et al, 2013) during monitoring of fluoridated milk programmes may therefore be related to the effect of moderate physical activity, that children undertake during their breaks, on F absorption and excretion. F concentrations in blood and urine have been shown not to be influenced by sex (Torra et al, 1998;Del Carmen et al, 2016) However, due to the possible different physiological responses following exercise in children compared to adults, as well as females compared to males, further work is required to determine the effects of exercise on F metabolism in young children and different sexes. These findings can help inform the evidence base for stakeholders and decision makers in dental public health as well as health professionals who may wish to review F dose and time of administration in different fluoridation programmes.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of fluoride in human adults: The effect of exercise

et al. 2021

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The literature is sparse in terms of the effect of exercise on the pharmacokinetics of fluoride (F) in humans. In a 4-treatment repeated measures cross-over study, we investigated F pharmacokinetics following no exercise (control) and three exercise intensity conditions (light, moderate and vigorous) in healthy adults. At a pre-experimental session, 8 participants (18-30y) residing in a non-fluoridatedarea, underwent a VO2 max test to guide the three exercise intensities for the experimental sessions.Participants were on a F-free regime one week before and throughout the four experimental weeks.We measured urinary F excretion (UFE), maximum plasma concentration (Cmax), lag time of Cmax (Tmax), and Area Under the Curve (AUC) for plasma F concentration against time, following F ingestion then no, light, moderate and vigorous exercise. Results showed no statistically significant difference in Tmax among all sessions; whereas Cmax for moderate exercise (226.2ng/ml) was significantly higher than for no (27.0ng/ml;p<0.001), light (105.6ng/ml;p=0.016) and vigorous (94.2ng/ml; p=0.008) exercise. Mean AUC over 0 to 90 min following F ingestion was also significantly higher in moderate exercise than for no (p<0.001), light (p=0.004) and vigorous (p=0.001) exercise. Mean UFE over 0-14h was 638.8, 718.7, 574.6 and 450.5µg for no, light, moderate and vigorous exercise, with no statistically significant differences among different sessions.In conclusion, this human experimental study suggests that moderate exercise may increase the fraction of F absorbed systemically which is therefore available to produce a biological effect. Future studies should be conducted with larger samples, different age groups and using different F doses.

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Dental fluorosis, fluoride in urine, and nutritional status in adolescent students living in the rural areas of Guanajuato, Mexico

Cited by 21 publications

References 17 publications

Assessment of fluoride in groundwater and urine, and prevalence of fluorosis among school children in Haryana, India

Assessment of fluoride in groundwater and urine, and prevalence of fluorosis among school children in Haryana, India

Maternal and fetal exposures to fluoride during mid-gestation among pregnant women in northern California

Pharmacokinetics of fluoride in human adults: The effect of exercise

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