The vascularized organs transplantation has become an effective method of treating patients with end-stage organ failure. However, prolonged immunosuppressive therapy causes many side effects, which are reflected in the state of the oral cavity. Infections in transplant recipients represent the most common postoperative complication. The development of infection is dependent on pathogenic microorganisms as bacteria, fungi and viruses, including CMV, EBV, HPV, HIV. To reduce the potential for serious problems in the oral cavity occurring after organ transplantation, each patient should be subjected to a thorough dental inspection and treated by physicians in specialized medical centers. The role of a dentist should involve the evaluation before and after transplantation according to specialized algorithm of dental treatment. The information concerning the presence of infection outbreaks and pathologic lesions in the oral cavity is an important signal for transplant physician to perform extended diagnostic testing, as well as to modify the immunosuppressive therapy.