Aim: The aim of this study was to assess the level, sources of information, awareness, and acceptance of dental implant therapy among dental patients in Aseer region, Kingdom of Saudi Arabia. Materials and methods: Information on demographic variables, level and sources of information, awareness, and acceptance of dental implant therapy as a treatment modality was obtained by self-explanatory survey containing 17 questions. The data were collected at five government dental health centers at Aseer region. The survey forms were distributed by in-charge dentist to the patients who were on routine visit. A total of 500 questionnaires were distributed out of which 479 were included in the survey. Results: The survey analysis demonstrated that 87% of participants were aware of dental implant therapy. Participants with high education level showed more awareness compared with lower education level (p < 0.05); 22.2% of participants were well informed about dental implants, 59.3% of them were moderately informed, 16.1% of them were poorly informed, and 2.4% were not informed about dental implants. The high cost (41.5%) was the major reason for people not choosing implant therapy followed by other reasons, such as fear of unknown side effects (33.0%), the need for surgery (13.5%), and long duration of treatment (12.0%). Conclusion: The surveyed participants in Aseer region were well aware about dental implants as a treatment option in replacing missing teeth. However, the dentists should provide accurate information to the patients regarding implant therapy irrespective of the patient's willingness to undergo therapy or not. High treatment cost for dental implant therapy was the main reason for patients refraining from implant therapy.