Dental Implant Placement in Patients With Osteoporosis

Barbu, Horia Mihail; Comăneanu, Raluca Monica; Andreescu, Claudia Florina; Mijiritsky, Eitan; Nita, Tiberiu; Lorean, Adi

doi:10.1097/scs.0000000000001958

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…Subjects with osteoporosis show a decreased number and thickness of trabecular plates as a characteristic feature of the disease. There have also been anecdotal reports that the incidence of maxillofacial fractures during the placement of endosseous implants is increased in patients with osteoporosis [32]. Additionally, bone changes evident on panoramic radiographs can be correlated with general osteoporosis, and dental radiography can serve as both a reliable indicator of bone loss in osteoporosis and a useful tool for diagnosing skeletal osteoporosis [33].…”

Section: Dental Implants and Osteoporosismentioning

confidence: 99%

Osseointegration of Dental Implants and Osteoporosis

Gibreel¹,

Mohamed²,

Suraj³

et al. 2022

Dentistry

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Osteoporosis is a disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and susceptibility to fractures. Osteoporosis also results in loss of bone mineral density throughout the body, including the maxilla and mandible. Successful osseointegration of dental implants is attributed to their ability to integrate well with bone. The influence of bone quality on dental implant osseointegration has been discussed in several studies, and higher rates of dental implant failure have been reported in patients with low bone quality and an inadequate bone volume. Osteoporosis represents a risk factor for osseointegration, and this relationship may be derived from the association of the disease with a deficiency in bone formation. This condition would compromise the healing capacity and the apposition of bone at the implant interface. Currently, there is no clear consensus regarding dental implant treatment in osteoporotic individuals. Studies have revealed contradictory reports regarding the success and failure of dental implants in patients with osteoporosis. Antiresorptive agents have been widely used to treat osteoporosis. Dental implant placement in patients on bisphosphonate therapy may trigger osteonecrosis of the bone. Hence, it is important to analyze factors that have to be taken into consideration prior to implant therapy in patients with osteoporosis and those undergoing treatment. This chapter outlines dental implant osseointegration under osteoporotic conditions. The possible effect of bisphosphonate therapy on dental implant survival will also be discussed based on the current literature.

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Section: Dental Implants and Osteoporosismentioning

confidence: 99%

Osseointegration of Dental Implants and Osteoporosis

Gibreel¹,

Mohamed²,

Suraj³

et al. 2022

Dentistry

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“…Osteoporosis is a relative contraindication of oral implant [ 1 , 2 ]. Jawbone loss, one of the common accompanied phenotypes of osteoporosis, brings risk to poor osseointegration [ 3 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Jawbone loss, one of the common accompanied phenotypes of osteoporosis, brings risk to poor osseointegration [ 3 – 6 ]. Jawbone mass is essential for early stability and long-term survival of dental implants [ 1 , 2 ]. Therefore, concentration on jawbone health of osteoporotic individuals seems to be imperative.…”

Section: Introductionmentioning

confidence: 99%

OSGIN2 regulates osteogenesis of jawbone BMSCs in osteoporotic rats

Liu

Liang

et al. 2022

BMC Mol and Cell Biol

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Background Augmentation of oxidative stress after estrogen deficiency leading to functional deficiency of jawbone bone marrow mesenchymal stem cells (BMSCs) causes jawbone loss in osteoporosis. OSGIN2, an oxidative stress induced factor, has been found to be associated with skeletal diseases. This study aims to investigate the function of OSGIN2 in jawbone BMSCs of osteoporotic rats. Jawbone BMSCs were used. Results Oxidative stress was increased in jawbone BMSCs of osteoporotic rats, meanwhile OSGIN2 was also up-regulated. Osteogenesis of jawbone BMSCs was declined under oxidative stress, while silence of OSGIN2 ameliorated the osteogenic deficiency. RORα and its downstream osteogenic markers (BSP and OCN) decreased under oxidative stress, while knocking-down of OSGIN2 restored their expressions. Inhibition of OSGIN2 improved the osteogenesis of jawbone BMSCs under oxidative stress, whereas down-regulation of RORα offset the effect. Intra-jawbone infusion of si-OSGIN2 rescued jawbone loss and promoted new bone deposition of osteoporotic rats. Conclusions Oxidative stress is redundant in osteoporosis, which results in up-regulation of OSGIN2. OSGIN2 restricts osteogenic ability of jawbone BMSCs via regulating RORα, while silencing of OSGIN2 rescues the osteogenic deficiency of osteoporotic rats.

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“…Osteoporosis caused by bone mass loss leads to local fractures in the hip, vertebral body, and distal forearm. At present, it is difficult to heal bones directly by external fixation because the bone damage was caused by local osteoporosis, which often leads to failure of external fixation of instruments, as well as weak bonding of bone at the interface between the screw and bone tissue [22][23][24] . Therefore, developing an injectable material for bone regeneration has become an urgent issue for improving bone reconstruction and repair of the local damaged bone cavity (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

Adhesive liposomes loaded onto an injectable, self-healing and antibacterial hydrogel for promoting bone reconstruction

et al. 2019

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Loading hydrogels with bioactive agents is an important method for expanding the functional application of hydrogels. However, how to improve the local administration and slow release of drugs from a hydrogel is a challenge when using hydrogels loaded with drugs. In this paper, we first developed adhesive liposomes (A-LIP) loaded with BMP-2. Then, we incorporated the A-LIP into PEG hydrogels based on the coordinated cross-linking principle of SH-PEG and Ag + , fabricating an injectable, antibacterial and self-healing multifunctional drug delivery system. The adhesive lipo-hydrogel (A-LIP-PEG) fabricated by mixing PEG hydrogels and adhesive liposomes can be locally injected into an osteoporotic fracture and bone marrow cavity, where A-LIP-PEG can release adhesive liposomes that adhere to the bone injury area and promote bone reconstruction. Based on the principle of electrostatic attraction, tissue nonspecific A-LIP were fabricated by grafting octadecylamine onto liposomes. Because of the coordination and crosslinking of thiolated polyethylene (SH-PEG) and Ag + , the A-LIP-PEG showed excellent injectability and self-healing properties; further, because of the presence of Ag + , the A-LIP-PEG showed effective inhibition of S. aureus and Escherichia coli. The liposomes released by the A-LIP-PEG were able to adhere to tissue. In vitro studies showed that A-LIP-PEG significantly promoted osteogenic differentiation and had no significant effect on cell proliferation. Compared with common lipo-hydrogel (LIP-PEG), the A-LIP-PEG had better tissue adhesion in vivo, which led to better osteogenic differentiation and faster local bone remodeling of osteoporotic fractures in rats. This research developed a novel hydrogel system with adhesive liposomes to expand the application of hydrogels.

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Dental Implant Placement in Patients With Osteoporosis

Cited by 7 publications

References 6 publications

Osseointegration of Dental Implants and Osteoporosis

Osseointegration of Dental Implants and Osteoporosis

OSGIN2 regulates osteogenesis of jawbone BMSCs in osteoporotic rats

Adhesive liposomes loaded onto an injectable, self-healing and antibacterial hydrogel for promoting bone reconstruction

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