Dental implant surgery for patients on oral anticoagulants

Zoman, Hamad Al

doi:10.1186/isrctn36419844

Cited by 1 publication

(2 citation statements)

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“…Even if it appears stable under mild conditions, in our experiment degradation was achieved in alkaline solution under more severe conditions, using high molarity alkaline solution and reflux. Similar results were reported in earlier studies where degradation under alkaline conditions was performed using reflux [17] or prolonged time of treatment with higher alkaline concentration [18][19][20]. Also, in our study donepezil hydrochloride showed lower degree of degradation under applied conditions for thermal stress, but it is reported that under prolonged exposure to high temperature considerable degradation was induced [19].…”

Section: Resultssupporting

confidence: 91%

“…Based on the investigation of forced degradation behavior in our work, donepezil was found to be stable under mild acidic condition and alkaline condition, but sensitive to degradation with hydrogen per- oxide, which is also reported in earlier studies on stability of donepezil hydrochloride [17][18][19][20][21]. Even if it appears stable under mild conditions, in our experiment degradation was achieved in alkaline solution under more severe conditions, using high molarity alkaline solution and reflux.…”

Section: Resultssupporting

confidence: 82%

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Liquid chromatography and liquid chromatography-mass spectrometry analysis of donepezil degradation products

Mladenović¹,

Jadranin

Pavlović³

et al. 2015

CI&CEQ

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This study describes the investigation of degradation products of donepezil (DP) using stability indicating RP-HPLC method for determination of donepezil, which is a centrally acting reversible acetylcholinesterase inhibitor. In order to investigate the stability of drug and formed degradation products, a forced degradation study of drug sample and finished product under different forced degradation conditions has been conducted. Donepezil hydrochloride and donepezil tablets were subjected to stress degradation conditions recommended by International Conference on Harmonization (ICH). Donepezil hydrochloride solutions were subjected to acid and alkali hydrolysis, chemical oxidation and thermal degradation. Significant degradation was observed under alkali hydrolysis and oxidative degradation conditions. Additional degradation products were observed under the conditions of oxidative degradation. The degradation products observed during forced degradation studies were monitored using the high performance liquid chromatography (HPLC) method developed. The parent method was modified in order to obtain LC-MS compatible method which was used to identify the degradation products from forced degradation samples using high resolution mass spectrometry. The mass spectrum provided the precise mass from which derived molecular formula of drug substance and degradation products formed and proved the specificity of the method unambiguously. [Projekat Ministarstva nauke Republike Srbije, br. 172013]

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Section: Resultssupporting

confidence: 91%