PurposeThe study aimed to compare the performance of four pre‐trained convolutional neural networks in recognizing seven distinct prosthodontic scenarios involving the maxilla, as a preliminary step in developing an artificial intelligence (AI)‐powered prosthesis design system.Materials and methodsSeven distinct classes, including cleft palate, dentulous maxillectomy, edentulous maxillectomy, reconstructed maxillectomy, completely dentulous, partially edentulous, and completely edentulous, were considered for recognition. Utilizing transfer learning and fine‐tuned hyperparameters, four AI models (VGG16, Inception‐ResNet‐V2, DenseNet‐201, and Xception) were employed. The dataset, consisting of 3541 preprocessed intraoral occlusal images, was divided into training, validation, and test sets. Model performance metrics encompassed accuracy, precision, recall, F1 score, area under the receiver operating characteristic curve (AUC), and confusion matrix.ResultsVGG16, Inception‐ResNet‐V2, DenseNet‐201, and Xception demonstrated comparable performance, with maximum test accuracies of 0.92, 0.90, 0.94, and 0.95, respectively. Xception and DenseNet‐201 slightly outperformed the other models, particularly compared with InceptionResNet‐V2. Precision, recall, and F1 scores exceeded 90% for most classes in Xception and DenseNet‐201 and the average AUC values for all models ranged between 0.98 and 1.00.ConclusionsWhile DenseNet‐201 and Xception demonstrated superior performance, all models consistently achieved diagnostic accuracy exceeding 90%, highlighting their potential in dental image analysis. This AI application could help work assignments based on difficulty levels and enable the development of an automated diagnosis system at patient admission. It also facilitates prosthesis designing by integrating necessary prosthesis morphology, oral function, and treatment difficulty. Furthermore, it tackles dataset size challenges in model optimization, providing valuable insights for future research.