Dental Infection and Resistance—Global Health Consequences

Haque, Mainul; Sartelli, Massimo; Haque, Seraj Zohurul

doi:10.3390/dj7010022

Cited by 77 publications

(67 citation statements)

References 182 publications

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“…Fusobacterium nucleatum , a critical component of periodontal plaque, also plays a role in periodontal disease (Signat et al ), whereas oral A. actinomycetemcomitans infection is often associated with aggressive periodontitis and halitosis (Amou et al ). Nowadays, various antibiotics, mouthwashes and dental gels are used to treat these oral diseases (Arteagoitia et al ; Haque et al ), however, multiple antibiotic‐resistant oral pathogens can arise due to the abuse of these drugs. Therefore, using probiotics to control the growth of oral pathogens and maintain the stability of the oral microbiota is a promising option for preventing antibiotic resistance when treating oral diseases (Mahasneh and Mahasneh ).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of viable and heat‐killed probiotic strains against oral pathogens

Chen

Hsieh

et al. 2020

Lett Appl Microbiol

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Probiotics can stabilize gut flora, regulate intestinal immunity and protect the host from enteric diseases; however, their roles in oral health have received little attention compared to their roles in gut health. Nowadays, the prevalence of sugar‐sweetened foods and abuse of antibiotics contribute towards dysbiosis of oral microbiota and drug resistance development in oral pathogens, resulting in various intractable oral diseases. We screened the antibacterial activities of viable and heat‐killed probiotic strains against the oral pathogens Streptococcus mutans, Porphyromonas gingivalis, Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans. The probiotic strains Lactobacillus salivarius subsp. salicinius AP‐32, L. rhamnosus CT‐53, L. paracasei ET‐66 and Bifidobacterium animalis subsp. lactis CP‐9 displayed strong antipathogenic activities, whereas heat‐killed AP‐32, CT‐53 and ET‐66 displayed high levels of pathogen inhibition. The antibacterial activities of these probiotics were not associated with their H2O2 production; L. acidophilus TYCA02 produced high levels of H2O2 but merely exhibited moderate antibacterial activities. Oral tablets containing probiotics showed positive inhibitory effects against oral pathogens, particularly those containing viable probiotics. Our results indicate that probiotics prevent the growth of oral pathogens and improve oral health, providing insights into the antipathogenic efficacy of different probiotic species and their potential role in functional foods that improve oral health. Significance and Impact of the Study Our study provides insights into the antipathogenic efficacy of different probiotic species and their potential roles in developing functional foods to improve oral health. We showed that the probiotic strains Lactobacillus salivarius subsp. salicinius AP‐32, L. rhamnosus CT‐53, L. paracasei ET‐66 and Bifidobacterium animalis subsp. lactis CP‐9 have great potential for use in the development of functional foods to improve oral health. Since active probiotics may provide strong and long‐term protection, the development of functional food products should favour the use of viable bacteria.

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Section: Introductionmentioning

confidence: 99%

Antibacterial activity of viable and heat‐killed probiotic strains against oral pathogens

Chen

Hsieh

et al. 2020

Lett Appl Microbiol

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“…the method of keeping oral cavity free from pathological conditions that affect mouth like gum diseases, cavities, mouth sores and ulcers. [2] Good oral hygiene is essential for the well-being of an individual. However lack of knowledge, negative attitude and poor oral hygiene practices may predispose to oral related diseases.…”

mentioning

confidence: 99%

“…However lack of knowledge, negative attitude and poor oral hygiene practices may predispose to oral related diseases. [2,3]. As oral health affect overall health of a child, it is therefore of paramount importance to maintain oral hygiene of school going children.…”

mentioning

confidence: 99%

Knowledge, Attitude and Practices towards Oral Hygiene among Students of Medhanealem High School, Addis Ababa, Ethiopia

Abate¹,

Ephrem²,

Gebremariam³

et al. 2020

Preprint

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Background : poor oral health can affect a person’s day today as well as overall quality of life. Discomforts from experience of pain, problems with eating and chewing, embarrassment about the shape, missing, discolored or damaged teeth can adversely affect peoples’ daily lives and well-being. The aim of this study was to assess the knowledge, attitude and practice of oral hygiene among preparatory students of Medhanealem high School in Addis Ababa, Ethiopia. Method : A cross sectional study design was conducted using a self-administered questionnaire from June to September 2019 in Medhanealem high school, Addis Ababa. Data was analyzed using SPSS V.20 and a descriptive statistics was employed to present results on knowledge, attitude and practices of high school students towards oral hygiene. Result : A total of 320 students have participated in the study, of whom 207(64.7 % ) were female. The study revealed that 201(62.8 % ) of the respondents had poor knowledge with regard to oral hygiene, about half (52.1 % ) of the students had negative attitude toward oral hygiene, and their oral hygiene practices were still low that 193 (60.4 % ) of the students reported inadequate practice. The chewed stick (mefakiya) is the most common oral hygiene aid used for cleaning teeth which was adopted by 134(51 % ) students. Conclusions : The study showed that oral hygiene knowledge, attitude and practice among the secondary school students in Medanealem preparatory school were not satisfactory. The findings of this study suggest that awareness on the importance of oral hygiene needs to be enhanced along with regular education.

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“…AMX is a moderate‐spectrum, semisynthetic ß‐lactam antibiotic that is active against a wide range of Gram‐positive bacteria, but it has a limited range against of Gram‐negative organisms. Beta‐lactams act by binding to penicillin‐binding proteins that inhibit a process called transpeptidation, thus leading to the activation of autolytic enzymes in the bacterial cell wall …”

Section: Antibiotic Prophylaxis Guidelines Recommended By Aha For Bacmentioning

confidence: 99%

“…Beta-lactams act by binding to penicillin-binding proteins that inhibit a process called transpeptidation, thus leading to the activation of autolytic enzymes in the bacterial cell wall. 37,38 The susceptibility of AMX is affected by bacterial resistance, which is becoming a central issue in the biomedical field. ß-lactamase production is one of the most common mechanisms of ABR; these enzymes, which cleave the ß-lactam ring, are produced by Gram-positive and Gramnegative bacteria.…”

Section: Amoxicillin (Amx)mentioning

confidence: 99%

Prevention of infective endocarditis and bacterial resistance to antibiotics: A brief review

Loyola-Rodríguez

Miranda

Loyola-Leyva

et al. 2019

Special Care in Dentistry

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The purpose of this statement is to debate the recommendations of the American Heart Association (AHA) for the prevention of infective endocarditis through an antibiotic prophylaxis protocol and its relation with bacterial resistance to antibiotics. Since dental infections involve biofilms that include several bacterial species (Gram‐negative and Gram‐positive), it is essential, from the dental point of view, to consider the frequency, magnitude, and duration of bacteremia associated with active dental infections before applying antibiotic prophylaxis. The actual guidelines for antibiotic prophylaxis should be revised according to recent evidence of bacterial resistance. Amoxicillin/clavulanic acid and moxifloxacin should be considered due to their effectiveness against bacteria associated with oral, GU, and GI infections and the low rates of antibiotic resistance associated with these antibiotics, instead of the actual protocol, which includes amoxicillin (2 g) or clindamycin (600 mg) administered an hour before the dental procedures. The breaking point to test the antibiotic bacterial resistance (ABR) had a wide range in the different studies that were analyzed, which could explain the widely varied ABR percentages reported for the various antibiotics used for antibiotic prophylaxis.

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Dental Infection and Resistance—Global Health Consequences

Cited by 77 publications

References 182 publications

Antibacterial activity of viable and heat‐killed probiotic strains against oral pathogens

Antibacterial activity of viable and heat‐killed probiotic strains against oral pathogens

Knowledge, Attitude and Practices towards Oral Hygiene among Students of Medhanealem High School, Addis Ababa, Ethiopia

Prevention of infective endocarditis and bacterial resistance to antibiotics: A brief review

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