“…Epinephrine definitely has b 1 effects that result in increased heart rate; however, it also is important with respect to pain control, and lack of pain control tends to result in increased endogenous production of norepinephrine, which is more problematic with respect to both heart rate and blood pressure. 28,[45][46][47][48] In 2006, Karp and Moss 43 defended their recommendations regarding epinephrine risks with respect to LQTS by stating, "Epinephrine-containing local anesthetics have never been shown to be safe and effective for patients with LQTS." However, in 2007, Wynn 49 reported that articaine 4% with 1:200,000 epinephrine was deemed safe and effective in dental patients with LQTS.…”