Dental management strategies for Molar Incisor Hypomineralization

Olmo-González, Belisa; Moreno-Lopez, Rosa; Ribera-Uribe, Manuel

doi:10.1016/j.pdj.2020.09.002

Cited by 7 publications

(5 citation statements)

References 107 publications

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“…In particular, the use of remineralizing agents has been found to increase the mineral density of hypomineralized enamel in MIH affected teeth. [17][18][19][20] A commonly used remineralizing agent is uoride due to the overwhelming evidences supporting its effectiveness in inhibiting tooth demineralization and promoting remineralization of initial caries. 52 However, both dental and systematic risks, such as uorosis and toxicity, have been associated with increased uoride exposure, particularly in children.…”

Section: Discussionmentioning

confidence: 99%

“…This is in line with previous studies that demonstrated the effectiveness of uoride in remineralizing different types of hypomineralized enamel. 3,14,[17][18][19][20]52,59,60 In particular, some authors have investigated the bene t of a regular application of uoride on the remineralization of MIH lesions. 18,20,61 Restrepo et al 61 , for example, reported no signi ant increase in the MD of MIH lesions, measured by quantitative laser uorescence (QLF), after the application of uoride varnish.…”

Section: Discussionmentioning

confidence: 99%

“…Several techniques pertaining to remineralization of MIH lesions have been described in the literature including, the application of toothpastes and varnishes containing uoride (with or without tricalcium phosphate), casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) or casein phosphopeptide-amorphous calcium uoride phosphate (CPP-ACFP). [17][18][19][20] Toothpastes based on hydroxyapatite (HAP) were shown to have comparable effects to uoride toothpastes in remineralization of initial caries lesions [21][22][23][24][25][26] and prevention of dental decay while excluding the risk of uorosis 27 and other uoride-associated side effects. 28,29 The synthesized particles of HAP are structurally similar to the crystallites found in human enamel 30 , have analogous properties, and can readily penetrate enamel surface.…”

Section: Introductionmentioning

confidence: 99%

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Remineralization of Molar Incisor Hypomineralization (MIH) with a Hydroxyapatite Toothpaste: an in-situ study

Farah

Liu

Phillips

et al. 2022

Preprint

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Aim: This randomized, double-blind, crossover, in-situstudy, compared the efficacy of toothpastes based on hydroxyapatite (HAP; fluoride-free) or fluoride, in remineralizing molar incisor hypomineralization (MIH). Methods: Two lesion-bearing enamel blocks were produced from each of thirty extracted permanent molars diagnosed with MIH. Sixty produced blocks were randomly assigned to two groups (30/group): 20% HAP or 1450 ppm fluoride toothpaste. Each group was subdivided into, etched (n=20), with lesion surface treated with 32% phosphoric acid-etchant for 5 seconds, and unetched (n=10). Blocks were cemented into intra-oral appliances (2 blocks/appliance) worn full-time by 15 subjects. Subjects used the toothpastes in a two-phase crossover manner, lasting 14 days per phase, after one-week washout period. Baseline and post-treatment mineral density (MD) was quantified using microcomputed tomography. Results: Overall, both groups showed statistically significant (paired t-test; p<.001) net-gain when MD was compared pre-treatment and post-treatment. HAP: pre-treatment (1.716±0.315) and post-treatment (1.901±0.354), Fluoride: pre-treatment (1.962±0.363) and post-treatment (2.072±0.353). Independent t-test demonstrated a practically significantly (≥10%) higher percentage remineralization with HAP toothpaste (26.02±20.68) compared with fluoride toothpaste (14.64±9.60). Higher percentage remineralization was observed in etched than unetched samples. Conclusion: The tested toothpaste based on hydroxyapatite can remineralize MIH lesions. Pre-treating the tooth surface with acid-etchant enhanced remineralization.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Remineralization of Molar Incisor Hypomineralization (MIH) with a Hydroxyapatite Toothpaste: an in-situ study

Farah

Liu

Phillips

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Tooth formation during pregnancy is the critical period for tetracycline staining due to tetracycline intake during pregnancy [13]. It has been proposed that exposure to dioxins may lead to an elevated risk of molar incisor hypomineralization (MIH) [14]. Any changes in the mineralization of the teeth have permanent consequences and may lead to a poor tooth structure and an easier occurrence of caries.…”

Section: Introductionmentioning

confidence: 99%

Impact of school for future parents and first preventive examination in the first year of life on oral habits

2023

Journal of Clinical Pediatric Dentistry

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Pregnancy is an ideal time to promote the primary prevention of early childhood caries. It is crucial to have a child’s first dental examination in the first year of life. The aim of this study was to find out how the School for future parents and the child’s first dental examination affect children’s oral habits. A specialist pediatric dentist was involved in the implementation of the School for future parents and the courses and on timely care for the good oral health of the child. We examined all one- and two-year-olds whose parents responded positively to a dental examination for their child. During the first examination, we considered attendance at the School, how the parents booked the dental examination, what the child drinks when thirsty, how many times a day they brush their children’s teeth and toothpaste use. During the second examination, we considered what the child drinks when thirsty, how many times a day the parents brush their children’s teeth and toothpaste use. The results showed that participants in the School were more likely to book their children’s first preventive, consultative dental examination (p < 0.001), brush their children’s teeth, and use toothpaste (p < 0.001) than parents who did not attend the school. However, there was no difference between the two groups regarding what parents gave their children to drink when they were thirsty (p = 0.69). In the child’s second year, all the parents used toothpaste, brushed their children’s teeth more often, and their children drank sweet drinks more often than before the first examination (p < 0.001). We have succeeded in raising awareness of good oral habits among parents and children (the frequency of brushing children’s teeth and the using toothpaste), but not changed the behavior in the type of drinking against thirst.

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“…In modern dentistry, minimally invasive treatment is gaining popularity because it preserves dental tissue to the greatest extent and effectively reduces patients’ anxiety. As a microinvasive technique, the existing infiltration resin can inhibit the progression of early caries and improve the esthetics of whitish discoloration ( Eckstein et al, 2015 ; Borges et al, 2016 ; Peters et al, 2019 ; Olmo-González et al, 2020 ). However, its main component, TEGDMA, is easily released from the matrix and causes cytotoxic reactions ( Geurtsen and Leyhausen, 2001 ; Bakopoulou et al, 2011 ), highlighting the need to pay specific attention to infiltration resin’s biosafety issues since it is commonly used to treat children and adolescents ( Gölz et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

A novel dental infiltration resin based on isosorbide-derived dimethacrylate with high biocompatibility, hydrolysis resistance, and antibacterial effect

Yang

Sui

Cui

et al. 2022

Front. Bioeng. Biotechnol.

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Objectives: The available infiltration resin has raised biosafety and treatment stability concerns because of the cytotoxicity of the main component, TEGDMA, and its susceptibility to hydrolysis in the oral environment. This study aimed to develop a TEGDMA-free infiltration resin to overcome these drawbacks.Methods: Using the synthetic bioderived monomer bis(methacrylate) isosorbide (IBM) and the zwitterionic compound 2-methacryloyloxyethyl phosphorylcholine (MPC), a novel infiltrant IBMA was developed and preferentially selected. We investigated the performance of the IBMA resin regarding cytotoxicity, antibiofilm adhesion, and hydrolysis resistance and further verified its ability to restore the demineralized enamel and stability of the infiltrated area under artificial aging conditions.Results: Compared with the commercial TEGDMA-based infiltration resin ICON, IBMA not only demonstrated similar enamel morphologic and esthetic restorative effects in chalky lesions but also exhibited favorable cell viability, durable Streptococcus mutans UA159 biofilm-repellent performance, and higher enamel microhardness (204.0 ± 5.12 HV) of the infiltrated enamel. Specifically, because of the high crosslink density [(47.77 ± 5.76) ×103 mol/mm3] and low water sorption [12.79 ± 2.56 µg/mm3] of the polymer network, the IBMA resin was more resistant to hydrolysis than ICON, which prevents the disruption of the infiltrant’s micropore-blocking effect after aging. Enamel lesions treated with IBMA demonstrated good color stability after the tea-staining challenge, which was significantly better than that in the ICON group.Conclusion: Based on these findings, the IBMA resin exhibits favorable cell viability, hydrolysis resistance, and biofilm-repellent properties, which alleviates the defects of traditional TEGDMA systems. Therefore, it is a better alternative for microinvasive treatment involving early caries and enamel whitish discoloration.

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Dental management strategies for Molar Incisor Hypomineralization

Cited by 7 publications

References 107 publications

Remineralization of Molar Incisor Hypomineralization (MIH) with a Hydroxyapatite Toothpaste: an in-situ study

Remineralization of Molar Incisor Hypomineralization (MIH) with a Hydroxyapatite Toothpaste: an in-situ study

Impact of school for future parents and first preventive examination in the first year of life on oral habits

A novel dental infiltration resin based on isosorbide-derived dimethacrylate with high biocompatibility, hydrolysis resistance, and antibacterial effect

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