Dental mesenchymal stem cells

Sharpe, Paul T.

doi:10.1242/dev.134189

Cited by 268 publications

(245 citation statements)

References 59 publications

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“…They differentiate into the pulp cells and odontoblasts that form dentin as the tooth grows, in coordination with the epithelial cells. Previous studies have shown that peripheral nerve-associated glial cells can also serve as mesenchymal stem cells for maintaining incisor pulp tissue homeostasis and repair (Kaukua et al, 2014), with these dental mesenchymal stem cells offering potential clinical applications (reviewed by Sharpe, 2016).…”

Section: Dental Stem Cells and The Transition From Crown To Root Devementioning

confidence: 99%

Cellular and molecular mechanisms of tooth root development

2017

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The tooth root is an integral, functionally important part of our dentition. The formation of a functional root depends on epithelialmesenchymal interactions and integration of the root with the jaw bone, blood supply and nerve innervations. The root development process therefore offers an attractive model for investigating organogenesis. Understanding how roots develop and how they can be bioengineered is also of great interest in the field of regenerative medicine. Here, we discuss recent advances in understanding the cellular and molecular mechanisms underlying tooth root formation. We review the function of cellular structure and components such as Hertwig's epithelial root sheath, cranial neural crest cells and stem cells residing in developing and adult teeth. We also highlight how complex signaling networks together with multiple transcription factors mediate tissue-tissue interactions that guide root development. Finally, we discuss the possible role of stem cells in establishing the crown-to-root transition, and provide an overview of root malformations and diseases in humans.

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Section: Dental Stem Cells and The Transition From Crown To Root Devementioning

confidence: 99%

Cellular and molecular mechanisms of tooth root development

2017

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“…MSCs can be obtained from not only bone marrow but also medical wastes such as adipose tissue [57,58], umbilical tissue [59][60][61][62], and dental pulp [63]. MSCs are positive for the common markers CD73, CD90, and CD105; however, they are negative for the endothelial marker CD31 and hematopoietic marker CD45 [56,64].…”

Section: Mscsmentioning

confidence: 99%

Status of and candidates for cell therapy in liver cirrhosis: overcoming the “point of no return” in advanced liver cirrhosis

Terai

Tsuchiya

2016

J Gastroenterol

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The treatment of liver cirrhosis is currently being standardized and developed specifically to reduce activation of hepatic stellate cells (HSCs), inhibit fibrosis, increase degradation of matrix components, and reduce activated myofibroblasts. Cell therapy can be applied in the treatment of liver cirrhosis; however, the characteristic features of this therapy differ from those of other treatments because of the involvement of a living body origin and production of multiple cytokines, chemokines, matrix metalloproteinases (MMPs), and growth factors. Thus, cell therapies can potentially have multiple effects on the damaged liver, including alleviating liver cirrhosis and stimulating liver regeneration with affecting the host cells. Cell therapies initially involved autologous bone marrow cell infusion, and have recently developed to include the use of specific cells such as mesenchymal stem cells and macrophages. The associated molecular mechanisms, routes of administration, possibility of allogeneic cell therapy, and host conditions appropriate for cell therapies are now being extensively analyzed. In this review, we summarize the status and future prospects of cell therapy for liver cirrhosis.

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“…Mesenchymal stromal cells (MSCs) are multipotent progenitors derived from different sources, including bone marrow (BM) , adipose tissue ( Van Pham et al, 2014), umbilical cord (UC) blood (Sibov et al, 2012), UC (Van Pham et al, 2016), Wharton's jelly (Ducret et al, 2016), and other tissues (Ducret et al, 2016;Pelekanos et al, 2016;Sharpe, 2016). Although, bone marrow-derived MSCs (BMMSCs) are a popular source of MSCs for research and clinical applications, there are now alternative sources of MSCs, including adipose tissue-derived stem cells (ADSCs) and umbilical cord-derived mesenchymal stem cells (UCMSCs).…”

Section: Introductionmentioning

confidence: 99%

Umbilical cord-derived stem cells (ModulatistTM) show strong immunomodulation capacity compared to adipose tissue-derived or bone marrow-derived mesenchymal stem cells

Pham¹,

Vu²,

Phan³

2016

Biomed Res Ther

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Abstract-Introduction:Mesenchymal stem cells (MSCs) show great promise in regenerative medicine. Clinical applications of MSCs have recently increased significantly, especially for immune diseases. Autologous transplantation is considered a safe therapy. However, its main disadvantages are poor stability and quality of MSCs from patient to patient, and labor-intensive and time-consuming culture procedures. Therefore, allogeneic MSC transplantation has recently emerged as a potential replacement for autologous transplantation. "Off the shelf" MSC products, or socalled "stem cell drugs", have rapidly developed; these products have already been approved in various countries, including Canada, Korea and Japan. This study aims to evaluate a new stem cell product or "drug", termed Modulatist TM , derived from umbilical cord mesenchymal stem cells (UCMSCs), which have strong immunomodulatory properties, compared to bone marrow-derived MSCs (BMMSCs) or adipose tissue-derived stem cells (ADSCs). Methods: Modulatist TM was produced from MSCs derived from whole umbilical cord (UC) tissue (which includes Wharton's jelly and UC), according to GMP compliant procedures. Bone marrow-and adipose tissue-derived MSCs were isolated and proliferated in standard conditions, according to GMP compliant procedures. Immunomodulation mediated by MSCs was assessed by allogenic T cell suppression and cytokine release; role of prostaglandin E2 in the immunomodulation was also evaluated. Results: The results showed that Modulatist TM exhibited stronger immunomodulation than BMMSC and ADSC in vitro. Modulatist TM strongly suppressed allogeneic T cells proliferation and decreased cytokine production, compared to BMMSCs and ADSCs. Conclusion: Modulatist TM is a strong immunomodulator and promising MSC product. It may be useful to modulate or treat autoimmune diseases.

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Dental mesenchymal stem cells

Cited by 268 publications

References 59 publications

Cellular and molecular mechanisms of tooth root development

Cellular and molecular mechanisms of tooth root development

Status of and candidates for cell therapy in liver cirrhosis: overcoming the “point of no return” in advanced liver cirrhosis

Umbilical cord-derived stem cells (ModulatistTM) show strong immunomodulation capacity compared to adipose tissue-derived or bone marrow-derived mesenchymal stem cells

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