Dental Resin-Based Materials with Antibacterial Properties: Contact Inhibition and Controlled Release

Imazato, Satoshi; Kitagawa, Haruaki

doi:10.1007/978-3-030-67388-8_10

Cited by 5 publications

(13 citation statements)

References 35 publications

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Section: Introductionmentioning

confidence: 99%

“…The development of new-generation dental materials with antibacterial activity is a topic of considerable interest and ongoing research in the field of dentistry [1]. Among the several approaches available for imparting antibacterial effects to dental resins, one useful technology immobilizes antibacterial components on materials [1][2][3]. These materials exhibit a phenomenon known as "contact inhibition", where bacteria that come into contact with the material surfaces are suppressed, without the release of any active components [1].…”

Section: Introductionmentioning

confidence: 99%

“…Among the several approaches available for imparting antibacterial effects to dental resins, one useful technology immobilizes antibacterial components on materials [1][2][3]. These materials exhibit a phenomenon known as "contact inhibition", where bacteria that come into contact with the material surfaces are suppressed, without the release of any active components [1]. This technology contains the utilization of a polymerizable bactericide, such as resin monomers based on quaternary ammonium compounds (QACs) [2].…”

Section: Introductionmentioning

confidence: 99%

“…MDPB was synthesized by combining alkylpyridinium (a QAC) with a methacryloyl functional group. The alkylpyridinium in the MDPB is responsible for its antibacterial effects, and the methacryloyl functional group can copolymerize with other monomers used for dental resins [1,3]. Bactericides immobilized via the polymerization of MDPB covalently bind to dental resins and cannot be released.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, resin composites containing MDPB exhibit long-term inhibition against microorganisms on their surfaces [4]. However, the immobilized bactericide exhibits limited molecular movement and interferes with the structure of the bacterial surface through direct contact; therefore, its effect is essentially Materials 2024, 17, 896 2 of 11 bacteriostatic rather than bactericidal [1]. To obtain bactericidal effects, the density of the immobilized QACs exposed on the outer surface must be high, as shown by quaternary ammonium polyethyleneimine (QPEI) nanoparticles [5].…”

Section: Introductionmentioning

confidence: 99%

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Development of Antibacterial Resin Composites Incorporating Poly(METAC) Clusters

Kohno,

Kitagawa,

Tsuboi

et al. 2024

Materials

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This study examined the antibacterial effects and physical properties of a novel resin composite incorporating poly[{2-(methacryloyloxy)ethyl}trimethylammonium chloride] (poly(METAC)), a methacrylate cationic polymer comprising quaternary ammonium compounds (QACs). Resin composites incorporating poly(METAC) were fabricated by adding 6 wt.% METAC aqueous solution to a commercially available resin composite. The FE-SEM/EDS and Raman spec-troscopy analyses showed that METAC was assembled and polymerized in the resin composites after curing. The antibacterial effect was evaluated by inoculating Streptococcus mutans or Strepto-coccus sobrinus suspensions on the surface of cured resin composites, and the experimental resin composites incorporating poly(METAC) clusters exhibited bactericidal effects even after 28 days of ageing. The physical properties of the experimental resin composites were within the ISO-stipulated ranges. Newly fabricated resin composites containing the QAC-based poly(METAC) cluster ex-hibited long-term bactericidal effects against oral bacteria on their surfaces and demonstrated ac-ceptable physical properties for clinical use.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of Antibacterial Resin Composites Incorporating Poly(METAC) Clusters

Kohno,

Kitagawa,

Tsuboi

et al. 2024

Materials

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Metal-doped silicate and phosphate glasses for antibacterial dental biomaterials

Kitagawa,

Kohno,

Deng

et al. 2023

Biomaterial Investigations in Dentistry

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Owing to the development of glass 45S5 (Bioglass®) comprising 45 mol% SiO 2 , 24.5 mol% Na 2 O, 24.5 mol% CaO, and 6 mol% P 2 O 5 , different compositions of silicate glasses have been developed. When these silicate glasses contact an aqueous environment, such as body fluids, they induce apatite layer formation on their surfaces owing to ion exchange. In addition to promoting hard tissue formation, researchers have sought to enhance the antibacterial properties of these glasses, thereby resulting in the development of metal-doped silicate glasses. The addition of antibacterial metals (silver, copper, zinc, and gallium) to silicate glass offers a promising avenue for combating oral pathogens. In recent years, there has been growing interest in metal-doped phosphate glasses. The release of metal ions can be regulated by modifying the dissolution rate of the phosphate glasses. This review summarizes the metal-doped silicate and phosphate glasses that confer antibacterial activity. Future strategies for the development of dental biomaterials that incorporate metal-doped glass and exhibit antibacterial effects are discussed.

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Three-year clinical performance of direct Restorations using Low Shrinkage Giomer versus Nanohybrid Resin Composite

Toz-Akalin,

Öztürk-Bozkurt,

Kusdemir

et al. 2023

Preprint

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Objectives The objective of this investigation was to compare the clinical performances of nanohybrid and low-shrinkage bioactive resin composites. Materials and methods Totally, 35 pairs of restorations performed with either low-shrinkage bioactive Giomer (Beautifil II LS, Shofu Inc.) or nanohybrid (Clearfil Majesty Posterior) resin composites in 35 patients by two operators using the relevant adhesives: FL-Bond II (Shofu Inc) and Clearfil SE Bond (Kuraray), according to each manufacturer’s instructions. Two clinicians assessed the restorations two weeks after restorative procedures (baseline), after six months, one, two and three years using FDI criteria (Scores 1–5). Data were analyzed using the marginal homogeneity and the McNemar test. Survival Rate was calculated using Kaplan-Meier survival analysis and the survival of the two groups was compared with the Log-Rank test (p = 0.05). Results Mean observation period was 37.7 ± 6.8 months. All restorations completed their 3-years follow up. All criteria were rated mainly with high (1 or 2) scores for quality in both groups. Only one restoration from low-shrinkage Giomer restorative group was accepted as failure due to retention loss of the restorative. Conclusion Over the three-year follow-up, both the Giomer and the nanohybrid resin composite restorations’ performances were similar and clinically acceptable. Clinical relevance Low-shrinkage bioactive material Giomer resin composite exhibited similar clinical performance to the nanohybrid resin composite after three years in service, with both materials displaying minor surface deteriorations at three-year recall. Trial registration Clinical Trial Registration Number: NCT02823769.

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Dental Resin-Based Materials with Antibacterial Properties: Contact Inhibition and Controlled Release

Cited by 5 publications

References 35 publications

Development of Antibacterial Resin Composites Incorporating Poly(METAC) Clusters

Development of Antibacterial Resin Composites Incorporating Poly(METAC) Clusters

Metal-doped silicate and phosphate glasses for antibacterial dental biomaterials

Three-year clinical performance of direct Restorations using Low Shrinkage Giomer versus Nanohybrid Resin Composite

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