Dental Treatment in Patients with Leukemia

Zimmermann, Caroline; Meurer, Maria Inês; Grando, Liliane Janete; Moral, Joanita Angela Gonzaga Del; Rath, Inês Beatriz da Silva; Tavares, Silvia Schaefer

doi:10.1155/2015/571739

Cited by 52 publications

(94 citation statements)

References 34 publications

(80 reference statements)

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“…[16][17][18][19][20] Mucositis is most frequently induced by a reduced number of white blood cells, the use of cytotoxic antibiotics and by alkylating factors. 16,17 A significant decrease in salivary S-IgA following chemotherapy in children with leukemia was reported by Karolewska et al, although the authors did not report differences in the S-IgA concentration in comparison with the control group prior to anti-tumor treatment. According to those authors, a statistically significant low salivary S-IgA level was maintained after chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…9,10,35 The participation of dentists in multidisciplinary teams treating children with ALL can greatly contribute to better health protection for these patients. 16 At the same time, it must be emphasized that the immunoregulatory mechanisms of cytokines and immunoglobulins involved in oral inflammations play a special role in protecting the host and maintaining oral homeostasis. Saliva may become a good source for detecting pro-inflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

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Oral mucositis and saliva IgA, IgG and IgM concentration during anti-tumor treatment in children suffering from acute lymphoblastic leukemia

Pels¹

2017

Adv Clin Exp Med

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oral mucositis and saliva IgA, IgG and IgM concentration during anti-tumor treatment in children suffering from acute lymphoblastic leukemia

Pels¹

2017

Adv Clin Exp Med

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“…Combination of chemotherapy, radiation therapy and bone marrow transplant are involved in treatment of leukemia [6]. But these treatments have limitations because of a high probability of relapse and toxicity.…”

Section: Aimmentioning

confidence: 99%

The Mechanistic Antitumor Study of Myricanol 5-Fluorobenzyloxy Ether in Human Leukemic Cell Hl-60

Dai

Fan

Ren³

et al. 2017

Future Med. Chem.

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Aim:The aim of the study was to explore the growth inhibitory effect of myricanol 5-fluorobenzyloxy ether (5FEM) and the underlying mechanism in human leukemic cells HL-60. Materials & methods: 5FEM was obtained by chemical modification of myricanol with fluorobenzyloxy ether at the OH(5) position. The cytotoxicity, cell apoptosis, cell cycle and the expression of key apoptosis-related genes in HL-60 were evaluated. Results & conclusion: 5FEM can significantly inhibited growth of HL-60 cells, increased the G2/M population and upregulated the expression of Bax, Fas, FasL, caspase-9 and p21 and downregulated that of Bcl-2 and survivin. The results enhance our understanding of 5FEM and aid the discovery of novel myricanol derivatives as potential antitumor agents. The incidence and mortality of cancer have been increasing in China [1]. About 4,292,000 new cases of cancer and 2,814,000 cancer-related deaths were estimated in China in 2015 [2]. It was reported that leukemia is the sixth leading cause of cancer death [3].Both genetic and environmental factors have been reported to cause of leukemia [4,5]. Combination of chemotherapy, radiation therapy and bone marrow transplant are involved in treatment of leukemia [6]. But these treatments have limitations because of a high probability of relapse and toxicity. Traditional Chinese medicine and natural plants have been used in the treatment of cancer for thousands of years in China. Owing to its minor side effects and good curative efficacy, the screening of anticancer drugs from traditional Chinese herbal medicine has increased considerably over the past few years [7,8].Myrica rubra (Lour.) Sieb. Et Zucc., a myricaceae Myrica plant, found in China and other Asian countries. Because of its biological properties, the bark of M. rubra is used in Chinese folk medicine [9][10][11]. Myricanol is a cyclic diarylheptanoid isolated from the bark of M. rubra. Diarylheptanoids exhibit various biological activities, including antitumor [12], antiviral [13], antioxidant [14] and anti-inflammatory [15] owing to its unique chemical structure. Our previous studies have shown that myricanol significantly inhibits the proliferation of human lung adenocarcinoma (A549), hepatoma (HepG2) and human promyelocytic leukemia (HL-60) cells. Further, it increased the caspase-3, caspase-9, Bax and p21 expression and decreased the expressions of Bcl-2 at the mRNA and protein levels [16]. Myricanol significantly induced tumor growth inhibitory effects on the xenografts of lung adenocarcinoma A549 by upregulating the expression of Bax and downregulating that of survivin, Bcl-2, VEGF and HIF-1α. The experimentation has indicated that the possible antitumor effects of myricanol are via the mitochondrial apoptosis pathway [17].In order to improve anticancer effect of myricanol, and to further explore the structure-activity relationship of myricanol and discover novel myricanol derivatives as antitumor agents, some novel myricanol derivatives, such as 5-fluorobenzyloxy ether (5FEM), myricanol 5-chlorobe...

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“…Anticoagulation therapy can be reinstituted 6‐12 h after completion of the dental surgical treatment . If the platelet count is less than 50 000 cells/mm 3 , invasive procedures should be postponed and platelet transfusion may be indicated prior to the procedure (Figure ) …”

Section: Introductionmentioning

confidence: 99%