Dentatin triggers ROS-mediated apoptosis, G0/G1 cell cycle arrest and release of Th1-related cytokines in colorectal carcinoma cells

Zulpa, Ahmad Khusairy; Barathan, Muttiah; Vellasamy, Kumutha Malar; Mariappan, Vanitha; Vadivelu, Jamuna

doi:10.1080/16583655.2023.2194231

Cited by 1 publication

(1 citation statement)

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“…Moreover, various clausenawalline alkaloids were found to be present in acetone extract from Clausena wallichii twigs [ 75 ]. Andas et al [ 44 ] purified dentatin carbazole from Clausena excavate root extract. The mechanism studies in this work suggested that dentatin inhibited nuclear factor kappa B (NF-κB) and increased caspase 3 and 9 expressions in HepG2 cells.…”

Section: Anticancer Alkaloids From Plantsmentioning

confidence: 99%

Therapeutic Role of Alkaloids and Alkaloid Derivatives in Cancer Management

2023

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Cancer is a neoplastic disease that remains a global challenge with a reported prevalence that is increasing annually. Though existing drugs can be applied as single or combined therapies for managing this pathology, their concomitant adverse effects in human applications have led to the need to continually screen natural products for effective and alternative anticancer bioactive principles. Alkaloids are chemical molecules that, due to their structural diversity, constitute a reserve for the discovery of lead compounds with interesting pharmacological activities. Several in vitro studies and a few in vivo findings have documented various cytotoxic and antiproliferative properties of alkaloids. This review describes chaetocochin J, neopapillarine, coclaurine, reflexin A, 3,10-dibromofascaplysin and neferine, which belong to different alkaloid classes with antineoplastic properties and have been identified recently from plants. Despite their low solubility and bioavailability, plant-derived alkaloids have viable prospects as sources of viable lead antitumor agents. This potential can be achieved if more research on these chemical compounds is directed toward investigating ways of improving their delivery in an active form close to target cells, preferably with no effect on neighboring normal tissues.

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Section: Anticancer Alkaloids From Plantsmentioning

confidence: 99%