In the present study, we sought to: (a) analyze the p53 gene status in dentigerous cysts (DC) associated with supernumerary teeth (ST) in a pair of siblings with ST, of whom one developed a DC; and (b) conduct a narrative review of the literature on ST associated with DC. Blood samples were obtained, and the isolated DNA was used to amplify exons 4-8 of the p53 gene using specific primers, and subsequently sequenced.No mutations were identified in the coding regions of the p53 gene. A review of the literature revealed a prevalence of DC associated with ST to be as high as 13.6%, and that 83% of the case reports performed enucleation of DC and removal of ST. Supernumerary teeth (ST) can be defined as "any tooth or odontogenic structure that is formed from a tooth germ in excess of the usual number for any given region of the dental arch". 5 They might be single or multiple or unilateral or bilateral in distribution, and can occur in both arches of the primary, mixed, and permanent dentitions. 6 The reported prevalence of ST in the general population is possibly higher than that reported in the literature, and ranges from approximately 3% to 6% or even higher, with a gender predilection for males. 7 The majority of ST occur in the premaxilla, with an inverted orientation;this is the reason why they remain unerupted. 6 ST can cause a range of complications, from crowding to cyst formation.