Dentin dysplasia Type II: absence of Type III collagen in dentin

Ranta, Helena; Lukinmaa, Pirjo‐Liisa; Knif, Janna

doi:10.1111/j.1600-0714.1990.tb00817.x

Cited by 17 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an earlier study, reticulin fibers have been found to be abundant in dentin matrix in DD type II (6), and dehcate fibers were occasionally observed in the primary tooth examined in the present study as well. However, our finding that the affected dentin contains abnormally coarse collagen fibers, is in good agreement with the negative immunostaining for type III (pro-)collagen (5). The present findings further suggest that even though the affected permanent teeth have normal coronal dentin, the structural aberrations of their radicular dentin, compared to those found in the primary teeth, are even more severe.…”

Section: Discussionsupporting

confidence: 91%

“…The fibers, which were found to form large atubuIar areas, seemed to be either hazardously scattered in the loose-textured dentin matrix or they seemed to form dense, curvy bundles. The normal tubular appearance ofthe coronal dentin, and the abnormal, often atubular, structure ofthe affected radicular dentin in DD type II have been reported in a number of earlier studies (1,(3)(4)(5).…”

Section: Discussionmentioning

confidence: 75%

“…Still, there are occasional unclassifiable cases as well as classified cases with unusual characteristics (16)(17)(18). On the other hand, similar features in teeth from patients with for example DD type II, and dentinogenesis imperfecta associated with osteogenesis imperfecta, have been found at the light microscopic level (5) and when studied by SEM (7). To get closer to the understanding ofthe basic defect (s) in the different types of inherited dentin disorders, a systematic comparative study by means of TEM would be of great value.…”

Section: Discussionmentioning

confidence: 94%

See 2 more Smart Citations

Transmission electron microscopic appearance of dentin matrix in type II dentin dysplasia

Waltimo

Ranta²,

Lukinmaa

1991

European J Oral Sciences

Self Cite

View full text Add to dashboard Cite

Waltimo J, Ranta H, Lukinmaa P-L: Transmission electron microscopic appearance of dentin matrix in type II denlin dysplasia. ScandJ DenL Res 1991; 99: 349-56.Abstract -Dentin matrix of demineralized primary and permanent teeth with type II dentin dysplasia was studied by transmission electron microscopy. The coronal dentin of a maxillary third molar exhibited a normal structure. In the radicular dentin, tubules v\'ere few in number; the major part of the dentin was composed of thick, curvy bundles of cross-striated collagen fibers. In the most aberrant areas ofthe radicular dentin, coarse collagen fibers measuring up to 140 nm in thickness were obsen'ed. The dentin ofthe primary tooth showed a similar, but somewhat less irregular, structure.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Transmission electron microscopic appearance of dentin matrix in type II dentin dysplasia

Waltimo

Ranta²,

Lukinmaa

1991

European J Oral Sciences

Self Cite

View full text Add to dashboard Cite

show abstract

“…A careful examination of these cases shows that DGI-II is often present in other members of the family related to the patient or in the patient himself with also discoloration of their permanent teeth. 55 An allelic relation between these two pathologies was proposed by McDougall 38 and Dean based on linkage analysis. 56 Description of DSPP mutation in a patient affected by DD-II confirmed this hypothesis and explained these clinical similarities.…”

Section: Dentin Dysplasia Type I or Radicularmentioning

confidence: 99%

Isolated dentinogenesis imperfecta and dentin dysplasia: revision of the classification

Molla¹,

Fournier²,

Berdal³

2014

Eur J Hum Genet

111

134

View full text Add to dashboard Cite

Dentinogenesis imperfecta is an autosomal dominant disease characterized by severe hypomineralization of dentin and altered dentin structure. Dentin extra cellular matrix is composed of 90% of collagen type I and 10% of non-collagenous proteins among which dentin sialoprotein (DSP), dentin glycoprotein (DGP) and dentin phosphoprotein (DPP) are crucial in dentinogenesis. These proteins are encoded by a single gene: dentin sialophosphoprotein (DSPP) and undergo several posttranslational modifications such as glycosylation and phosphorylation to contribute and to control mineralization. Human mutations of this DSPP gene are responsible for three isolated dentinal diseases classified by Shield in 1973: type II and III dentinogenesis imperfecta and type II dentin dysplasia. Shield classification was based on clinical phenotypes observed in patient. Genetics results show now that these three diseases are a severity variation of the same pathology. So this review aims to revise and to propose a new classification of the isolated forms of DI to simplify diagnosis for practitioners.

show abstract

“…The permanent teeth appear normal with respect to shape, form, and color in most cases, although the pulp cavities of permanent teeth may show a thistle‐tube deformity and commonly contain pulp stones. Unlike in DD‐I, the roots are of normal length and idiopathic periapical radiolucencies are not observed . To date, fewer than 90 families/cases of DD have been reported in the literature, including two cases of DD‐II and one case of DD‐III.…”

Section: Classification Of Hereditary Dentin Disordersmentioning

confidence: 99%

Dentin disorders: anomalies of dentin formation and structure

Coster¹

2009

Endodontic Topics

View full text Add to dashboard Cite

Dentin defects represent a cluster of relatively rare heritable disorders affecting the formation and mineralization of dentin. Major clinical features include loss of enamel with extreme wear of exposed dentin, opalescent tooth discoloration, short roots with pulpal calcification and increased tooth mobility, and frequent periapical radiolucencies. Historically, these inherited conditions have been classified by Shields et al. (1) as either dentinogenesis imperfecta (DGI) types I, II and III, or dentin dysplasia (DD) types I and II. DGI type I is now universally designated as osteogenesis imperfecta with dentinogenesis imperfecta (OI/DGI) and is caused by type I collagen mutations. Among the genes expressing the non‐collagenous proteins in dentin, only the DSPP gene has been implicated in the etiology of DD type II and all DGI types, suggesting that heritable dentin defects can be viewed as a continuum rather than as distinct disease entities. Dental treatment strategies should aim to preserve the affected dentitions by protecting teeth from wear, restoring them to compliance with the specific structural characteristics of the defective dentin, and anticipating early tooth loss. Endodontic treatment of the affected teeth is very challenging because of the peculiar pulp morphology and most often has poor prognosis. If conventional therapy is not an option, periapical curettage and retrograde filling is a possible alternative, except in the case of teeth with short roots.

show abstract

Dentin dysplasia Type II: absence of Type III collagen in dentin

Cited by 17 publications

References 24 publications

Transmission electron microscopic appearance of dentin matrix in type II dentin dysplasia

Transmission electron microscopic appearance of dentin matrix in type II dentin dysplasia

Isolated dentinogenesis imperfecta and dentin dysplasia: revision of the classification

Dentin disorders: anomalies of dentin formation and structure

Contact Info

Product

Resources

About