Dentin permeability and pulpal response to EDTA

Lindemann, Robert A.; Hume, W.R.; Wolcott, Robert B.

doi:10.1016/0022-3913(85)90506-2

Cited by 12 publications

(15 citation statements)

References 13 publications

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“…Acute exacerbation did not seem to occur more frequently than with other irrigants. Further studies have indicated that EDTA is not capable of destroying collagen (Lindemann et al . 1985).…”

Section: Biocompatibility Of Chelating Agentsmentioning

confidence: 99%

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Chelating agents in root canal treatment: mode of action and indications for their use

2003

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Chelating agents were introduced into endodontics as an aid for the preparation of narrow and calcified root canals in 1957 by Nygaard-Østby. A liquid solution of ethylenediaminetetraacetic acid (EDTA) was thought to chemically soften the root canal dentine and dissolve the smear layer, as well as to increase dentine permeability. Although the efficacy of EDTA preparations in softening root dentine has been debated, chelator preparations have regained popularity recently. Almost all manufacturers of nickel-titanium instruments recommend their use as a lubricant during rotary root canal preparation. Additionally, a final irrigation of the root canal with 15-17% EDTA solutions to dissolve the smear layer is recommended in many textbooks. This paper reviews the relevant literature on chelating agents, presents an overview of the chemical and pharmacological properties of EDTA preparations and makes recommendations for their clinical use.

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Section: Biocompatibility Of Chelating Agentsmentioning

confidence: 99%

“…1985). When the dentine is intact, the effect on the pulp seems to be negligible (Lindemann et al . 1985) so that EDTA can also be recommended as a conditioning agent prior to application of dentine bonding (Cao et al .…”

Section: Biocompatibility Of Chelating Agentsmentioning

confidence: 99%

Chelating agents in root canal treatment: mode of action and indications for their use

2003

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“…The direct application of bonding agents (Pameijer & Stanley 1995), EDTA and other dentine conditioning agents has long been an issue for pulpal viability. The cytotoxicity of EDTA has led to the recommendation for it not to be used in pulp exposures or very deep cavity preparations (Lindemann et al. 1985).…”

Section: Discussionmentioning

confidence: 99%

Comparison of operative procedure variables on pulpal viability in an ex vivo model

et al. 2008

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“…Much controversy exists over the depth to which these conditioning agents penetrate the residual dentin and whether they injure the underlying pulp (6,(11)(12). Retief (13) has reported a severe reaction to phosphoric acid conditioner in monkeys and Macko et al (4) in humans, while Mjor et al (16) have reported little response to a variety of acids in the same animal. In vitro studies by Lindemann et al (16) in extracted teeth have shown that the perfusate from cavities in teeth treated with citric acid was strongly cytotoxic, while those from EDTA-treated teeth was not.…”

mentioning

confidence: 99%

“…Retief (13) has reported a severe reaction to phosphoric acid conditioner in monkeys and Macko et al (4) in humans, while Mjor et al (16) have reported little response to a variety of acids in the same animal. In vitro studies by Lindemann et al (16) in extracted teeth have shown that the perfusate from cavities in teeth treated with citric acid was strongly cytotoxic, while those from EDTA-treated teeth was not. In vivo studies are complicated by the possible invasion of bacteria, which themselves may cause severe infiammation, into conditioned dentin (17).…”

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confidence: 99%

Penetration of dentin by different conditioners in vitro: a quantitative study

Meryon

Tobias

Johnson

1988

Dental Traumatology

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Conditioning agents are known to remove the smear layer that forms on cut dentin with the resultant opening of the orifices of the dentinal tubules. However, much controversy exists over the depth to which these agents penetrate the residual dentin and whether they might damage the underlying pulp. In view of the enormous technical difficulties of studying the depth of penetration of such agents in vivo, an in vitro study was undertaken. Dentin slices of known thickness were prepared with an intact smear layer on both surfaces. The upper surface was treated with the test conditioner, and the depth of penetration was assessed using SEM by the degree of removal of the dentin plugs blocking the orifices of the dentin tubules in the lower untreated surface. No significant penetration of 200 μm slices occurred and only slight penetration of 100 and 50 μm slices. There was little difference in the degree of penetration achieved by the 5 agents studied. The results presented suggest that the chemical toxicity of the conditioners tested will not damage the pulp if the residual dentin depth is greater than 200 μm.

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Dentin permeability and pulpal response to EDTA

Cited by 12 publications

References 13 publications

Chelating agents in root canal treatment: mode of action and indications for their use

Chelating agents in root canal treatment: mode of action and indications for their use

Comparison of operative procedure variables on pulpal viability in an ex vivo model

Penetration of dentin by different conditioners in vitro: a quantitative study

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