Dentine Hypersensitivity

정현주,; 박승호,

doi:10.1007/978-3-319-14577-8

Cited by 20 publications

(7 citation statements)

References 9 publications

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“…According to Hill and Gillam [1] despite the vast array of commercial products designed either as professionally applied products or techniques (Dentist applied) or as over-the counter products (OTC) (Home use) there is no universally accepted product that can completely resolve DH. The desensitising technologies evaluated in the current in vitro study included a novel self-assembling peptide matrix (SAPM) gel and three selected desensitizing toothpastes with established tubular occluding properties namely 1) a technology consisting of arginine, a naturally occurring amino acid, and an insoluble calcium compound, in the form of calcium carbonate (CSP), 2) a 45S5 bioactive glass formulation (SRP) and 3) a strontium acetate formulation (SRR).…”

Section: Discussionmentioning

confidence: 99%

“…It is also important to recognise that the occlusion by the SAPM gel, does not involve any chemical or physical reaction, whereas all the other products rely on a precipitation reaction within the dentinal tubuli. For example, according to several investigators, arginine in the CSP formulation has been postulated to form a calcium arginine complex with calcium carbonate on the tooth surface and within the dentine tubules [1,4]. The chemistry of this process however is poorly understood and has not been characterized in any detail [1].…”

Section: Discussionmentioning

confidence: 99%

“…According to Hill & Gillam [1] Dentine Hypersensitivity (DH) is a clinical problem that may have impact on the Quality of Life of individuals who experience discomfort when eating and drinking hot and cold food during their day to day activities. The condition is postulated in the Hydrodynamic Theory [2] to be a result of minute fluid shifts within the dentine tubules following an external stimulus (e.g., cold, heat etc.).…”

Section: Introductionmentioning

confidence: 99%

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An In Vitro Comparison of A Novel Self-Assembling Peptide Matrix Gel and Selected Desensitizing Toothpastes in Reducing Fluid Flow by Dentine Tubular Occlusion

2020

J Dent Maxillofacial Res

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Objectives: The objective of this explorative in vitro study was to evaluate the ability of a novel self-assembling peptide matrix gel with calcium phosphate in effectively occluding dentine tubules compared to selected desensitizing toothpastes.Methods: Mid-coronal dentine discs with a thickness of 1 mm were sectioned from caries-free human molars. The discs were etched with 6% citric acid for 2 minutes, halved and subjected to a 2-minute brushing with a novel gel (SAPM) and three selected desensitizing toothpastes ([SRP], [SRR] and [CSP]). The ability of the desensitizing gel and toothpastes to occlude the dentine tubules was assessed and compared before and after brushing using Scanning Electron Microscopy (SEM) on both etched and fractured dentine surfaces. The SEM observations were supplemented by hydraulic conductance measurements using a modified Pashley model before and after tooth brushing (n=5). Results:The results demonstrated that there was a reduction in both the number and the diameter of the open dentine tubules, which was evident for all the treated dentine discs. The particles that occluded the open dentine tubules, however had different morphologies and distribution. The selfassembling peptide matrix gel (SAPM) demonstrated greater reduction in the number of open tubules compared to the other desensitizing toothpastes. Reductions in the hydraulic conductance measurements were observed for all tested materials (mean [SD, %]: SAPM 55.1 [12.5], SRP 64.9 [18.5], SRR 39.1 [17.1] and CSP 27.6 [6.8]). No statistically differences were observed between the SAPM and SRP, SRR toothpastes (paired t-Test; ≤0.05) although a significant difference was noted between the SAPM and the CSP toothpastes. There was an overall trend for reduction for the SAPM compared to the SRR toothpaste. Conclusion:The results would suggest that a novel self-assembling peptide matrix gel (SAPM) was effective in blocking the dentine tubules and may therefore have the potential to be an effective desensitizing product for the treatment of Dentine Hypersensitivity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An In Vitro Comparison of A Novel Self-Assembling Peptide Matrix Gel and Selected Desensitizing Toothpastes in Reducing Fluid Flow by Dentine Tubular Occlusion

2020

J Dent Maxillofacial Res

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“…The 45S5 bioactive glass composition in the SRP formulation was originally designed as a bone substitute and not as an additive in toothpastes for treating DH. It has been postulated that the glass particles dissolve in the mouth releasing Ca 2+ and PO 4 3ions forming a hydroxycarbonated apatite (HCA) on the tooth surface and as such may not be acid resistant for permanent tubuli occlusion [1]. The main mode of action of strontium acetate (and strontium chloride) (SRR) for treatment of DH, has been suggested to be by tubular occlusion although the actual effect attributed to strontium in clinical studies has yet to be defined [28].…”

Section: Permeability Measurement (Hydraulic Conductance [Lp])mentioning

confidence: 99%

“…According to Hill and Gillam[1] despite the vast array of commercial products designed either as professionally applied products or techniques (Dentist applied) or as over-the counter products (OTC)(Home use) there is no universally accepted product that can completely resolve DH. The desensitising technologies evaluated in the current in vitro study included a novel self-assembling peptide matrix (SAPM) gel and three selected desensitizing toothpastes with established tubular occluding properties namely 1) a technology consisting of arginine, a naturally occurring amino acid, and an insoluble calcium compound, in the form of calcium carbonate (CSP), 2) a 45S5 bioactive glass formulation (SRP) and 3) a strontium acetate formulation (SRR).…”

mentioning

confidence: 99%

An in vitro comparison of a novel Self-Assembling Peptide Matrix Gel and selected desensitizing toothpastes in reducing fluid flow by dentine tubular occlusion

Hill¹,

Chen²,

Lysek³

et al. 2019

Preprint

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Background: The objective of the present in vitro study was to evaluate the ability of a novel self-assembling peptide matrix gel with calcium phosphate in effectively occluding dentine tubules compared to selected desensitizing toothpastes. Methods: Mid-coronal dentine discs with a thickness of 1 mm were sectioned from caries-free human molars. The discs were etched with 6% citric acid for 2 minutes, halved and subjected to a 2-minute brushing with a novel gel (SAPM) and three selected desensitizing toothpastes ([SRP], [SRR] and [CSP]). The ability of the desensitizing gel and toothpastes to occlude the dentine tubules was assessed and compared before and after brushing using Scanning Electron Microscopy (SEM) on both etched and fractured dentine surfaces. The SEM observations were supplemented by hydraulic conductance measurements using a modified Pashley model before and after tooth brushing (n=5). Results: The results demonstrated that there was a reduction in both the number and the diameter of the open dentine tubules, which was evident for all the treated dentine discs. The particles that occluded the open dentine tubules, however had different morphologies and distribution. The self-assembling peptide matrix gel (SAPM) demonstrated the greater reduction in the number of open tubules compared to the other desensitizing toothpastes. Reductions in the hydraulic conductance measurements were observed for all tested materials (mean [SD, %]: SAPM 55.1 [12.5], SRP 64.9 [18.5], SRR 39.1 [17.1] and CSP 27.6 [6.8]). No statistically differences were observed between the SAPM and SRP, SRR toothpastes (paired t-Test; ≤0.05) although a significant difference was noted between the SAPM and the CSP toothpastes. There was an overall trend for reduction for the SAPM compared to the SRR toothpaste. Conclusion: The results would suggest that a novel self-assembling peptide matrix gel (SAPM) was effective in blocking the dentine tubules and may therefore have the potential to be an effective desensitizing product for the treatment of Dentine Hypersensitivity.

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