Dentinogenic Ghost Cell Tumor of the Peripheral Variant Mimicking Epulis

Kumar, Uddipan; Vij, Hitesh; Vij, Ruchieka; Kharbanda, Jitin; Aparna, IN; Radhakrishnan, Raghu

doi:10.1155/2010/519494

Cited by 31 publications

(24 citation statements)

References 24 publications

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“…blastoma (CAA) and the unusual features can be The nuclei of these columnar cells remain in opposite described as atypical histomorphology for the time direction of basement membrane; a characteristic being. feature referred as reverse nuclear polarity [15][16]. The Postoperative observation over three month multilayered basal cells observed in this case might be period showed no evidence of recurrence and thus expressed as "irregular epithelial stratification".…”

Section: Introductionmentioning

confidence: 88%

Acanthomatous ameloblastoma in a female Spitz dog with rare atypical histomorphology: A case study

Das¹,

Nath²,

Alim³

et al. 2013

Vet World

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A 6 year old female Spitz dog was admitted to Teaching Veterinary Hospital at Chittagong Veterinary and Animal Sciences University with the history of inappetance and asymmetric lower jaw. Oral inspection revealed a pair of pale enlarged lobulated mass around the third molar tooth of the left mandible. The dog was clinically diagnosed with epulis and successfully cured by surgical excision. Histopathological section of the excised masses revealed characteristic features of acanthomatous ameloblastoma with some atypical lesions. Multifocal areas of ameloblastic islands were found in the dense sheet of proliferating epithelial layer protruding towards the sub epithelial connective tissue stroma. These islands were characterized with irregular epithelial stratification at the basal layer. Besides, presence of ghost cells was the unusual findings for such case. Prominent intercellular bridging and nuclear polymorphism in odontogenic cells were other decisive characters of the lesion. Based on the histomorphological appearance, the gingival tumor was designated as canine acanthomatous ameloblastoma (CAA) with atypical histomorphology.

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Section: Introductionmentioning

confidence: 88%

Acanthomatous ameloblastoma in a female Spitz dog with rare atypical histomorphology: A case study

Das¹,

Nath²,

Alim³

et al. 2013

Vet World

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“…3). 81 DGCT is sometimes accompanied by COC, and the DGCT dentinoid materials are eosinophilic, amorphous, and sometimes undergo transformation into osteodentin 82. Furthermore, dendritic cells representing Langerhans cells and melanocytes often infiltrate into tumoral epithelium 83…”

Section: Dentinogenic Ghost Cell Tumormentioning

confidence: 99%

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Lee

Kim

2014

Korean J Pathol

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Calcifying epithelial odontogenic tumors (CEOTs) and ghost cell odontogenic tumors (GCOTs) are characteristic odontogenic origin epithelial tumors which produce calcifying materials from transformed epithelial tumor cells. CEOT is a benign odontogenic tumor composed of polygonal epithelial tumor cells that show retrogressive calcific changes, amyloid-like deposition, and clear cytoplasm. Differentially, GCOTs are a group of transient tumors characterized by ghost cell presence, which comprise calcifying cystic odontogenic tumor (CCOT), dentinogenic ghost cell tumor (DGCT), and ghost cell odontogenic carcinoma (GCOC), all derived from calcifying odontogenic cysts (COCs). There is considerable confusion about COCs and GCOTs terminology, but these lesions can be classified as COCs or GCOTs, based on their cystic or tumorous natures, respectively. GCOTs include ameloblastomatous tumors derived from dominant odontogenic cysts classified as CCOTs, ghost cell-rich tumors producing dentinoid materials as DGCTs, and the GCOT malignant counterpart, GCOCs. Many authors have reported CEOTs and GCOTs variably express keratins, β-catenin, BCL-2, BSP, RANKL, OPG, Notch1, Jagged1, TGF-β, SMADs, and other proteins. However, these heterogeneous lesions should be differentially diagnosed to allow for accurate tumor progression and prognosis prediction.

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“…In addition, typically, the clinical preoperative diagnosis was suggestive of a reactive or inflammatory lesion (peripheral giant cell granuloma, pyogenic granuloma, epulis, or irritation fibroma). The clinical appearance of all of these lesions is similar; 24,25 therefore; this emphasized the importance of both histological and immunohistochemical examination in the biological aspect of DGCTs.…”

Section: Fi Gu Re 2c: Tumoral Lesion Formed By Acanthomatous Stellatementioning

confidence: 82%

Peripheral Dentinogenic Ghost Cell Tumor: Evaluation of Clinical, Histopathologic and Radiological Findings: Case Report

Pekiner¹,

Sener²,

Gümrü³

et al. 2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T The dentinogenic ghost cell tumor is a rare solid variant of the calcifying odontogenic cyst. A 77-year-old man presented with a gingival mass on the alveolar crest mucosa of canine to first premolar of the right mandibular region. After clinical and radiological examination, the prediagnosis was peripheral ossifying fibroma. An incisional biopsy was performed, and the specimen was submitted for histopathologic evaluation. The lesion was characterized histopatholocially by ameloblastoma-like odontogenic epithelial proliferation, presence of ghost cells and dentinoid material. It was finally diagnosed as peripheral dentinogenic ghost cell tumor after excision with a margin of sound bone. In this report, a rare new case is described and the relevant literature is briefly reviewed.K Ke ey y W Wo or rd ds s: : Odontogenic tumors; odontogenic cyst, calcifying; tomography Ö ÖZ ZE ET T Dentinojenik hayalet hücreli tümör, kalsifiye odontojenik kistin nadir bir solid varyantıdır. Yetmiş yedi yaşında erkek hasta, sağ mandibular bölgede birinci premoların yanındaki köpek dişinin alveol kret mukozası üzerinde gingival bir kitle ile başvurdu. Klinik ve radyolojik muayeneye göre başlangıçta periferal ossifiye fibrom tanısı konuldu. İnsizyonel biyopsi yapılarak, alınan örnek histopatolojik değerlendirmeye gönderildi. Lezyonun, histopatolojik olarak artış gösteren ameloblastik hücrelere benzer odontojenik hücreler, hayalet hücreler ve dentinoid materyal içerdiği gözlendi. Histopatolojik olarak periferal dentinojenik hayalet hücreli tümör tanısından sonra lezyon cerrahi olarak eksize edildi. Bu yazıda nadir olarak izlenen dentinojenik hayalet hücreli tümör olgusu tanımlandı ve konuyla ilgili literatür kısaca gözden geçirildi.

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Dentinogenic Ghost Cell Tumor of the Peripheral Variant Mimicking Epulis

Cited by 31 publications

References 24 publications

Acanthomatous ameloblastoma in a female Spitz dog with rare atypical histomorphology: A case study

Acanthomatous ameloblastoma in a female Spitz dog with rare atypical histomorphology: A case study

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Peripheral Dentinogenic Ghost Cell Tumor: Evaluation of Clinical, Histopathologic and Radiological Findings: Case Report

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