Deoxynivalenol exposure during pregnancy has adverse effects on placental structure and immunity in mice model

Toutounchi, Negisa Seyed; Braber, Saskia; Land, Belinda van‘t; Thijssen, Suzan; Garssen, Johan; Folkerts, Gert; Hogenkamp, Astrid

doi:10.1016/j.reprotox.2022.07.002

Cited by 6 publications

(3 citation statements)

References 84 publications

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“…DON passes through the fetus and causes abnormalities [23][24][25]. DON exposure during pregnancy alters the mRNA and protein expression of junctional proteins in the placenta [44]. The embryotoxic and teratogenic effects of T2-toxin and its metabolite, HT2-toxin, are not negligible, as they can cause miscarriage in several mammalian species.…”

Section: Discussionmentioning

confidence: 99%

First Results on the Presence of Mycotoxins in the Liver of Pregnant Fallow Deer (Dama dama) Hinds and Fetuses

Lakatos,

Babarczi,

Molnár

et al. 2024

Animals

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Reproductive abnormalities have been observed in fallow deer populations in Hungary. We supposed mycotoxin contamination to be one of the possible causes because multi-mycotoxin contamination is known to be dangerous even at low toxin levels, especially for young animals. We investigated the spatial pattern of mycotoxin occurrences and the relationship between maternal and fetal mycotoxin levels. A total of 72 fallow deer embryos and their mothers were sampled in seven forested regions in Hungary in the 2020/2021 hunting season. We analyzed Aflatoxin (AF), Zearalenone (ZEA), Fumonizin B1 (FB1), DON, and T2-toxin concentrations in maternal and fetal livers by ELISA. AF was present in 70% and 82%, ZEA in 41% and 96%, DON in 90% and 98%, T2-toxin in 96% and 85%, and FB1 in 84% and 3% of hind and fetus livers, respectively. All mycotoxins passed into the fetus, but only Fumonizin B1 rarely passed. The individual variability of mycotoxin levels was extremely high, but the spatial differences were moderate. We could not prove a relation between the maternal and fetal mycotoxin concentrations, but we found an accumulation of ZEA and DON in the fetuses. These results reflect the possible threats of mycotoxins to the population dynamics and reproduction of wild fallow deer.

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Section: Discussionmentioning

confidence: 99%

First Results on the Presence of Mycotoxins in the Liver of Pregnant Fallow Deer (Dama dama) Hinds and Fetuses

Lakatos,

Babarczi,

Molnár

et al. 2024

Animals

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“…These metabolites are synthetized by some Fusarium species, including F. graminearum , F. culmorum , and F. oxysporum . Studies have shown that biological activities of trichothecenes are attributed from their reactivity thereby elicits cytotoxicity as well as immune disruption (Toutounchi et al., 2022). As expected, the strain used for Quorn protein production (i.e., F. venenatum NRRL strain 26139) as well as Quorn meat products (e.g., Quorn mince and Quorn quarter pounders) were tested negative for trichothecenes: scirpentriol, 15‐acetoxyscirpenol, diacetoxyscirpenon, and 4‐monoacetoxyscirpenol (O'Donnell et al., 1998).…”

Section: Health‐promoting Effects Of Mycoproteins: Strains Characteri...mentioning

confidence: 99%

Mycoproteins and their health‐promoting properties: Fusarium species and beyond

Lee,

Pan,

Kim

et al. 2024

Comp Rev Food Sci Food Safe

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Filamentous fungal mycoproteins have gained increasing attention as sustainable alternatives to animal and plant‐based proteins. This comprehensive review summarizes the nutritional characteristics, toxicological aspects, and health‐promoting effects of mycoproteins, focusing on those derived from filamentous fungi, notably Fusarium venenatum. Mycoproteins are characterized by their high protein content, and they have a superior essential amino acid profile compared to soybeans indicating excellent protein quality and benefits for human nutrition. Additionally, mycoproteins offer enhanced digestibility, further highlighting their suitability as a protein source. Furthermore, mycoproteins are rich in dietary fibers, which have been associated with health benefits, including protection against metabolic diseases. Moreover, their fatty acids profile, with significant proportions of polyunsaturated fatty acids and absence of cholesterol, distinguishes them from animal‐derived proteins. In conclusion, the future of mycoproteins as a health‐promoting protein alternative and the development of functional foods relies on several key aspects. These include improving the acceptance of mycoproteins, conducting further research into their mechanisms of action, addressing consumer preferences and perceptions, and ensuring safety and regulatory compliance. To fully unlock the potential of mycoproteins and meet the evolving needs of a health‐conscious society, continuous interdisciplinary research, collaboration among stakeholders, and proactive engagement with consumers will be vital.

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“…Deoxynivalenol (DON) is a mycotoxin mainly produced by Fusarium [5]. DON can cause emesis and loss of appetite when ingested by animals [6], whereas the long-term ingestion of DON causes animals to experience chronic intestinal bowel diseases, immune inhibition, susceptibility to infections, and reduced growth performance and reproductive performance [7,8]. Because of its toxicity and ubiquity, DON is considered a serious concern for food and feed security [9].…”

Section: Introductionmentioning

confidence: 99%

A NADPH-Dependent Aldo/Keto Reductase Is Responsible for Detoxifying 3-Keto-Deoxynivalenol to 3-epi-Deoxynivalenol in Pelagibacterium halotolerans ANSP101

Liu,

Ma,

Tang

et al. 2024

Foods

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Deoxynivalenol (DON), primarily generated by Fusarium species, often exists in agricultural products. It can be transformed to 3-epi-deoxynivalenol (3-epi-DON), with a relatively low toxicity, via two steps. DDH in Pelagibacterium halotolerans ANSP101 was proved to convert DON to 3-keto-deoxynivalenol (3-keto-DON). In the present research, AKR4, a NADPH-dependent aldo/keto reductase from P. halotolerans ANSP101, was identified to be capable of converting 3-keto-DON into 3-epi-DON. Our results demonstrated that AKR4 is clearly a NADPH-dependent enzyme, for its utilization of NADPH is higher than that of NADH. AKR4 functions at a range of pH 5–10 and temperatures of 20–60 °C. AKR4 is able to degrade 89% of 3-keto-DON in 90 min at pH 7 and 50 °C with NADPH as the cofactor. The discovery of AKR4, serving as an enzyme involved in the final step in DON degradation, might provide an option for the final detoxification of DON in food and feed.

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Deoxynivalenol exposure during pregnancy has adverse effects on placental structure and immunity in mice model

Cited by 6 publications

References 84 publications

First Results on the Presence of Mycotoxins in the Liver of Pregnant Fallow Deer (Dama dama) Hinds and Fetuses

First Results on the Presence of Mycotoxins in the Liver of Pregnant Fallow Deer (Dama dama) Hinds and Fetuses

Mycoproteins and their health‐promoting properties: Fusarium species and beyond

A NADPH-Dependent Aldo/Keto Reductase Is Responsible for Detoxifying 3-Keto-Deoxynivalenol to 3-epi-Deoxynivalenol in Pelagibacterium halotolerans ANSP101

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