Deoxyribonuclease activities in human leukemic cells and mouse lymphoblasts

Zöllner, E. Jürgen; Beck, Jörn-D.; Lemmel, E. -M.; Ζahn, Rudolf K.

doi:10.1016/s0304-3835(75)95898-x

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1992

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Cited by 9 publications

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“…The activity of one of the two acid DNases in PHA-stimulated lymphocytes increases parallel to the [3H]thymidine incorporation [9], Com pared to the corresponding non-m alignant and non-proliferating cells, the activity o f one of the two acid DNases is enhanced in hum an leu kemic cells and mouse lymphoblasts (L 5 1 7 8 Y cells) [10]. In the mouse the activity of acid spleen DNase increases in comparison to proliferation of cells after antigen injections [11].…”

Section: Introductionmentioning

confidence: 99%

Acid Dnase Activities In Peripheral, Mononuclear Blood Cells: A Possible Parameter To Detect Proliferating Cell Populations

Reitz

Gutjahr²

1992

Zeitschrift Für Naturforschung C

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Section: Introductionmentioning

confidence: 99%

Acid Dnase Activities In Peripheral, Mononuclear Blood Cells: A Possible Parameter To Detect Proliferating Cell Populations

Reitz

Gutjahr²

1992

Zeitschrift Für Naturforschung C

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DNase II-Aktivierung in der Rattenleber nach Akuter Sch�digung durch Di�thylnitrosamin

Schmerold

Tempel

1981

Arch Toxicol

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Single oral treatment of rats with acutely toxic doses of diethylnitrosamine (DENA) caused a temporary increase of liver-deoxyribonuclease II (DNase II) in homogenate, parenchymal cell, and diverse cell compartments. Highest stimulation resulted in nuclear fraction and cytosol. Due to largely congruent in vitro features, it was suggested that the normal as well as the DENA-activated DNase II were identical. Non-ionic detergents enhanced the enzyme activity only in control samples to a relatively small extent. Suitable conditions of reaction provided, the activation was suppressed by cycloheximide. The results indicated different mechanisms of DNase II activation in the course of an acute DENA-intoxication: 1. release of structurally bound DNase II fractions into cytosol; 2. induction of the enzyme and/or of an effector; 3. enhancement of the nucleus bound enzyme activity by translocation of activated DNase II from cytosolic to nuclear area.

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