“…Quinazolinones are a well-known family of N -heterocyclic compounds with bioactivities [ 1 , 2 , 3 , 4 , 5 , 6 ] on multiple fronts and occur often in natural products [ 7 , 8 , 9 , 10 ]. Recently, a group of special tricyclic quinazoline alkaloids, such as 2,3-dihydropyrrolo[2,1- b ]quinazolin-9(1 H )-ones, have attracted increased attention from medicinal chemists and biologists for their bioactivity levels in areas such as antitumor, antibacterial, anti-inflammatory and anti-acetylcholinesterase activities [ 11 , 12 , 13 , 14 , 15 , 16 ]. Key examples include deoxyvasicinone and vasicinone isolated from the adhatoda vasica medicinal plant, with pronounced anti-inflammatory, antimicrobial, and antidepressant activities ( Figure 1 ) [ 17 , 18 , 19 , 20 ].…”