DEPArray™ single-cell technology: A validation study for forensic applications

Schulte, Janine; Caliebe, Amke; Marciano, Michael; Neuschwander, Pia; Seiberle, Ilona; Scheurer, Eva; Schulz, Iris

doi:10.1016/j.fsigen.2024.103026

Forensic Science International: Genetics

2024

DOI: 10.1016/j.fsigen.2024.103026

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DEPArray™ single-cell technology: A validation study for forensic applications

Janine Schulte,

Amke Caliebe,

Michael Marciano

et al.

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Characterizing stutter in single cells and the impact on multi-cell analysis

Vandepoele,

Novotna,

Myers

et al. 2025

Forensic Science International: Genetics

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Characterizing stutter in single cells and the impact on multi-cell analysis

Vandepoele,

Novotna,

Myers

et al. 2025

Forensic Science International: Genetics

View full text Add to dashboard Cite

Genomic Multicopy Loci Targeted by Current Forensic Quantitative PCR Assays

Jäger

2024

Genes

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Modern forensic DNA quantitation assays provide information on the suitability of a DNA extract for a particular type of analysis, on the amount of sample to put into the analysis in order to yield an optimal (or best possible) result, and on the requirement for optional steps to improve the analysis. To achieve a high sensitivity and specificity, these assays are based on quantitative PCR (qPCR) and analyze target DNA loci that are present in multiple copies distributed across the genome. These target loci allow the determination of the amount of DNA, the degree of DNA degradation, and the proportion of DNA from male contributors. In addition, internal control DNA of a known amount is analyzed in order to inform about the presence of PCR inhibitors. These assays are nowadays provided as commercial kits that have been technically validated and are compatible with common qPCR instruments. In this review, the principles of forensic qPCR assays will be explained, followed by information on the nature of DNA loci targeted by modern forensic qPCR assays. Finally, we critically draw attention to the current trend of manufacturers not to disclose the exact nature of the target loci of their commercial kits.

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DEPArray™ single-cell technology: A validation study for forensic applications

Cited by 2 publications

References 44 publications

Characterizing stutter in single cells and the impact on multi-cell analysis

Characterizing stutter in single cells and the impact on multi-cell analysis

Genomic Multicopy Loci Targeted by Current Forensic Quantitative PCR Assays

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