2008
DOI: 10.1371/journal.pcbi.1000242
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Dependence of Bacterial Chemotaxis on Gradient Shape and Adaptation Rate

Abstract: Simulation of cellular behavior on multiple scales requires models that are sufficiently detailed to capture central intracellular processes but at the same time enable the simulation of entire cell populations in a computationally cheap way. In this paper we present RapidCell, a hybrid model of chemotactic Escherichia coli that combines the Monod-Wyman-Changeux signal processing by mixed chemoreceptor clusters, the adaptation dynamics described by ordinary differential equations, and a detailed model of cell … Show more

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Cited by 113 publications
(165 citation statements)
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“…However, noise also leads to cell-to-cell variability, affecting populations of cells. For instance, there is large variation in adaptation times probably due to low copy numbers of CheR and CheB [28,53]. In addition, different adapted CheY-p levels have been observed in cells of the same population [54].…”
Section: Cell-to-cell Variability and Cell Behaviormentioning
confidence: 99%
“…However, noise also leads to cell-to-cell variability, affecting populations of cells. For instance, there is large variation in adaptation times probably due to low copy numbers of CheR and CheB [28,53]. In addition, different adapted CheY-p levels have been observed in cells of the same population [54].…”
Section: Cell-to-cell Variability and Cell Behaviormentioning
confidence: 99%
“…The steepness of the gradients that can be sensed is thus determined by the swimming how these properties combine as a control strategy for migrating cell populations, as highlighted by a series of theoretical studies [34][35][36][37][38][39][40][41]. Following a decade of relative silence after the earlier theoretical work [34,35], recent years have seen a spur of papers addressing questions of how intracellular signaling can affect the behavior of migrating cells and populations [34][35][36][37][38][39][40][41].…”
Section: Strategies For Bacterial Chemotaxismentioning
confidence: 99%
“…Bacteria require a certain amount of time to chemotax a significant distance. 34 However, this is in direct conflict with the operation of a flow-based microfluidic gradient generator, where the gradient steepness deteriorates with time. Bacteria in flow, experience a changing gradient as they move down the channel length.…”
Section: Additional Considerations In Using Flow-based Gradient Gmentioning
confidence: 99%
“…34 While this model only demonstrates simulated outcomes in a static environment with a stable gradient, it can be used to approximate the time limits of an observable chemotactic response. Additionally, the response to aspartate can be considered as representative of chemotaxis in general, since it is a well-documented chemoattractant for E. coli and generates a strong chemotactic response.…”
Section: -7mentioning
confidence: 99%
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