1997
DOI: 10.1039/a701491k
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Dependence of hydrolytic cleavage of histidine-containing peptides by palladium(II) aqua complexes on the co-ordination modes of the peptides

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Cited by 71 publications
(31 citation statements)
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“…In the reaction with peptides containing C-terminal histidine, as in MeCO-Gly-His, cis-[Pd(H 2 O) 2 (en)] 2 does not effect hydrolysis. This regioselective cleavage of the amide bond involving the carboxylic group of histidine was also observed in the reactions of cis-[Pd(H 2 O) 2 (L-HMet-S,N)] 2 complexes with MeCO-His-Gly [9].…”
Section: Introductionsupporting
confidence: 58%
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“…In the reaction with peptides containing C-terminal histidine, as in MeCO-Gly-His, cis-[Pd(H 2 O) 2 (en)] 2 does not effect hydrolysis. This regioselective cleavage of the amide bond involving the carboxylic group of histidine was also observed in the reactions of cis-[Pd(H 2 O) 2 (L-HMet-S,N)] 2 complexes with MeCO-His-Gly [9].…”
Section: Introductionsupporting
confidence: 58%
“…Previous studies with Gly-His and cis-[PdCl 2 (en)] or cis-[PdCl 2 (L-HMet-S,N)] have shown that 1 was also a major product in these reactions [9±11]. The complex crystallized from the reaction between K 2 PdCl 4 or cis-[PdCl 2 (en)] and Gly-His at pH < 3 [9,11]. In this study, the palladium(II) chloro complexes cis-[PdCl 2 (en)] and cis-[PdCl 2 (L-HMet-S,N)] were treated with Ala-His and Ser-His to explore the coordination modes of peptides with a free terminal amino group.…”
Section: Resultsmentioning
confidence: 96%
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“…This difference can be attributed to the fact that higher H + concentration favors the release of en ligand by protonation of its amino groups [41]. Furthermore, it is obvious that the increase of Cl ) accelerates the detachment of en ligand from Au(III) ion (Table 3).…”
Section: −1mentioning
confidence: 99%
“…3) [26] in combination with computer simulations (Chem3D Ultra 7.0). Both peak broadening and downfield shifts were observed for the imidazole H-atoms, the methine H-atoms adjacent to the amino group of HisLeu, and the imidazole and methine H-atoms adjacent to the amino group of hist, when the Ni II /hist/HisLeu ratio was set to 1 : 100 : 100.…”
mentioning
confidence: 99%