Dependence of rat hippocampal c-Fos expression on intensity and duration of exercise

Lee, Taeck Hyun; Jang, Mi Hyeon; Shin, Min Chul; Lim, Baek Vin; Kim, Young Pyo; Kim, Hong; Choi, Hyun-Soo; Lee, Kwang-Sik; Kim, Ee Hwa; Kim, Sang Hoon

doi:10.1016/s0024-3205(02)02406-2

Cited by 53 publications

(40 citation statements)

References 46 publications

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“…One possibility, for example, is that there is an exercise-induced upregulation of proteasome activity, as reported previously in muscle (Radak et al, 2000), that can mediate the degradation of the proteolytic fragments of APP (Nunan et al, 2001(Nunan et al, , 2003Lopez Salon et al, 2003;Schmitz et al, 2004). A more likely scenario, however, is that exercise is modulating APP metabolism directly (for review, see Turner et al, 2003) by increases in neuronal activity (Lee et al, 2003). For example, APP processing can be augmented by PKC, MAPK (mitogen-activated protein kinase), and phospholipase C (for review, see Turner et al, 2003), and these pathways are known to be activated by exercise (Shen et al, 2001;Molteni et al, 2002;our unpublished observations).…”

Section: Discussionmentioning

confidence: 86%

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

Adlard¹,

Perreau²,

Pop³

et al. 2005

J. Neurosci.

701

454

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which there are few therapeutics that affect the underlying disease mechanism. Recent epidemiological studies, however, suggest that lifestyle changes may slow the onset/progression of AD. Here we have used TgCRND8 mice to examine directly the interaction between exercise and the AD cascade. Five months of voluntary exercise resulted in a decrease in extracellular amyloid-␤ (A␤) plaques in the frontal cortex (38%; p ϭ 0.018), the cortex at the level of the hippocampus (53%; p ϭ 0.0003), and the hippocampus (40%; p ϭ 0.06). This was associated with decreased cortical A␤1-40 (35%; p ϭ 0.005) and A␤1-42 (22%; p ϭ 0.04) (ELISA). The mechanism appears to be mediated by a change in the processing of the amyloid precursor protein (APP) after short-term exercise, because 1 month of activity decreased the proteolytic fragments of APP [for ␣-Cterminal fragment (␣-CTF), 54% and p ϭ 0.04; for ␤-CTF, 35% and p ϭ 0.03]. This effect was independent of mRNA/protein changes in neprilysin and insulin-degrading enzyme and, instead, may involve neuronal metabolism changes that are known to affect APP processing and to be regulated by exercise. Long-term exercise also enhanced the rate of learning of TgCRND8 animals in the Morris water maze, with significant ( p Ͻ 0.02) reductions in escape latencies over the first 3 (of 6) trial days. In support of existing epidemiological studies, this investigation demonstrates that exercise is a simple behavioral intervention sufficient to inhibit the normal progression of AD-like neuropathology in the TgCRND8 mouse model.

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Section: Discussionmentioning

confidence: 86%

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

Adlard¹,

Perreau²,

Pop³

et al. 2005

J. Neurosci.

701

454

View full text Add to dashboard Cite

show abstract

“…These results indicate that the Chinese campus is an important brain region for behavioral control, learning and memory and one of the major target regions for the aftermath effects of heavy exercise-induced fatigue [7][8][9] . The number of Fos-immunoreactive neurons in the hippocampus is found to correlate with the duration and intensity of exercise [6] . Thus, expression of c-fos mRNA and Fos-immunoreactive neurons in the brain, notably in the hippocampus, is a good marker of the state of fatigue in the central nervous system [5][6][7] .…”

Section: Introductionmentioning

confidence: 95%

“…The number of Fos-immunoreactive neurons in the hippocampus is found to correlate with the duration and intensity of exercise [6] . Thus, expression of c-fos mRNA and Fos-immunoreactive neurons in the brain, notably in the hippocampus, is a good marker of the state of fatigue in the central nervous system [5][6][7] .…”

Section: Introductionmentioning

confidence: 95%

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Effects of Traditional Chinese Medicine Radix Astragali, Fructus Aurantii and Rhizoma Cypei Extracts on c-Fos Expression in the Aging Rat Hippocampus Induced by Exercise

et al. 2004

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Fatigue is a complex interaction between the peripheral systems and the central nervous system and is often a problem in aging individuals. In accordance with the view of traditional Chinese medicine, treatment of fatigue, as induced by heavy exercise, is related to the restoration of Qi in the body. In order to investigate the effects of two formulations of traditional Chinese medicine, namely the Qi-supplementing (QS) medicine containing radix astragaliand the QS formulation plus Qi-rectifying (QR) medicine containing radix astragali, fructus aurantii and rhizoma cypei, which are often used in elderly individuals, aging rats which were exercised for 5 weeks were treated with the above two formulations. Immunocytochemistry revealed that the number of Fos-immunoreactive neurons in the CA1 and CA2 regions of the hippocampus was significantly increased after heavy exercise. Treatment with the QS + QR formulation but not the QS formulation was able to downregulate the number of Fos-immunoreactive neurons in the CA1 and CA2 regions of the hippocampus to the levels of the nonexercise controls. These results indicate that the Chinese medicine formulations, notably the QS + QR formulation, are effective in the restoration of normal levels of Fos protein expression in the central nervous system after heavy exercise. These results have important implications in the treatment of fatigue in aging individuals using formulations of traditional Chinese medicine.

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“…Foi observado que ocorre um aumento na atividade metabólica no hipocampo de ratos submetidos a protocolos de exercício, ocorrendo aumento na utilização de glicose pelo encéfalo em diversas regiões, sendo que no hipocampo este aumento foi de 29% (Vissing et al, 1996). A ativação neuronal foi observada também através de marcação para c-Fos (marcador de atividade neuronal) onde observou-se que exercícios de maior intensidade promovem maior atividade neuronal; porém, em um protocolo de exercício leve, a expressão de c-Fos aumentou apenas até o 7º dia de corrida, decaindo subsequentemente (Lee et al, 2003).…”

Section: Ativação Neuronal E O Fluxo Sanguíneo Cerebral (Fsc)unclassified

Neuroplasticidade induzida pelo exercício: efeitos sobre o hipocampo e regiões motoras do encéfalo de ratos.

Ferreira¹

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Dependence of rat hippocampal c-Fos expression on intensity and duration of exercise

Cited by 53 publications

References 46 publications

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

Effects of Traditional Chinese Medicine Radix Astragali, Fructus Aurantii and Rhizoma Cypei Extracts on c-Fos Expression in the Aging Rat Hippocampus Induced by Exercise

Neuroplasticidade induzida pelo exercício: efeitos sobre o hipocampo e regiões motoras do encéfalo de ratos.

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