“…To achieve an optimal primary stability, a compromise should be found between: 1. reducing the relative micro-motions at the bone-implant interface (BII), 2. avoiding large gaps between bone and implant, which may lead to the formation of fibrous tissue in the peri-implant region [5], the formation of low-quality bone tissue or even inhibit bone growth [22,32,41], and 3. avoiding excessive stresses in peri-implant bone tissue, which may lead to bone necrosis or local ischemia [45]. All these phenomena may jeopardize osseointegration processes [22,38,42], and can lead to implant loosening. It remains difficult to predict ACI loosening because of its multi-factorial causes related to the implant properties, the cavity geometry (e.g., its diameter), and to the patient's bone quality [1,18,26].…”