Dependence of the Raman spectra of drug substances upon laser excitation wavelength

Thorley, Fiona C.; Baldwin, Kurt J.; Lee, Dong Hoon; Batchelder, D. N.

doi:10.1002/jrs.1446

Cited by 27 publications

(17 citation statements)

References 7 publications

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“…244 nm) is also effective in avoiding fluorescence as it is well separated from the Raman signal. [6] It has been demonstrated that conventional dispersive Raman spectroscopy, with far-red excitation, of N-methyl-3, 4-methylenedioxyamphetamine (MDMA) and related compounds can be very rapid and effective. This type of fluorescence can be avoided if the Raman signal is located in a different region (e.g.…”

Section: Bulk Street Drugsmentioning

confidence: 99%

Detection of drugs of abuse by Raman spectroscopy

West

Went

2010

Drug Testing and Analysis

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Raman spectroscopy can provide rapid, sensitive, non-destructive analysis of a variety of drug types (e.g. amphetamines, alkaloids, designer drugs, and date rape drugs). This review concentrates on developments in the past 15 years. It considers identification and quantification of drugs of abuse in different types of forensic evidence, including bulk street drugs as well as traces found in drinks, on fibres/clothing, in fingerprints, on fingernails, on bank notes, and in body fluids.

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Section: Bulk Street Drugsmentioning

confidence: 99%

Detection of drugs of abuse by Raman spectroscopy

West

Went

2010

Drug Testing and Analysis

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“…This shift provides information about vibrational, rotational and other low frequency transitions in molecules. Raman spectroscopy can be used to study solid, liquid and gaseous samples [2][3][4][5]. A Raman system typically consists of four major components: Excitation source (Laser), Sample illumination system and light collection optics, Wavelength selector (Filter or Spectrophotometer) and Detector (Photodiode array, CCD or PMT).…”

Section: Raman Spectroscopy and Comsol Multiphysics Overviewmentioning

confidence: 99%

Characterization and Experimental Investigation of Tin Micro Tubular Coil Heater Using Raman Spectroscopy

Sureshkannan¹,

Kumar²,

Saravanan³

2013

Archives of Metallurgy and Materials

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Raman spectroscopy is a commonly used tool in bio-diagnostics and micro sensor technology. Surface-enhanced Raman scattering provides high signal enhancements especially at micro and nanostructured metallic surfaces. Micro tubular coil heaters have been widely investigated because of their extensive applications in PET Preformed Moulds, Hot Runner Nozzles & Bushings and Thin Walled Container Moulds and other Microsystems. This paper describes the characterization, experimental investigation and analysis of Titanium Nitride (TiN) micro tubular coil heater using Raman spectroscopy and Comsol multiphysics. The material characterization was performed using Raman spectrometer and the geometric optimization for the micro tubular coil heater was performed by simulating a wide range of possible geometries using COMSOLTM, a commercial Finite Element Analysis (FEA) package. The characteristic dimensions of the microstructures are varied and the results are discussed and compared to each other. The simulated results of micro tubular heaters having an improved temperature distribution over the sensing area and a higher density of integration is presented in this paper.

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“…The final drug concentration was about 10 −6 mol l −1 . A detailed assignment of all vibrational modes suggested the preponderance of the polymorphic form I of paracetamol [23,24]. It is well known that there are two major possibilities of molecular adsorption on the metal surface, namely, physisorption and chemisorption.…”

Section: Sers Of Antipyretics and Analgesicsmentioning

confidence: 99%

SERS and Pharmaceuticals

Pinzaru¹,

Pavel²

2010

Surface Enhanced Raman Spectroscopy

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IntroductionDevelopments in the pharmaceutical industry are nowadays driven by the requirement for high efficacy while retaining reduced side effects. For this reason, new medicines are very often of relatively low dose, typically less than 100 mg of drug substance (i.e. less than 10% w/w) in a tablet. This poses major analytical challenges with respect to the rapid chemical identification of active drug substances, their polymorphic forms, possible contaminants, the distribution and interaction between drug substances and excipients, and so on. Drug and excipient particle sizes can vary, but they are generally of micron size, thus resulting in dosage samples that have substance inhomogeneity on a similar scale. Therefore, the analysis of such dosage samples by conventional techniques such as mass spectrometry, elemental analysis, spectrophotometry or nuclear magnetic resonance (NMR) can be very difficult.With the advent of new instrumentation and intense monochromatic light sources, Raman spectroscopy has become a popular tool for analysing pharmaceutical compounds [1, 2]. However, a major problem with the analysis of pharmaceutical compounds by Raman spectroscopy is the weak intensity of the Raman scattered signal and the fluorescence caused by either the active drug itself or by a small amount of impurity present in the sample. The fluorescence emission of aromatic molecules generally occurs in the near-UV to visible spectral region. Therefore, it can interfere with the Raman signal if it is located within that spectral region. This problem can be circumvented if Raman scattering is excited in the UV or near-infrared (NIR) region of the electromagnetic spectrum, by choosing a laser of appropriate wavelength (e.g. a UV or NIR laser). Moreover, the NIR laser photon does not have enough energy to excite the fluorophore by single-photon excitation. This results in a reduced fluorescence emission. On the other hand, excitation with a UV laser still produces fluorescence, but the Raman spectrum is positioned in the relatively fluorescence-free UV region of the electromagnetic spectrum [3]. However, there are two major disadvantages associated with NIR excitation. The Raman intensity is inversely proportional to the fourth power of

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Dependence of the Raman spectra of drug substances upon laser excitation wavelength

Cited by 27 publications

References 7 publications

Detection of drugs of abuse by Raman spectroscopy

Detection of drugs of abuse by Raman spectroscopy

Characterization and Experimental Investigation of Tin Micro Tubular Coil Heater Using Raman Spectroscopy

SERS and Pharmaceuticals

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