Dependence of the viscoelastic response of the urinary bladder wall on strain rate

Mastrigt, Ron van; Nagtegaal, J. C.

doi:10.1007/bf02442547

Cited by 23 publications

(15 citation statements)

References 4 publications

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“…We also conclude that the relaxation increases with increasing infusion rates. This is in accordance with former studies on bladder strips in vitro [4], However, with bladder distension to moderate volumes the in fluence of infusion rate and increasing transmural pres sure on relative bladder relaxation seems to be small. The explanation for this effect is probably the complex nature of the bladder wall, with extensive increase in elasticity only at large distension [6].…”

Section: Discussionsupporting

confidence: 80%

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Bladder Wall Relaxation and Its Dependency on Transmural Pressure and Infusion Rate during Cystometry - in vivo Studies in the Rat

Andersson

Bjerle²,

Kronström³

1988

Urol Int

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Cystometry at different infusion rates was performed in 7 rats in vivo. The bladders were furthermore allowed to relax from different transmural pressures. When distension of the bladder was moderate, relative relaxation was small and almost independent of transmural pressure and infusion rate. When distended to large volumes, however, there was a marked increase in bladder wall relaxation and the relaxation increased with increasing infusion rates. These findings indicate the importance of standardization of the cystometric procedure.

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Section: Discussionsupporting

confidence: 80%

“…Stress relaxation of bladder wall strips has theoretically and experimen tally shown to be dependent on the strain rate [4]. Stress relaxation of the human bladder has been studied by rapid cystometry up to a fixed intravesical pressure [5].…”

Section: Introductionmentioning

confidence: 99%

Bladder Wall Relaxation and Its Dependency on Transmural Pressure and Infusion Rate during Cystometry - in vivo Studies in the Rat

Andersson

Bjerle²,

Kronström³

1988

Urol Int

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“…Most experiments on the bladder tissue under simple and complex loading protocols have been conducted on animals and only a few studies have been dedicated to the investigation of the human organ per se (Alexander 1971(Alexander , 1976Kondo et al 1972;Coolsaet et al 1975aCoolsaet et al , b, 1976van Mastright et al 1978;van Mastrigt and Nagtegaal 1981;Andersson et al 1989;Venegas et al 1991;Wagg and Fry 1999;Finkbeiner 1999;Sacks 2000;Gloeckner et al 2002;Gloeckner 2003;Korossis et al 2009;Nagatomi et al 2008;Parekh et al 2010;Wognum 2010). Linear strips for uniaxial stretching were usually collected from different regions of the organ.…”

Section: Biomechanics Of the Detrusormentioning

confidence: 99%

Biomechanics of the Human Urinary Bladder

Miftahof¹,

Nam²

2013

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“…The resulting experimental data were then fitted using lumped-parameter models (Kondo et al 1972;Coolsaet et al 1975aCoolsaet et al ,b, 1976van Mastrigt and Nagtegaal 1981;Andersson et al 1989;Venegas et al 1991;Wagg and Fry 1999). Although these previous studies provided important insights into the viscoelastic properties of the UBW, there continue to be limitations.…”

Section: Introductionmentioning

confidence: 98%

“…During the past several decades researchers primarily focused on investigating the viscoelasticity of the bladder using both uniaxially loaded tissue strips in vitro (Coolsaet et al 1975a(Coolsaet et al ,b, 1976van Mastrigt and Nagtegaal 1981;Wagg and Fry 1999) and whole organ cystometry in vivo (Kondo et al 1972;Coolsaet et al 1975a,b;Andersson et al 1989;Venegas et al 1991). The resulting experimental data were then fitted using lumped-parameter models (Kondo et al 1972;Coolsaet et al 1975aCoolsaet et al ,b, 1976van Mastrigt and Nagtegaal 1981;Andersson et al 1989;Venegas et al 1991;Wagg and Fry 1999).…”

Section: Introductionmentioning

confidence: 99%

Contribution of the extracellular matrix to the viscoelastic behavior of the urinary bladder wall

Nagatomi

Toosi

Chancellor

et al. 2007

Biomech Model Mechanobiol

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We previously reported that when the stress relaxation response of urinary bladder wall (UBW) tissue was analyzed using a single continuous reduced relaxation function (RRF), we observed non-uniformly distributed, time-dependent residuals (Ann Biomed Eng 32(10):1409-1419, 2004). We concluded that the single relaxation spectrum was inadequate and that a new viscoelastic model for bladder wall was necessary. In the present study, we report a new approach composed of independent RRFs for smooth muscle and the extracellular matrix components (ECM), connected through a stress-dependent recruitment function. In order to determine the RRF for the ECM component, biaxial stress relaxation experiments were first performed on decellularized extracellular matrix network of the bladder obtained from normal and spinal cord injured rats. While it was assumed that smooth muscle followed a single spectrum RRF, modeling the UBW ECM required a dual-Gaussian spectrum. Experimental results revealed that the ECM stress relaxation response was insensitive to the initial stress level. Thus, the average ECM RRF parameters were determined by fitting the average stress relaxation data. The resulting stress relaxation behavior of whole bladder tissue was modeled by combining the ECM RRF with the RRF for the smooth muscle component using an exponential recruitment function representing the recruitment of collagen fibers at higher stress levels. In summary, the present study demonstrated, for the first time, that stress relaxation response of bladder tissue can be better modeled when divided into the contributions of the extracellular matrix and smooth muscle components. This modeling approach is suitable for prediction of mechanical behaviors of the urinary bladder and other organs that exhibit rapid tissue remodeling (i.e., smooth muscle hypertrophy and altered ECM synthesis) under various pathological conditions.

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Dependence of the viscoelastic response of the urinary bladder wall on strain rate

Cited by 23 publications

References 4 publications

Bladder Wall Relaxation and Its Dependency on Transmural Pressure and Infusion Rate during Cystometry - in vivo Studies in the Rat

Bladder Wall Relaxation and Its Dependency on Transmural Pressure and Infusion Rate during Cystometry - in vivo Studies in the Rat

Biomechanics of the Human Urinary Bladder

Contribution of the extracellular matrix to the viscoelastic behavior of the urinary bladder wall

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