Dependence of ultrasound decorrelation on urine scatter particle concentration for a non-invasive diagnosis of bladder outlet obstruction

Arif, Muhammad; Idzenga, Tim; Korte, Chris L. de; Mastrigt, Ron van

doi:10.1002/nau.22666

Cited by 5 publications

(3 citation statements)

References 15 publications

(28 reference statements)

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“…First, the use of contrast agents was inevitable in this study because the bladder of the participants was emptied before imaging to measure the residual urine volume as a routine examination, and the retrograde injection of saline with acoustic scatterers was necessary to ensure successful imaging. Physiological urine (especially the morning condensed urine) may contain some crystals that can serve as acoustic scatterers 6 . Thus, future studies should investigate the applicability of the CE‐UroVPI technique during physiological urinary voiding.…”

Section: Discussionmentioning

confidence: 99%

“…Physiological urine (especially the morning condensed urine) may contain some crystals that can serve as acoustic scatterers. 6 Thus, future studies should investigate the applicability of the CE-UroVPI technique during physiological urinary voiding. Second, the duration of imaging acquisition was restricted to 3 s in this study due to a hardware limitation, and it was insufficient to observe an episode of voiding phases.…”

Section: Discussionmentioning

confidence: 99%

“…3 Therefore, it is crucial to provide timeresolved observation of the urinary tract deformation during the initiation and terminal phases of voiding and its interaction with the urinary flow since major voiding symptoms (delayed, weak, intermittent, and dribbling micturition) are associated with such dynamic phases. Precise measurements of such urinary flow properties have been attempted using color Doppler imaging, 4,5 ultrasound turbulence index imaging, 6 and computational fluid dynamics (CFD) 7,8 ; however, none of these methods have visualized time-resolved and quantitative urinary flow dynamics during the voiding phase. Additionally, the flow direction in the urethra is non-uniform because of the curved structure of the male urethra.…”

Section: Introductionmentioning

confidence: 99%

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Transrectal ultrasound vector projectile imaging for time‐resolved visualization of flow dynamics in the male urethra: A clinical pilot study

Ishii,

Yamanishi,

Kamasako

et al. 2023

Medical Physics

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BackgroundQuantitative and comprehensive visualization of urinary flow dynamics in the urethra is crucial for investigating patient‐specific mechanisms of lower urinary tract symptoms (LUTS). Although some methods can evaluate the global properties of the urethra, it is critical to assess the local information, such as the location of the responsible lesion and its interactions with urinary flow in relation to LUTS. This approach is vital for enhancing personalized and focal treatments. However, there is a lack of such diagnostic tools that can directly observe how the urethral shape and motion impact urinary flow in the urethra.PurposeThis study aimed to develop a novel transrectal ultrasound imaging modality based on the contrast‐enhanced urodynamic vector projectile imaging (CE‐UroVPI) framework and validate its clinical applicability for visualizing time‐resolved flow dynamics in the urethra.MethodsA new CE‐UroVPI system was developed using a research‐purpose ultrasound platform and a custom transrectal linear probe, and an imaging protocol for acquiring urodynamic echo data in male patients was designed. Thirty‐four male patients with LUTS participated in this study. CE‐UroVPI was performed to acquire ultrasound echo signals from the participant's urethra and urinary flow at various voiding phases (initiation, maintenance, and terminal). The ultrasound datasets were processed with custom software to visualize urinary flow dynamics and urethra tissue deformation.ResultsThe transrectal CE‐UroVPI system successfully visualized the time‐resolved multidirectional urinary flow dynamics in the prostatic urethra during the initiation, maintenance, and terminal phases of voiding in 17 patients at a frame rate of 1250 fps. The maximum flow speed measured in this study was 2.5 m/s. In addition, when the urethra had an obstruction or an irregular partial deformation, the devised imaging modality visualized complex flow patterns, such as vortices and flow jets around the lesion.ConclusionsOur study findings demonstrate that the transrectal CE‐UroVPI system developed in this study can effectively image fluid‐structural interactions in the urethra. This new diagnostic technology has the potential to facilitate quantitative and precise assessments of urethral voiding functions and aid in the improvement of focal and effective treatments for patients with LUTS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%