Dependence of yield strain of human trabecular bone on anatomic site

Morgan, Elise F.; Keaveny, Tony M.

doi:10.1016/s0021-9290(01)00011-2

Cited by 591 publications

(447 citation statements)

References 35 publications

Supporting

Mentioning

401

Contrasting

Unclassified

Order By: Relevance

“…[31][32][33][34] The bone specimens were secured to the endcaps using a fast curing methyl methacrylate-based resin embedding media (Technovit 1 3040, Kulzer, Wehrheim, Germany). The resulting gage length was $10 mm.…”

Section: Mechanical Testingmentioning

confidence: 99%

“…Because there was no initial nonlinear region in the stress-strain curves, elastic modulus values were calculated from a best-fit straight line to the stress-strain data in the 0-0.2% strain range, as previously recommended. [31][32][33][34] All mechanical tests were performed on a moving-magnet linear motor materials testing system (ELF 3300 Bose-Enduratec, Eden Prairie, MN), with a 2.25 kN load cell, and a displacement transducer (12.7 mm, accuracy 2 mm). Cores were kept hydrated during testing.…”

Section: Mechanical Testingmentioning

confidence: 99%

See 1 more Smart Citation

Effects of preexisting microdamage, collagen cross‐links, degree of mineralization, age, and architecture on compressive mechanical properties of elderly human vertebral trabecular bone

Follet

Viguet-Carrin

Burt‐Pichat

et al. 2010

Journal Orthopaedic Research

View full text Add to dashboard Cite

Previous studies have shown that the mechanical properties of trabecular bone are determined by bone volume fraction (BV/ TV) and microarchitecture. The purpose of this study was to explore other possible determinants of the mechanical properties of vertebral trabecular bone, namely collagen cross-link content, microdamage, and mineralization. Trabecular bone cores were collected from human L2 vertebrae (n ¼ 49) from recently deceased donors 54-95 years of age (21 men and 27 women). Two trabecular cores were obtained from each vertebra, one for preexisting microdamage and mineralization measurements, and one for BV/TV and quasi-static compression tests. Collagen cross-link content (PYD, DPD, and PEN) was measured on surrounding trabecular bone. Advancing age was associated with impaired mechanical properties, and with increased microdamage, even after adjustment by BV/TV. BV/TV was the strongest determinant of elastic modulus and ultimate strength (r 2 ¼ 0.44 and 0.55, respectively). Microdamage, mineralization parameters, and collagen cross-link content were not associated with mechanical properties. These data indicate that the compressive strength of human vertebral trabecular bone is primarily determined by the amount of trabecular bone, and notably unaffected by normal variation in other factors, such as crosslink profile, microdamage and mineralization. Keywords: bone strength; microdamage; microarchitecture; mineralization; collagen cross-links; vertebral trabecular bone Several studies have shown that the mechanical properties of trabecular bone are influenced by bone volume fraction (BV/TV) and microarchitecture. 1,2 However, additional factors, such as degree of mineralization, preexisting microdamage, and collagen cross-link profile may also play a role, yet the contribution of these factors to human trabecular bone mechanical properties remains incompletely understood.Increased mineralization of cortical bone is exponentially related to increased stiffness, but decreased energy absorption. 3 A similar trend was seen in human trabecular bone from the calcaneus, with a positive relationship between mineralization and elastic modulus, after adjusting for BV/TV. 4 It has also been suggested that a reduction in the heterogeneity of mineralization density distribution leads to increased bone fragility, 5 but there are few data to support this assertion.Microdamage has been largely studied in animal models and in human cortical bone, with only a few studies reporting microdamage in human trabecular bone either naturally occurring 6-11 or due to loading ex-vivo. 12 In cortical bone, microdamage accumulation leads to decreased mechanical properties, 13,14 and therefore has been implicated in skeletal fragility and stress fractures. 15 However, the association between microdamage and cortical bone fracture toughness was weak, 16 raising questions as to the role of microdamage in cortical bone. Increased microdamage has also been associated with decreased strength in human vertebral cancellous bone; 1...

show abstract

Section: Mechanical Testingmentioning

confidence: 99%

Section: Mechanical Testingmentioning

confidence: 99%

Effects of preexisting microdamage, collagen cross‐links, degree of mineralization, age, and architecture on compressive mechanical properties of elderly human vertebral trabecular bone

Follet

Viguet-Carrin

Burt‐Pichat

et al. 2010

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…Therefore, to calibrate Hounsfield Units to apparent density, the average Hounsfield Units from the dense cancellous column within the femoral head, the cancellous bone in the greater trochanter, and the cortical diaphysis of each bone were assumed to have average apparent densities in those locations. 13,14 From these calibration points, we calculated a single regression curve of apparent density as a function of Hounsfield Units (S- Fig. 2).…”

Section: Fe Modelsmentioning

confidence: 99%

Hip resurfacing increases bone strains associated with short‐term femoral neck fracture

Long

Santner

Bartel

2009

Journal Orthopaedic Research

View full text Add to dashboard Cite

Short-term femoral neck fracture is a primary complication associated with contemporary hip resurfacing. Some fractures are associated with neck notching, while others occur in the absence of notching. These unexplained fractures may be due to large magnitude strains near the implant rim, which could cause bone damage accumulation and eventual neck fracture. We used statistically augmented finite element analysis to identify design and environmental variables that increase bone strains near the implant rim after resurfacing, and lead to strain magnitudes sufficient for rapid damage accumulation. After resurfacing, the compressive strains in the inferior, peripheral neck increased by approximately 25%, particularly when the implant shell was bonded. While the tensile strains in the peripheral neck were low in magnitude in the immediate postoperative models, they increased substantially following compressive damage accumulation. Low bone modulus, within the range of normal bone, and high head load contributed the most to large magnitude strains. Therefore, in some cases, hip resurfacing may cause a region of compressive bone damage to develop rapidly, which in turn leads to large tensile strains and potential neck fracture. Our study suggests that indications for surgery should account for bone material quality, and that rehabilitation protocols should avoid high-load activities. ß

show abstract

“…To characterise the mechanical properties of trabecular bone previous studies have primarily relied on uniaxial compression testing of representative samples of trabecular bone (Goldstein 1987;Røhl et al 1991;Kopperdahl and Keaveny 1998;Morgan and Keaveny 2001;Keaveny et al 1993;Keyak et al 1996). Few studies have performed confined compression testing Linde and Hvid 1989;Charlebois et al 2010a) or multiaxial compression testing (Fenech and Keaveny 1999;Keaveny et al 1999;Rincon-Kohli and Zysset 2009) although trabecular bone is naturally constrained in vivo by the surrounding 6 cortex.…”

Section: Introductionmentioning

confidence: 99%

An experimental and computational investigation of the post-yield behaviour of trabecular bone during vertebral device subsidence

Kelly

Harrison

McDonnell

et al. 2012

Biomech Model Mechanobiol

View full text Add to dashboard Cite

PublisherSpringer-Verlag AbstractInterbody fusion device subsidence has been reported clinically. An enhanced understanding of the mechanical behaviour of the surrounding bone would allow for accurate predictions of vertebral subsidence. The multiaxial inelastic behaviour of trabecular bone is investigated at a microscale and macroscale level. The post-yield behaviour of trabecular bone under hydrostatic and confined compression is investigated using micro-computed tomography derived microstructural models, elucidating a mechanism of pressure dependent yielding at the macroscopic level. Specifically, microstructural trabecular simulations predict a distinctive yield point in the apparent stress-strain curve under uniaxial, confined and hydrostatic compression. Such distinctive apparent stress-strain behaviour results from localised stress concentrations and material yielding in the trabecular microstructure. This phenomenon is shown to be independent of the plasticity formulation employed at a trabecular level. The distinctive response can be accurately captured by a continuum model using a crushable foam plasticity formulation in which pressure dependent yielding occurs.Vertebral device subsidence experiments are also performed, providing measurements of the trabecular plastic zone. It is demonstrated that a pressure dependent plasticity formulation must be used for continuum level macroscale models of trabecular bone in order to replicate the experimental observations, further supporting the microscale investigations. Using a crushable foam plasticity formulation in the simulation of vertebral subsidence, it is shown that the predicted subsidence force and plastic zone size correspond closely with the experimental measurements. In contrast the use of von Mises, Drucker-Prager and Hill plasticity formulations for continuum trabecular bone models lead to over prediction of the subsidence force and plastic zone.

show abstract

Dependence of yield strain of human trabecular bone on anatomic site

Cited by 591 publications

References 35 publications

Effects of preexisting microdamage, collagen cross‐links, degree of mineralization, age, and architecture on compressive mechanical properties of elderly human vertebral trabecular bone

Effects of preexisting microdamage, collagen cross‐links, degree of mineralization, age, and architecture on compressive mechanical properties of elderly human vertebral trabecular bone

Hip resurfacing increases bone strains associated with short‐term femoral neck fracture

An experimental and computational investigation of the post-yield behaviour of trabecular bone during vertebral device subsidence

Contact Info

Product

Resources

About