Dependence on age of methamphetamine-produced changes in thermoregulation and metabolism

Cj, Estler

doi:10.1007/bf01923231

Cited by 7 publications

(6 citation statements)

References 10 publications

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“…As a psychomotor stimulant, METH causes increased activation of and metabolism in the CNS and skeletal muscles (Estler, 1975; Makisumi et al, 1998), which may elevate brain and body temperature. In addition, METH causes vasoconstriction (Gordon et al, 1991; Turnipseed et al, 2003; Watts & McCollester, 2006; Haning & Goebert, 2007), which can contribute to the ensuing hyperthermia by preventing heat dissipation in the periphery.…”

Section: Meth and Temperature Regulationmentioning

confidence: 99%

Methamphetamine-induced toxicity: An updated review on issues related to hyperthermia

Matsumoto

Seminerio

Turner

et al. 2014

Pharmacology & Therapeutics

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Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine.

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Section: Meth and Temperature Regulationmentioning

confidence: 99%

Methamphetamine-induced toxicity: An updated review on issues related to hyperthermia

Matsumoto

Seminerio

Turner

et al. 2014

Pharmacology & Therapeutics

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“…For example, amphetamine-like psychomotor stimulant drugs (i.e., amphetamine, methamphetamine or METH, MDMA or Ecstasy) induce behavioral and sympathetic activation, increase brain metabolism (73, 74) and elevate temperatures (75–79). These drugs also have peripheral vasoconstrictive effects (80, 81), thus diminishing heat dissipation to the external environment.…”

Section: Pathological Brain Hyperthermia Induced By Psychomotor Stmentioning

confidence: 99%

Brain temperature homeostasis: physiological fluctuations and pathological shifts

Kiyatkin¹

2010

Front Biosci

178

203

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The goal of this work is to discuss brain temperature as a physiological parameter, which reflects the balance between metabolism-related intra-brain heat production and heat loss by cerebral circulation to the rest of the body and then to the external environment. First, we present data on fluctuations in brain temperature occurring under physiological and behavioral conditions and discuss their mechanisms. Since most processes governing neural activity are temperature-dependent, we consider how naturally occurring temperature fluctuations could affect neural activity and neural functions. Then, we review brain temperature changes induced by psychomotor stimulants and show that the hyperthermic effects of these drugs are state-dependent and modulated by environmental conditions. Since high temperature could irreversibly damage neural cells and dramatically worsen various pathological processes, we consider the situations associated with pathological brain hyperthermia and evaluate its role in acute perturbations of brain functions, neurotoxicity, and neurodegeneration. We also discuss the complexities and limitations in consideration of brain temperature within the frameworks of physiological regulation and homeostasis. While different adaptive mechanisms could, within some limits, compensate for an altered heat balance of the brain, real life often creates situations when this balance could not be compensated, resulting in pathology and life-threatening health complications.

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“…However, METH also induces metabolic activation [5,6]. Enhanced metabolism is tightly related to oxidative stress, which is caused by an imbalance between the production of reactive oxygen and a biological system’s ability to detoxify readily the reactive intermediates or easily repair the resulting damage.…”

Section: Introductionmentioning

confidence: 99%

Breakdown of Blood-Brain and Blood-Spinal Cord Barriers During Acute Methamphetamine Intoxication: Role of Brain Temperature

Kiyatkin

Sharma²

2016

CNSNDDT

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Methamphetamine (METH) is a powerful and often abused stimulant with potent addictive and neurotoxic properties. While it is generally believed that structural brain damage induced by METH results from oxidative stress, in this work we present data suggesting robust disruption of blood-brain and blood-spinal cord barriers (BBB and BSCB) during acute METH intoxication in rats. We demonstrate the relationships between METH-induced brain hyperthermia and widespread but structure-specific barrier leakage, acute glial activation, changes in brain water and ionic homeostasis, and structural damage of different types of cells in the brain and spinal cord. Therefore, METH-induced leakage of the BBB and BSCB is a significant contributor to different types of functional and structural brain abnormalities that determine acute toxicity of this drug and possibly neurotoxicity during its chronic use.

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Dependence on age of methamphetamine-produced changes in thermoregulation and metabolism

Abstract: In contrast to juvenile mice, old mice treated with methamphetamine are unable to adequately mobilize their carbohydrate reserves. They cannot increase their overall metabolism and become hypothermic, while juvenile mice react with increased calorigenesis and hyperthermia.

Cited by 7 publications

References 10 publications

Methamphetamine-induced toxicity: An updated review on issues related to hyperthermia

Methamphetamine-induced toxicity: An updated review on issues related to hyperthermia

Brain temperature homeostasis: physiological fluctuations and pathological shifts

Breakdown of Blood-Brain and Blood-Spinal Cord Barriers During Acute Methamphetamine Intoxication: Role of Brain Temperature

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