Background:A study estimated the biopsychosocial factors related to active physical behavior in the Brazilian population with and without chronic non-transmissible disease (CNCD).Methodology: Cross-sectional study of the National Health Survey (NHS) in Brazil, with 60,202 individuals. The outcome was physically active behavior. The independent variables were social characteristics, lifestyle and health. Cox regression was applied to estimate the prevalence ratio (PR).Results: 29,666 (48.3%; 95% CI: 47.0–50.0) reported having CNCD. Not being a smoker or alcoholic, living in an urban area, having informal social support, you are in class A, high schooling as well as paid work are more associated with active lifestyle in both groups. However, in the group without CNCD, the female sex, having some disability and not having private health insurance were more associated with sedentary behavior, while in the group with CNCD, being elderly, white and not having restful sleep are associated with sedentary lifestyle.Conclusion: People with and without CNCD in Brazil have very close active behavior, however, some biopsychosocial factors such as: sex, age, lifestyle, socioeconomic level are unevenly associated with the active lifestyle in the groups. Thus, therapeutic or preventive proposals as well as public policies for health promotion must observe these distinctions when elaborating their actions.