Depending on different apoptosis pathways, the effector Cscaspase-3 in Chilo suppressalis exposed to temperature and parasitic stress was induced

Dong, Chuan-Lei; Zhu, Fei; Du, Yu‐Zhou; Lu, Ming‐Xing

doi:10.1016/j.ijbiomac.2023.124270

Cited by 2 publications

(1 citation statement)

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“…In aquatic animals, temperature affects the function of the neuroendocrine function system, which further reduces immunity and alters their metabolism [9]. Moreover, low temperature induces apoptosis [10,11]; however, the potential toxic effect of low temperature on crustacean apoptosis and hematopoiesis is unclear.…”

Section: Introductionmentioning

confidence: 99%

Regulation Mechanism of Dopamine Receptor 1 in Low Temperature Response of Marsupenaeus japonicus

Ren,

Bian,

Shao

et al. 2023

IJMS

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Dopamine receptors (DARs) are important transmembrane receptors responsible for receiving extracellular signals in the DAR-mediated signaling pathway, and are involved in a variety of physiological functions. Herein, the D1 DAR gene from Marsupenaeus japonicus (MjDAD1) was identified and characterized. The protein encoded by MjDAD1 has the typical structure and functional domains of the G-protein coupled receptor family. MjDAD1 expression was significantly upregulated in the gills and hepatopancreas after low temperature stress. Moreover, double-stranded RNA-mediated silencing of MjDAD1 significantly changed the levels of protein kinases (PKA and PKC), second messengers (cyclic AMP (cAMP), cyclic cGMP, calmodulin, and diacyl glycerol), and G-protein effectors (adenylate cyclase and phospholipase C). Furthermore, MjDAD1 silencing increased the apoptosis rate of gill and hepatopancreas cells. Thus, following binding to their specific receptors, G-protein effectors are activated by MjDAD1, leading to DAD1-cAMP/PKA pathway-mediated regulation of caspase-dependent mitochondrial apoptosis. We suggest that MjDAD1 is indispensable for the environmental adaptation of M. japonicus.

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Section: Introductionmentioning

confidence: 99%