Depicting Fecal Microbiota Characteristic in Yak, Cattle, Yak-Cattle Hybrid and Tibetan Sheep in Different Eco-Regions of Qinghai-Tibetan Plateau

Wang, Xiaoqi; Zhang, Zhichao; Li, Biao; Hao, Wenjing; Yin, Weiwen; Ai, Sitong; Han, Jing; Wang, Rujing; Duan, Ziyuan

doi:10.1128/spectrum.00021-22

Cited by 15 publications

(7 citation statements)

References 52 publications

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“…Additionally, ruminants rely on microbial production of acetate and β-Hydroxybutyrate, which are key precursors for C4-C16 lipids in their milk ( Fidan and Zhan, 2019 ). Gut microbiota diversity of free-range yaks (at 4000 m-5000 m) has been found to be significantly higher compared to captive yaks (around 3000 m), thereby providing further substantiation for our hypothesis ( Wang et al, 2022 ). These differences in composition, nutrition, and function of ghee lipids at different altitudes lay the foundation for precision processing and the development of nutritional products containing functional lipids derived from ghee.…”

Section: Discussionsupporting

confidence: 73%

Characterization of lipid composition and nutritional quality of yak ghee at different altitudes: A quantitative lipidomic analysis

Yang,

Wen,

Xie

et al. 2024

Food Chemistry: X

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Section: Discussionsupporting

confidence: 73%

Characterization of lipid composition and nutritional quality of yak ghee at different altitudes: A quantitative lipidomic analysis

Yang,

Wen,

Xie

et al. 2024

Food Chemistry: X

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“…Among the ASVs, the p-251-o5 family, identi ed in M1, was described in the fecal microbiota of pigs [123] and in the rumen of ewes and cows [124,125]. In addition, the [Eubacterium] coprostanoligenes group, an anaerobic bacteria potentially impacting host lipid metabolism [126], had lower abundances in Tibetan sheep infected with gastrointestinal nematodes [127], corroborating our results and suggesting that it could be a promising target for H. contortus resistance. Christensenellaceae R-7, a hub feature in M2, was associated with amino acid and lipid metabolism and with human metabolic health in different disease contexts, including obesity and in ammatory bowel disease [128].…”

Section: Discussionmentioning

confidence: 99%

Multi-omics elucidated parasite-host-microbiota interactions and resistance to Haemonchus contortus in sheep

Niciura,

Cardoso,

Ibelli

et al. 2023

Preprint

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Background: The integration of molecular data from hosts, parasites, and microbiota can enhance our understanding of the complex biological interactions underlying parasite resistance. Haemonchus contortus, the predominant sheep parasite species in the tropics, results in significant production and economic losses, which are further compounded by the diminishing efficiency of chemical control measures due to anthelmintic resistance. Knowledge of how the host responds to infection and how the parasite, in combination with microbiota effects, modulates host immunity can guide selection decisions to breed more resistant animals. This understanding can also refine management practices and inform the development of new therapeutics for long-term helminth control. Results: Egg per gram (EPG) counts were obtained in Morada Nova sheep subjected to two artificial infections with H. contortus, and used as a proxy to select animals with high resistance or susceptibility. The GAST, GNLY, IL13, MGRN1, FGF14, and RORC genes and transcripts were differentially expressed between groups based on RNA-seq of the abomasum. From 50K SNP genotyping, EPG heritability estimate was 0.12, and a genome-wide association study (GWAS) identified regions on chromosomes 2 and 11 harboring candidate genes for resistance, immune response, body weight, and adaptation. Trans-eQTLs between significant variants and differentially expressed transcripts were found. Amplicon sequence variants (ASVs) from PCR amplification and sequencing of bacterial and archaeal 16S rRNA genes in sheep feces and rumen generated functional co-expression modules correlated with resistance to H. contortus, showing enrichment in pathways of response to bacterium, immune and inflammatory responses, and hub features of the Christensenellaceae, Bacteroides, and Methanobrevibacter genera, Prevotellaceae family, and Verrucomicrobiota. In RNA-seq of H. contortus, some mitochondrial, collagen- and cuticle-related genes were expressed only in parasites retrieved from susceptible sheep. Conclusions: This study identified chromosome regions, genes, transcripts, and pathways involved in the elaborate interactions between the sheep host, its gastrointestinal microbiota and the H. contortus parasite. These findings can assist with the development of animal selection strategies for parasite resistance and interdisciplinary approaches to control H. contortus in sheep.

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“…During the long evolutionary process, yak rumen microorganisms have gradually developed an adaptive mechanism by altering the composition according to the fluctuating pasture availability. During the summer, when pasture is abundant, the ability of yak rumen microbes to obtain energy from the diet increases substantially, which promotes compensatory growth in the renourishment process [19]. Conversely, during the cold season, when forage is scarce, yak rumen microbes enhance the ability to digest and utilize low-quality forage, thereby mitigating the effects of the poor, fibrous forage [20].…”

Section: Microbial Mechanisms Of Yaks Coping With Pasture Scarcitymentioning

confidence: 99%

Yaks Are Dependent on Gut Microbiota for Survival in the Environment of the Qinghai Tibet Plateau

Wang,

Bai,

Huang

et al. 2024

Preprint

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The yak (Poephagus grunniens) has evolved unique adaptations to survive the harsh environment of the Tibetan Plateau, while their gut microorganisms play a crucial role in maintaining the health of the animal. Gut microbes spread through the animal population not only by horizontal transmission but also vertically, which enhances microbial stability and inheritance between generations of the population. Homogenization of gut microbes in different animal species occurs in the same habitat enhancing interspecies coexistence. Using the yak as a model animal, this paper reviews the adaptive strategies under extreme environments and how the gut microbes of the yak circulate throughout the Tibetan Plateau system, which not only affects other plateau animals such as plateau pikas, but can also have a profound impact on the health of people. By examining the relationships between yaks and their gut microbes, this review provides new perspectives in understanding the adaptations of plateau animals and the stability of the ecosystem.

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Depicting Fecal Microbiota Characteristic in Yak, Cattle, Yak-Cattle Hybrid and Tibetan Sheep in Different Eco-Regions of Qinghai-Tibetan Plateau

Cited by 15 publications

References 52 publications

Characterization of lipid composition and nutritional quality of yak ghee at different altitudes: A quantitative lipidomic analysis

Characterization of lipid composition and nutritional quality of yak ghee at different altitudes: A quantitative lipidomic analysis

Multi-omics elucidated parasite-host-microbiota interactions and resistance to Haemonchus contortus in sheep

Yaks Are Dependent on Gut Microbiota for Survival in the Environment of the Qinghai Tibet Plateau

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