Depicting People in Visual Cues Affects Alcohol Cue Reactivity in Male Alcohol-Dependent Patients

Alarefi, Abdulqawi; Wang, Xunshi; Tao, Rui; Rui, Qinqin; Gao, Geng; Wang, Ying; Pang, Liangjun; Qiu, Bensheng; Liu, Chialun; Zhang, Xiaochu

doi:10.3390/brainsci12030307

Cited by 4 publications

(1 citation statement)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adult research has systematically varied physical and social drinking context in laboratory cue‐reactivity paradigms (Nees et al, 2012) such as by comparing reactivity to images of people adults regularly smoke with versus not (Conklin et al, 2013) and evaluating cue reactivity to in vivo smoking cues when peers are present or not (Dimoff et al, 2019). Among adults, neurophysiological markers of craving also differ as a function of peer contexts in alcohol images (Alarefi et al, 2022; Martins et al, 2019; Nees et al, 2012; Schwabe & Wolf, 2013). Together, adult studies examining self‐report and physiological indicators of cue‐elicited craving suggest that substance‐using peers may serve as potent cues that elicit craving in youth.…”

Section: Introductionmentioning

confidence: 99%

Peer‐elicited alcohol craving in adolescents and emerging adults: Bridging the laboratory and natural environment

Meisel

Padovano

Pielech

et al. 2023

Alcohol: Clinical and Experimental Research

View full text Add to dashboard Cite

Background Although peers figure prominently in developmental models of alcohol use, our understanding of the influence of peer social context in cue reactivity paradigms with adolescents and emerging adults in the human laboratory and the natural environment is limited. This study tested associations between alcohol craving among youth in the human laboratory using alcohol‐related images, with and without peers, and in the natural environment using ecological momentary assessment (EMA). Methods Data for this preregistered secondary analysis were collected prior to randomization in two medication trials (N = 115). Participants completed an image cue exposure paradigm at the baseline laboratory session followed by approximately 7 days of EMA. Results In the laboratory, model‐based mean comparisons from multilevel models (MLMs) showed that all drinking images elicited greater craving than neutral images. No differences were observed across the three image categories containing alcohol. Image category by age interactions demonstrated that, compared to older youth, younger youth displayed lower craving in response to neutral versus social drinking context with peers images and older, compared to younger, youth displayed higher craving in response to nonsocial drinking images versus social drinking contexts with peers images. In the natural environment, craving was greatest when youth were in the presence of alcohol‐using peers and alcohol‐related cues, regardless of age. Laboratory craving to alcohol images was positively associated with craving in the natural environment. Conclusions For youth, peers are a salient social context associated with increased craving, particularly in the natural environment. Laboratory cue reactivity to alcohol images predicted real‐world craving, further supporting the ecological validity of this paradigm in youth.

show abstract

Section: Introductionmentioning

confidence: 99%

Peer‐elicited alcohol craving in adolescents and emerging adults: Bridging the laboratory and natural environment

Meisel

Padovano

Pielech

et al. 2023

Alcohol: Clinical and Experimental Research

View full text Add to dashboard Cite

show abstract

Alcohol dependence inpatients classification with GLM and hierarchical clustering integration using fMRI data of alcohol multiple scenario cues

et al. 2022

View full text Add to dashboard Cite

Effectiveness of Reducing Craving in Alcohol Use Disorder Using a Serious Game (SALIENCE): Randomized Controlled Trial

Weber,

Shevchenko,

Gerhardt

et al. 2023

JMIR Form Res

View full text Add to dashboard Cite

Background Alcohol use disorder (AUD) has become a major global health problem. Therapy for this condition is still a great challenge. Recently, it has become increasingly evident that computer-based training is a valuable addition to the treatment of addictive disorders. Objective This study aims to evaluate the web-based serious game SALIENCE (Stop Alcohol in Everyday Life-New Choices and Evaluations) as an add-on therapy for AUD. It combines the cue-exposure therapy approach with elements of decision-making training, enhanced by interactive panoramic images. The effects of SALIENCE training on levels of craving, attention, and cognitive bias are investigated. Methods In a randomized controlled trial, 62 participants with AUD undergoing 3 weeks of an extended alcohol detoxification program were randomly allocated to an intervention and a control group. A total of 49 individuals (mean age 44.04 y; 17/49, 35% female) completed all sessions and were included in the analysis. Only pretreatment data were available from the other 13 patients. Participants answered questionnaires related to alcohol consumption and craving and completed neuropsychological tasks at the beginning of the study and 2 weeks later to evaluate levels of attention and cognitive biases. During the 2-week period, 27 of the participants additionally performed the SALIENCE training for 30 minutes 3 times a week, for a total of 6 sessions. Results We observed a significant decrease in craving in both groups: the control group (mean 15.59, SD 8.02 on the first examination day vs mean 13.18, SD 8.38 on the second examination day) and the intervention group (mean 15.19, SD 6.71 on the first examination day vs mean 13.30, SD 8.47 on the second examination day; F1,47=4.31; P=.04), whereas the interaction effect was not statistically significant (F1,47=0.06; P=.80). Results of the multiple linear regression controlling for individual differences between participants indicated a significantly greater decrease in craving (β=4.12; t36=2.34; P=.03) with the SALIENCE intervention. Participants with lower drinking in negative situations reduced their craving (β=.38; t36=3.01; P=.005) more than people with higher drinking in negative situations. Conclusions The general effectiveness of SALIENCE training as an add-on therapy in reducing alcohol craving was not confirmed. Nevertheless, taking into account individual differences (gender, duration of dependence, stress, anxiety, and drinking behavior in different situations), it was shown that SALIENCE training resulted in a larger reduction in craving than without. Notably, individuals who rarely consume alcohol due to negative affect profited the most from SALIENCE training. In addition to the beneficial effect of SALIENCE training, these findings highlight the relevance of individualized therapy for AUD, adapted to personal circumstances such as drinking motivation. Trial Registration ClinicalTrials.gov NCT03765476; https://clinicaltrials.gov/show/NCT03765476

show abstract

Depicting People in Visual Cues Affects Alcohol Cue Reactivity in Male Alcohol-Dependent Patients

Cited by 4 publications

References 58 publications

Peer‐elicited alcohol craving in adolescents and emerging adults: Bridging the laboratory and natural environment

Peer‐elicited alcohol craving in adolescents and emerging adults: Bridging the laboratory and natural environment

Alcohol dependence inpatients classification with GLM and hierarchical clustering integration using fMRI data of alcohol multiple scenario cues

Effectiveness of Reducing Craving in Alcohol Use Disorder Using a Serious Game (SALIENCE): Randomized Controlled Trial

Contact Info

Product

Resources

About