Depilatory creams increase the number of hair follicles, and dermal fibroblasts expressing interleukin-6, tumor necrosis factor-α, and tumor necrosis factor-β in mouse skin

Tsai, Pi-Fen; Chou, Fen‐Pi; Yu, Ting-Shuan; Lee, Huei-Jane; Chiu, Chun-Tang

doi:10.4196/kjpp.2021.25.6.497

Cited by 10 publications

(5 citation statements)

References 23 publications

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“…They work by breaking down the sulphur bonds in the hair's keratin that are sensitive to strong alkaline and deoxidation agents. The active ingredient for deoxidizing the sulphur bonds is a salt of thioglycolic acid (Tsai et al, 2021). Chemical depilation generally does not destroy the dermal papilla, and hair is able to grow back afterwards, because relatively small amounts of chemicals are used (Pohl et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Untitled

2023

EJA

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Leflunomide is an antirheumatic drug commonly used by females, as this disease is common in females and there are chances of pregnancy while taking this medication in initial months of pregnancy this commonly prescribed drug lacks studies related to its teratogenic potential. Present study was conducted to know about its teratogenicity in mice embryos. Pregnant mice were exposed to Leflunomide by oral route on gestational days 6 to 11 either as single dose in one of the gestational days or continuous doses. The embryos were collected on day 19 of gestation, were measured and examined for external anomalies. Findings suggested that Leflunomide was embryo lethal when given as continuous dose as there were 100% resorption of embryos. In the single dose group, maximum resorptions were found when was given in early pregnancy. Other anomalies included malrotated limbs, open eyes, kinking of tails, defect in anterior abdominal wall and visceroptosis and anencephaly. these anomalies were noted in embryos exposed to leflunomide only on gestational days 7 and 8. The above findings suggest that leflunomide interferes with embryonic growth It also interferes with neural tube closure leading to anencephaly. Findings of open eyes and kinking tails suggest that the drug may affect epithelial and mesodermal growth. Leflunomide perhaps interferes with the lateral folding of the embryo leading to defect in the anterior abdominal wall and visceroptosis.The present study concludes that Leflunomide is teratogenic and embryolethal in mice and should be avoided in human pregnancy.

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Section: Discussionmentioning

confidence: 99%

Untitled

2023

EJA

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Section: Discussionmentioning

confidence: 99%

Lawsonia inermis and paraphenylenediamine exerts an insidious effect on the epidermal, renal, and hepatic tissue with repeated application: a histological and morphometrical study

Jen,

Adam,

Garba

et al. 2023

EJA

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Ground leaves of Lawsonia inermis (LI) made into a paste has been used from the Bronze Age as cosmetic application. Para-Phenylenediamine (PPD) is an organic compound that is added to LI to increase its aesthetic appearance and longevity. Addition of PPD increases the possibility of allergic contact dermatitis from LI tattoo combinations, and may be absorbed through the skin, affecting body organs. The current study was conducted to determine the effect of this mixture on the histology of skin, liver and kidney tissue. Thirty albino rats were grouped into five groups. The treatment protocol included a control group (I), application of LI paste alone for a period of two weeks (II), and four weeks (III), and a combination of LI and PPD for two weeks (IV), and four weeks (V). All rats in each group had an area on the lumbar region shaved and marked, and the paste was applied to this region. The rats were sacrificed after the experimental period and the tissues of interest removed for further histological and morphometric analysis. Application of LI alone caused no observable histological changes, however, in combination with PPD, LI caused thinning of the epidermis, reduction in the quantity of collagen fibers in the dermis, distorted the arrangement of hepatocytes, caused infiltration of inflammatory cells into the liver tissue and distortion in the arrangement of renal tubular epithelial cells. The longer the exposure to LI and PPD, the more alteration to the normal histology of tissues.

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“…The data suggested that sodium sulfide made a significant impact on healing, compared with depilatory cream and physical depilation methods. Furthermore, it has been reported recently that compared with shaving methods, commercially available depilatory creams caused a transient minor inflammatory response of the skin and increased the levels of cytokines that might subsequently affect hair growth but increased the number of hair follicles [ 40 ]. Coincidentally, this can also be observed in Figure 3 D in the present study.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Different Preoperative Depilation Ways on the Healing of Wounded Skin in Mice

Jia

Zhang

2022

Animals

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Hair removal is necessary before operating on animals with dense hair layers. To provide an appropriate hair removal method and maintain animal welfare, we introduced four commonly used depilation methods—namely, scissors shearing, electric shaving, depilatory cream, and sodium sulfide, and made systematic comparisons, instead of only examining one or two methods, as reported in the past. To further assess convenience and possible effects on skin wound healing, we performed a skin trauma model after depilation in C57BL/6J mice and recorded wound healing time. Meanwhile, the skin tissues around the wound were stained with H&E and Masson. The results showed that the wound contraction rate of the sodium sulfide group was significantly lower than other groups at different points in time. Furthermore, depilatory cream and sodium sulfide methods could induce a topical inflammatory response on the third day after the operation and delay the regeneration of collagen fibers. We concluded that sodium sulfide depilatory has a significant negative effect on wound healing. Depilatory cream is gentler, with mild skin irritation and symptoms of inflammation. The electric shaving method is more convenient and safer, and thus could be the best choice for preoperative depilation.

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Depilatory creams increase the number of hair follicles, and dermal fibroblasts expressing interleukin-6, tumor necrosis factor-α, and tumor necrosis factor-β in mouse skin

Cited by 10 publications

References 23 publications

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Lawsonia inermis and paraphenylenediamine exerts an insidious effect on the epidermal, renal, and hepatic tissue with repeated application: a histological and morphometrical study

The Effect of Different Preoperative Depilation Ways on the Healing of Wounded Skin in Mice

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