Dépistage néonatal ciblé de la drépanocytose : limites du test de falciformation (test d’Emmel) dans le bilan prénatal en zone ouest africaine

Diallo, Dapa A.; Guindo, Aldiouma; Touré, Boubacari Ali; Sarro, Yeya Sadio; Sima, Mamadou; Tessougué, O.; Baraïka, Mohamed Ag; Guindo, Pierre; Traoré, Mamadou; Diallo, Moussa; Dorie, A.

doi:10.1016/j.respe.2018.02.007

Cited by 14 publications

(15 citation statements)

References 15 publications

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“…In our study, the sex ratio (1.03), in favour of men, was similar to that reported in the literature [ 5 , 13 , 14 , 19 – 21 ]. The average weight of newborns with abnormal hemoglobins was comparable to observations made by Munyanganizi in Rwanda and Kafando in Burkina Faso [ 10 , 19 ].…”

Section: Discussionsupporting

confidence: 91%

“…A selective pressure with the evolution of the disease would have contributed to the increase in its prevalence. Results found in the literature indicate abnormal hemoglobin frequencies ranging from 0.22% to 31% [ 4 , 5 , 9 , 13 , 20 , 23 – 25 ]. Some of these observations are comparable to ours [ 4 , 5 ]; on the other hand, others had different results from ours [ 9 , 13 , 20 , 23 – 25 ].…”

Section: Discussionmentioning

confidence: 99%

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Neonatal Screening for Sickle Cell Disease in Congo

Dokékias

Gokaba

Louokdom³

et al. 2022

Anemia

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Introduction. Sickle cell disease is an autosomal recessive inherited disorder due to the mutation of a gene coding for the globin beta chain. The aim of this study is to update the epidemiological data on hemoglobinoses, in particular sickle cell disease in newborns in Congo. Materials and Methods. This was a descriptive cross-sectional study, conducted from October 1, 2019, to March 31, 2020, throughout the Congolese national territory. It involved all full-term newborns, without distinction of nationality, aged 5 days or less, and whose parents consented to participate in the study. The blood samples, taken at the heel and collected on Whatman blotting paper, were analyzed using the HPLC Variant NBS machine. Results. In 2897 newborns (NN) screened, hemoglobin abnormalities were found in 603 NN (20.81%). The mean age of these newborns was 1 day (extremes 0 and 5 days). The male-to-female ratio was 1.03. Abnormal hemoglobins were mainly Hb S (n = 597 (97.71%)); Hb C (n = 5 (0.82%)); and variants (n = 7 (1.15%)). The national prevalence of major sickle cell (MSC) syndromes and sickle cell trait was 1.35% and 19.43%, respectively. The prevalence ranged from 1.77% to 2.56% for MSS in four departments and from 20.5% to 25.8% for the sickle cell trait in six other departments. Conclusion. Data on homozygous sickle cell disease remain consistent with previous studies. However, further studies should clarify the molecular anomalies of the variants observed in our samples.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Neonatal Screening for Sickle Cell Disease in Congo

Dokékias

Gokaba

Louokdom³

et al. 2022

Anemia

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“…However, in this study, the circumstances of SCD diagnosis were mainly the presentation of symptomatic patients, and neonatal diagnoses were only reported by 1% of the physicians. This confirmed data in the literature demonstrating that neonatal screening is still very exceptional in sub-Saharan Africa, and so far, no African country has maintained neonatal screening for SCD in its national program [ 26 , 27 , 28 ]. Currently, rapid tests for screening for sickle cell disease with good sensitivity and good specificity exist [ 29 ].…”

Section: Discussionsupporting

confidence: 84%

Sickle Cell Disease in the Democratic Republic of Congo: Assessing Physicians’ Knowledge and Practices

2020

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Background: Sickle cell disease is a major public health issue in the Democratic Republic of Congo (DRC), but it is still poorly understood by health professionals. The objective of this study was to assess the knowledge and practices of Congolese physicians treating sickle cell disease (SCD), in order to identify the areas for improvement in clinical care. Methods: This was a descriptive observational study conducted among Congolese physicians using a questionnaire. Participants were evaluated using a pre-established answer grid. Results: A total of 460 physicians participated, including 81 women (18%), with an average age of 35 years (range 25–60 years). Most physicians were general practitioners. Although self-assessment of their level of knowledge on SCD was estimated as average to good, less than half of the participants (n = 460; 46%) reported adequate management of vaso-occlusive crises, and only 1% of them had received specific training on SCD. Most physicians reported difficulties both in terms of diagnostic (65%) and management (79%) options of SCD patients. This study also showed that 85% of these physicians did not have access to the diagnostic tools for SCD. Conclusions: Insufficient knowledge on SCD and poor diagnostic and treatment options might contribute to increased morbidity and mortality of patients living in the DRC. Interventions aiming to improve physicians’ knowledge, patient follow-up, and treatment access are needed. Specific training alongside existing programs (HIV, malaria), early diagnosis of the disease, and the creation of patient advocacy groups should be implemented to improve SCD patient care.

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“…In 2018 had observed a prevalence of 1.3% in Bamako slightly higher compared to our result. [8]. In Cameroon in 2019, the prevalence of pregnancy for sickle cell disease was 0.1%.…”

Section: Epidemiological Datamentioning

confidence: 99%

Outcome of Pregnancies Among Sickle Cell Patients Admitted to Cotonou University Hospitals (Benin) from 2008 to 2018

Patrice¹,

Tognifode²,

Azonbakin³

et al. 2020

JGO

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Objective: Study the fetal-maternal and neonantal prognosis of sickle cell pregnancies managed in Cotonou's hospitals (R. Benin). Material and methods: This is a descriptive study on retrospective data from January 2008 to December 2018. The maternities of the Lagoon Mother and Child Hospital and University (CHU-MEL) center and of the CNHU/HKM gynecology and obstetrics university clinic had served as a framework. Complete patients records were analyzed. Included were pregnant women or delivered at 28 weeks of amenorrhea (AW) or beyond, sickle cell disease SS or SC confirmed by hemoglobin electrophoresis. Sociodemographic, clinical, therapeutic, and fetal-maternal and neonatal prognosis were analyzed. EPI DATA 3.1 and SPSS 2.0 software were used to analyze our data. The difference is significant for a p-value ≤ 5%. Ethical and professional standards and rules were respected. Results: The delivery of a patient suffering from sickle cell disease represented 0.82% of births. The SS phenotype was observed in 27.3% (n=105) versus 72.7% (n=279) of SC (p=0.000). A history of obstetric complications was noted in 56.8% (n=218). The course of the current pregnancy was marked by obstetric complications in 97.4% and the most important were: the threat of premature delivery (28%) and the vaso-occlusive crisis (19.5%). The caesarean was performed in 92% of sickle cell patients. Premature delivery was observed in 60% with 6.3% very premature (28-33AW). It was registered 91% (n=352) live births, 48% (n=169) hypotrophs, 60% premature, 1.1% (n=4) intrapartum deaths and 8% (n=4) intrapartum deaths and 8% (n=31) deaths in utero. Perinatal mortality represented 9%. The after-effects of childbirth were complicated in 12% (n=46). The puerperal infections (32.6%), hypertension (28.2%) and its complications and severe anemia (19.2%) were the most common complications. Five (5) maternal deaths were deplored, ie a mortality rate of 1420 maternal deaths per 100,000 live births. Conclusion: In Benin, pregnancy and delivery of sickle cell disease are at high risk of fetal, maternal and neonatal mortality. Caesarean section was almost routine in this group. The practice of transfusion exchange or bleeding may improve prognosis.

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Dépistage néonatal ciblé de la drépanocytose : limites du test de falciformation (test d’Emmel) dans le bilan prénatal en zone ouest africaine

Cited by 14 publications

References 15 publications

Neonatal Screening for Sickle Cell Disease in Congo

Neonatal Screening for Sickle Cell Disease in Congo

Sickle Cell Disease in the Democratic Republic of Congo: Assessing Physicians’ Knowledge and Practices

Outcome of Pregnancies Among Sickle Cell Patients Admitted to Cotonou University Hospitals (Benin) from 2008 to 2018

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