2022
DOI: 10.3389/fimmu.2022.843342
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Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection

Abstract: Uncontrolled severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 infection is closely related to disorders of the innate immune and delayed adaptive immune systems. Dendritic cells (DCs) “bridge” innate immunity and adaptive immunity. DCs have important roles in defending against SARS-CoV-2 infection. In this review, we summarize the latest research concerning the role of DCs in SARS-CoV-2 infection. We focus on the complex interplay between DCs and SARS-CoV-2: pyroptosis-induced activation; activation … Show more

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Cited by 34 publications
(34 citation statements)
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References 149 publications
(230 reference statements)
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“…In these cells, the Spike protein can also induce integrin α5β1-dependent signaling leading to nuclear translocation of NF-κB, with consequent expression of the leukocyte adhesion molecules VCAM-1 and ICAM-1; coagulation factors; and the release of TNFα, IL-1β, and IL-6 pro-inflammatory cytokines [ 42 ]. Similar activation mechanisms were described in both macrophages and dendritic cells [ 43 , 44 , 45 ].…”
Section: Intracellular Signaling Induced By the Spike-protein-induced...supporting
confidence: 63%
“…In these cells, the Spike protein can also induce integrin α5β1-dependent signaling leading to nuclear translocation of NF-κB, with consequent expression of the leukocyte adhesion molecules VCAM-1 and ICAM-1; coagulation factors; and the release of TNFα, IL-1β, and IL-6 pro-inflammatory cytokines [ 42 ]. Similar activation mechanisms were described in both macrophages and dendritic cells [ 43 , 44 , 45 ].…”
Section: Intracellular Signaling Induced By the Spike-protein-induced...supporting
confidence: 63%
“…A decrease in the total pool of circulating DCs is characteristic not only of the acute period of SARS-CoV-2 but is also found in recovered patients [ 21 , 22 ]. Peripheral blood DCs are a heterogeneous population of leukocytes which is traditionally subdivided into myeloid or conventional CD123–CD11c+ dendritic cells (cDCs) and CD123+CD11c− plasmacytoid dendritic cells (pDCs) [ 23 , 24 ].…”
Section: Antigen-presenting Cells In Covid-19mentioning
confidence: 99%
“…Moreover, the antigen processing and presentation to T cells allows the induction of the adaptive specific T‐cell response. During severe SARS‐CoV‐2 infection, the percentage of DC subsets decrease [ 27 ], and their functionality, in terms of IFN‐α production and antigen presentation potential, is impaired [ 27 , 28 , 29 ].…”
Section: The Innate Immunity Plays a Key Role In Early Protectionmentioning
confidence: 99%