“…However, such a strategy cannot reduce nitrogen leaching resulting from traditional fertilization techniques [ 35 ]. Moreover, its high enclosure of HMs has been reported to induce depletion of basic soil components, i.e., soil moisture, organic matter, and available phosphorus contents, along with reduced saffron growth [ 36 ]. Although a transition from chemical fertilization to organic farming was proposed [ 37 ], the use of effluents highly rich in organic matter, HMs, BOD 5 , and COD contents for saffron irrigation is a matter of deep discussion and the unraveling of its long-term effect on soil, plant, and human health is still unclear.…”