Depletion of praziquantel from gilthead sea bream (Sparus aurata) muscle plus skin

Abstract

The depletion pattern of praziquantel (PZQ) from gilthead sea bream (Sparus aurata) muscle plus skin was determined in this study. Fish averaging 100.2 ± 17.7 g and kept at 25oC received a PZQ-dosing of 150 mg/kg fish for 3 days. Muscle plus skin of each of ten fish were collected on days 1, 2, 3, 4, and 6 days post-treatment. Depletion of PZQ from the edible gilthead sea bream tissues was rapid, as its concentrations declined to 0.04 μg/g as early as 24 h post-treatment, while was undetectable at 72 h. This information confirms the fact that PZQ is depleted fast from farmed animals including fish such as the gilthead sea bream and its levels in edible tissues failed below the detection limit in approximately 75 dd.

Pharmacokinetics of praziquantel and its metabolites in grass carp (Ctenopharyngodon idella) following the oral administration of a single bolus

“…In our study, the plasma concentrations of PZQ in the grass carp administered a single dose of PZQ at a concentration of 50 mg/kg were found similar to the results obtained in the study of Kogiannou et al (2023) who evaluated single oral PZQ exposition doses (75 and 150 mg/kg) in gilthead seabream (Sparus aurata) which resulted in a plasma concentration of PZQ ranging approximately between 1.0 and 2.3 mg/l within 24 h to 96 h after exposure. They also published similar conclusions for PZQ in the gill ranging approximately between 0.1 mg/kg to 2.0 mg/kg.…”

“…2022 ), some studies have described the pharmacokinetics of the drugs tested ( Soukupova-Markova et al. 2015 ; Kogiannou and Rigos 2021 ). However, there is a relative lack of literature resources on the pharmacokinetics of the metabolic products of the parent compounds, especially in regards PZQ.…”

“…Depletion studies have been provided for the evaluation of the degradation rate of PZQ in fish, for example, with rainbow trout ( Oncorhynchus mykiss ) following the oral administration of a single dose of 50 mg/kg body weight ( Soukupova-Markova et al. 2015 ), gilthead sea bream ( Sparus aurata ) after 3-days receiving 150 mg/kg ( Kogiannou and Rigos 2021 ), cultured rockfish ( Sebastes schlegelii ) after the oral administration of 200 and 400 mg/kg body weight ( Kim et al. 2003 ), or rice field eels ( Monopterus albus ) fed 10 mg/kg body weight ( Xu et al.…”