Depletion of substance P, a mechanism for inhibition of mouse scratching behavior by tacrolimus

Inagaki, Nobuya; Shiraishi, Noriko; Igeta, Katsuhiro; Nagao, Masafumi; Kim, John Fan; Chikumoto, Takao; Itoh, Tomokazu; Katoh, Hideo; Tanaka, Hiroyuki; Nagai, Hiroichi

doi:10.1016/j.ejphar.2009.09.043

Cited by 26 publications

(25 citation statements)

References 30 publications

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“…One of the most important aims in the treatment of atopic dermatitis is the regulation of itching and scratching. There are several studies that compared the effect of tacrolimus with that of dexamethasone, a mild corticosteroid, in experimental models of atopic dermatitis (22,29,30). In an interesting experimental model, dermatitis was induced by repeated application of a hapten, DNFB, to the mouse ear, resulting in frequent scratching behaviors and ear swelling (22,25).…”

Section: Discussionmentioning

confidence: 99%

“…There are several studies that compared the effect of tacrolimus with that of dexamethasone, a mild corticosteroid, in experimental models of atopic dermatitis (22,29,30). In an interesting experimental model, dermatitis was induced by repeated application of a hapten, DNFB, to the mouse ear, resulting in frequent scratching behaviors and ear swelling (22,25). Topically applied tacrolimus exhibits potent inhibitory actions with regard to scratching behavior in spite of its relatively weak anti-inflammatory activity, whereas dexamethasone exhibits potent anti-inflammatory activity without affecting the scratching behavior.…”

Section: Discussionmentioning

confidence: 99%

“…Dermatitis and scratching behavior were induced by repeated treatment of each surface of both ears with DNFB solution in BALB/c mice, as previously described (22,25). Briefly, 2 weeks after sensitization with DNP-Ascaris and alum (day 15), a total volume of 100 μL of DNFB dissolved in acetone at a concentration of 0.15% was topically applied every 48 h to both sides of each ear lobe, 5 times in total (days 15, 17, 19, 21, and 23).…”

Section: Experimental Protocolmentioning

confidence: 99%

“…In this study, we examined the effects of RG on histamine-induced vascular permeability in rats and on experimental dermatitis in mice caused by repeated application of 2,4-dinitrofluorobenzene (DNFB) solution, which induced eczematous changes of the ear and caused a persistent increase in scratching behavior (22). Tacrolimus and RG significantly reduced DNFB-induced increase in scratching behavior and ear swelling.…”

Section: Introductionmentioning

confidence: 99%

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Red Ginseng Inhibits Scratching Behavior Associated With Atopic Dermatitis in Experimental Animal Models

Samukawa¹,

Izumi²,

Shiota³

et al. 2012

J Pharmacol Sci

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Abstract. Pruritus is a severe symptom that is difficult to treat in atopic dermatitis patients. Red ginseng (RG), a natural medicine, has various biological activities such as anti-inflammatory effects. In this study, we examined the efficacy of RG extract (RGE) and its mechanism on experimental atopic dermatitis in mice. The effects of RGE on vascular permeability and itching were first evaluated. Histamine-induced permeability and itching were significantly inhibited by embrocation with RGE as well as diphenhydramine, an antihistamine drug. Next, we assessed the therapeutic effect of topical RGE in a mouse model of atopic dermatitis. Dermatitis was induced by repeated application of 2,4-dinitrofluorobenzene (DNFB) acetone solution to the mouse ear. The effects of tacrolimus (a calcineurin blocker), dexamethasone (a corticosteroid), and RGE on dermatitis and associated scratching behavior were compared. Repeated DNFB application caused frequent scratching behaviors and ear swelling. Topical treatment with tacrolimus, dexamethasone, and RGE for 8 days before the final challenge with DNFB significantly inhibited ear swelling. Tacrolimus and RGE significantly inhibited scratching behavior, whereas dexamethasone failed to do so. DNFB-induced nerve growth factor expression and nerve fiber extension were significantly attenuated by tacrolimus and RGE, but not by dexamethasone. RGE may have the potential for treatment of atopic dermatitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Experimental Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Red Ginseng Inhibits Scratching Behavior Associated With Atopic Dermatitis in Experimental Animal Models

Samukawa¹,

Izumi²,

Shiota³

et al. 2012

J Pharmacol Sci

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“…Psychological stress such as anxiety is thought to be associated with the induction of pruritus through mediating neuropeptides such as neuropeptide Y and substance P in AD [52,53].…”

Section: Citation: Park Yd Yang Jm (2014) Omics Integration Studies mentioning

confidence: 99%

OMICS Integration Studies for New Insights on Atopic Dermatitis

Park¹

2014

CDT

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The number of Atopic Dermatitis (AD) patients has increased with modernization and industrialization, and AD patients and their family members experience severe quality of life issues. It is generally recognized that a combination of environmental factors such as allergens and bacterial infections, as well as genetic factors, are the principal inducers of the multiple immunologic and inflammatory responses seen in AD patients. In the present review article, we focused on the following primary issues from the broad category of AD disease that have been reported in research articles, including those by the authors' own research groups: i) AD types: characteristics of extrinsic and intrinsic types; ii) current treatments of AD and clinical applications; iii) new insights from OMICS integration studies for detecting hub genes; iv) summary of AD pathogenesis and associated factors; and v) further speculation for AD studies. The topics in this review that we focused on are expected to contribute to the understanding of AD disease-related factors. Since the mechanism of AD disease has been shown to be complex, our results may provide new clues to aid understanding of AD from the aspect of laboratorial OMICS applications.

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Intravesical immune suppression by liposomal tacrolimus in cyclophosphamide‐induced inflammatory cystitis

Chuang

Tyagi

Huang

et al. 2010

Neurourology and Urodynamics

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Depletion of substance P, a mechanism for inhibition of mouse scratching behavior by tacrolimus

Cited by 26 publications

References 30 publications

Red Ginseng Inhibits Scratching Behavior Associated With Atopic Dermatitis in Experimental Animal Models

Red Ginseng Inhibits Scratching Behavior Associated With Atopic Dermatitis in Experimental Animal Models

OMICS Integration Studies for New Insights on Atopic Dermatitis

Intravesical immune suppression by liposomal tacrolimus in cyclophosphamide‐induced inflammatory cystitis

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