Depletion Study of Oxolinic Acid in Freshwater Softshell Turtle (Pelodiscus sinensis) with Multiple-Dose Oral Administration

Abstract

All drugs used in aquaculture must be approved by the government agency responsible for veterinary medicine; prudent use of antibiotics under veterinary supervision is critical in ensuring safety of aquaculture products. The international production of farmed turtle, considered a cultured aquatic species, has been growing continuously but control of bacteria proliferation in turtle farms requires frequent use of antimicrobials. In the present investigation, the residue depletion and withdrawal period of quinolone antibacterial oxolinic acid (OXO) was evaluated in Chinese softshell turtle Pelodiscus sinensis, after repeated (once daily for 5 days) oral doses of medicated feed containing OXO, at the dose of 30 and 60 mg/kg body weight (bw). Muscle and liver tissues were collected at 1